Hypoglycemic potential of Aloe vera in diabetes mellitus induced by diabetogenic substances and high fat diet: A systematic meta-analysis review

Abstract

Diabetes mellitus is a chronic disease that has always been the primary health concern worldwide. A few herbal plants showed anti-diabetic potential, Aloe is among these few species, and the pharmacological effects may vary for Aloe leaf preparations. We carried out a systematic and meta-analysis review to evaluate the hypoglycemics property of Aloe vera in Diabetes Mellitus Condition to develop its therapeutic benefit information and knowledge. The search used the following medical subject headings (MeSH): Aloe, aloe spp, diabetes mellitus, and hyperglycemia. This was followed by keyword search using Aloe vera or aloe gel or aloe polysaccharide or acemannan or aloe phytosterols or aloe elements. The historical search of relevant articles and personal contact with experts in the area were also undertaken. Twelve articles discuss the hypoglycemia effect of Aloe vera or Barbaloin or acemannan based in vivo study. Ten articles discuss the hypoglycemia effect of Aloe vera extract, and two articles discuss the hypoglycemia effect of the component of Aloe vera. In contrast, one article discusses the beneficial effect of polysaccharide equivalent Aloe vera gel on blood glucose levels in vivo and Yiman using Chromones based on Aloe vera. Several articles have been reviewed and concluded about the antidiabetic effect of Aloe vera on animal studies with the favorable properties and ability of this material, such as the antioxidant and anti-inflammatory ability.