Hypoglycemic, vasorelaxant and hepatoprotective effects of Cochlospermum vitifolium (Willd.) Sprengel: A potential agent for the treatment of metabolic syndrome

Sánchez-Salgado, Juan Carlos; Ortíz-Andrade, Rolffy; Aguirre‐Crespo, Francisco; Vergara-Galicia, Jorge; León‐Rivera, Ismael; Montes, Sergio; Villalobos‐Molina, Rafael; Estrada‐Soto, Samuel

doi:10.1016/j.jep.2006.08.008

Cited by 38 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding is in agreement with the description of Biavatti et al (2004), which reported a 15 % reduction in the plasma glucose level of obese rats (induced with a hypercaloric diet) treated with C. xanthocarpa. In other pharmacological investigations involving hypoglycemic plants, a 12 to 20 % reduction in blood glucose level was considered significant (Sánchez- Salgado et al, 2007 andCavalli et al, 2007). In the control rats treated with C. xanthocarpa, blood glucose levels displayed no significant variation.…”

Section: Biochemical Resultsmentioning

confidence: 99%

“…Despite the great efforts made to better understand and manage this disease, serious problems such as retinopathy, nephropathy and lower extremity amputation continue to affect patients, while diabetes-related mortality is rising unabated (Tiwari, Rao, 2002). Insulin resistance can also lead to Metabolic Syndrome (MS), a complex metabolic disease characterized by obesity, hypertension, dyslipidemia and DM2 (Sanchéz- Salgado et al, 2007). The current rise in DM2 and MS is believed to be a result of an increase in the sedentary life styles combined with ready access to energy-rich food sources in genetically susceptible individuals (Savage et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed. O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/ kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.Unitermos: Campomanesia xanthocarpa/farmacognosia. Diabete Melito/estudo experimental. Planta hipoglicemiante. Carboidratos/metabolismo. Lipídeos/metabolismo.

show abstract

Section: Biochemical Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…For example, the Traditional Chinese Medicine, particularly the Compendium of Materia Medica (Bencao Gangmu, Li Shizhen, Ming Dynasty 1518-1593) detailing 1900 herbal species, the Ayurvedic medicines, United States Pharmacopeia and the National Formulary, Egyptian medicines are good sources of information. In Mexico, medicinal plants are actually selected based on the taste and smell [8]. On the other hand, if one wants to look for plants that are potentially useful for treating metabolic syndrome, there may not be as many.…”

Section: Selection Strategies For the Test Pipeline: Why To Test Thismentioning

confidence: 99%

“…An allergy preventative plant extract was fractionated in column chromatography resulting in the purification and identification of eight flavonoidal compounds, all of which contributed to the observed allergy preventative activities [42]. Sánchez-Salgado et al [8] investigated the effect of Cochlospermum vitifolium (Willd.) Sprengel on metabolic syndrome.…”

Section: Identification Of Active Molecules In Botanical Samples -Is mentioning

confidence: 99%

“…Cochlospermum vitifolium (Willd.) Sprengel, a Mexican medicinal plant that is used in the folk medicine for the treatment of hypertension, diabetes, hepatitis, and related diseases was tested in bioassays related to metabolic syndrome and is confirmed with its hypoglycemic property [8]. Recently, the effects of dietary patterns, specific food consumptions, and fruit and vegetable consumptions on metabolic syndrome have been investigated in human clinical trials [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of Botanical Samples for Biomedical Research

Liu

2008

EMIDDT

View full text Add to dashboard Cite

Plants are chemical storehouses, a fact which has driven countless multidisciplinary quests for bioactive compounds. As the very first step of botanical research, the whole desire is to find "hit" plants with specific bioactivities. It is logical to use some strategies that can maximize the chances of finding these "hits" with limited time and resources. In addition to selecting the right plants for screening, how the plant extracts are prepared can also influence the bioactivity screening outcomes. An extract from the same plant material can be quite different in chemical composition having different preparations. Because of the complex mixture nature of plant extracts, it is possible artifact activities may be observed. Thus confirmatory activity tests are often necessary to warrant the next laborious isolation step. A bioassay directed isolation approach may be the most efficient in identifying the bioactive compounds because of the narrowed focus at each isolation step, but a phytochemistry isolation approach is appropriate to characterize a purified bioactive extract. In fact, these two approaches can be taken intermittently whenever efficiency can be improved. Finally, use of the identified active compounds is now broader. In addition to determining a lead compound to continue a drug development path, there is an increasing interest in support for the use of botanical extracts as botanical drugs. Instead of dropping the extract after extracting the lead compound, the natural analogues representing the purified extract now have a chance to become leading compounds in the pursuit of novel therapies for metabolic syndrome and other diseases.

show abstract

Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects

2015

View full text Add to dashboard Cite

The liver is one of the most important organs of human body, being involved in several vital functions and regulation of physiological processes. Given its pivotal role in the excretion of waste metabolites and drugs detoxification, the liver is often subjected to oxidative stress that leads to lipid peroxidation and severe cellular damage. The conventional treatments of liver diseases such as cirrhosis, fatty liver and chronic hepatitis are frequently inadequate due to side effects caused by hepatotoxic chemical drugs. To overcome this problematic paradox, medicinal plants, owing to their natural richness in phenolic compounds, have been intensively exploited concerning their extracts and fraction composition in order to find bioactive compounds that could be isolated and applied in the treatment of liver ailments. The present review aimed to collect the main results of recent studies carried out in this field and systematize the information for a better understanding of the hepatoprotective capacity of medicinal plants in in vitro and in vivo systems. Generally, the assessed plant extracts revealed good hepatoprotective properties, justifying the fractionation and further isolation of phenolic compounds from different parts of the plant. Twenty-five phenolic compounds, including flavonoids, lignan compounds, phenolic acids and other phenolic compounds, have been isolated and identified, and proved to be effective in the prevention and/or treatment of chemically induced liver damage. In this perspective, the use of medicinal plant extracts, fractions and phenolic compounds seems to be a promising strategy to avoid side effects caused by hepatotoxic chemicals.

show abstract

Hypoglycemic, vasorelaxant and hepatoprotective effects of Cochlospermum vitifolium (Willd.) Sprengel: A potential agent for the treatment of metabolic syndrome

Cited by 38 publications

References 28 publications

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Preparation of Botanical Samples for Biomedical Research

Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects

Contact Info

Product

Resources

About