Hypogonadism in thalassemia major patients

Srisukh, Sasima; Ongphiphadhanakul, Boonsong; Bunnag, Pongamorn

doi:10.1016/j.jcte.2016.08.001

Cited by 33 publications

(41 citation statements)

References 38 publications

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“…Comparable to other studies hypogonadism was the most common endocrinopathy in our patients (18)(19)(20)(21). Out of 42 patients (28 female and 14 males) who were evaluated for pubertal development, the overall prevalence of hypogonadism was 78.6%, including 71% of girls and 92% of boys.…”

Section: Discussionsupporting

confidence: 48%

The prevalence of endocrinopathies among patients with thalassemia major in the district of Batticaloa, Sri Lanka

Karuppiah

Arawa

Sivaganam

et al. 2017

Sri Lanka J. Diabetes Endocrinol. Metab.

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Section: Discussionsupporting

confidence: 48%

The prevalence of endocrinopathies among patients with thalassemia major in the district of Batticaloa, Sri Lanka

Karuppiah

Arawa

Sivaganam

et al. 2017

Sri Lanka J. Diabetes Endocrinol. Metab.

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“…In the classic knowledge, iron accumulated in the pituitary gland of thalassemia patients results a cytotoxic effect. These cytotoxic effects result to hyporesponsiveness of pituitary gland to GnRH and lead to hypergonadotrophic hypogonadism [34], which can appear as low estradiol or testosterone with LH and low FSH [8]. Iron overload is also exist in reproductive glands which lead to undifferentiate the sperm tubes, decrease number of Leydig cells, and interstitial fibrosis in varying degrees [35,36].…”

Section: Discussionmentioning

confidence: 99%

“…Iron overload is also exist in reproductive glands which lead to undifferentiate the sperm tubes, decrease number of Leydig cells, and interstitial fibrosis in varying degrees [35,36]. It is clear that during childhood, the levels of testosterone, LH, and FSH remain very low until the onset of puberty [8]. These evidences can explain the high level of LH, FSH, and testosterone in TM patients aged ≥18 years compared to TM patients aged ˂18 years.…”

Section: Discussionmentioning

confidence: 99%

“…Glandular insufficiency does not respond to late chelation treatment of the disease [37], but prepuberty chelation therapy has helped patients get natural sexual maturity in some studies [8]. In contrast, another study reported that there was no difference in the frequency of pluripotent maturity when treatment began with iron ingestion at the age of 10 or earlier [18].…”

Section: Discussionmentioning

confidence: 99%

“…Iron overload caused many complications. One of these complications is hypogonadism in thalassemia patients [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Age, and Spleen and Treatment Status on Male Reproductive Hormones and Some Physiological Parameter Levels in Patients With Beta-Thalassemia Major

Jouda¹,

Ghazzay²,

AL-Mosawy³

2019

Asian J Pharm Clin Res

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Objective: This research was conducted to study the relationship between spleen status and chelation treatment status with the male reproductive hormones and some physiological parameter levels. Methods: A total of 35 males with thalassemia major (TM) patients are recruited. Patients are grouped according to (1) their age into two groups; ˂18 years and ≥18 years, (2) their spleen status into two groups; splenectomize and non-splenectomize, and (3) their chelation treatment status into two groups; regulation and irregulation. Body mass index (BMI) was calculated and blood was collected from all patients just before blood transfusion session. Hb, ABO blood groups, ferritin, and hormone (luteinizing hormone [LH], follicle-stimulating hormone [FSH], testosterone, prolactin, and cortisone) levels were determined. Results: The highest frequency of thalassemia was in Group O and the lowest was in AB. BMI was higher in TM patients aged ≥18 years, TM patients with splenectomize, and TM patient who take the treatment irregularly. TM patients aged ≥18 years have high level of LH, FSH, and testosterone. TM patients without splenectomize have higher FSH, prolactin, and testosterone. TM patients take the treatment regularly have significantly higher testosterone levels and non-significantly lower FSH level. Conclusion: The levels of cortisol and prolactin hormones are not disturbed in TM patients and not associated with the rate of transfusion, but the level of Hb and ferritin leads to underweight in BMI and may lead to endocrine dysfunction, especially sexual hormones (FSH, LH, and testosterone). These BMI and sex hormones are related to age, spleen, and treatment status.

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Experiences, Knowledge Gaps and Information Needs of Women in Australia with Transfusion Dependent Thalassaemia in Regard to Fertility and Pregnancy

Matthiesson,

Berdoukas,

Briganti

2023

Matern Child Health J

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Objectives Transfusion dependent β-thalassaemia can have significant effects on fertility and is also associated with significant risks in pregnancy. However, little is known about the perspectives of women living with the condition with regards to reproductive issues. The aim of this study was to assess the experience, knowledge and information needs of Australian women living with transfusion dependent β-thalassaemia in relation to fertility and pregnancy. Methods A cross sectional study using an online anonymous survey, self-administered through REDCap, addressing key issues related to the experience, knowledge and information needs of women with transfusion dependent β-thalassaemia. Descriptive and inferential analysis was conducted using STATA. Results Sixty participants were included in the analysis. Two-thirds of sexually active, pre-menopausal women were using contraception. Just under half of the participants who were sexually active had children and half had required some form of assisted reproductive technology to achieve a pregnancy. Less than half identified the importance of contraception as part of ensuring optimised pre-pregnancy care, and less than half had accessed pre-pregnancy care. Although there was good understanding of the increased risk of infertility and pregnancy complications, the specific risks and causes of these risks were poorly understood. Around half of the participants indicated they wanted more information on these medical issues. Conclusions for practice Our study demonstrated significant concerns and knowledge gaps in Australian women with transfusion dependent β-thalassaemia with regards to disease-specific issues related to fertility and pregnancy, and a desire for related patient information.

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Hypogonadism in thalassemia major patients

Cited by 33 publications

References 38 publications

The prevalence of endocrinopathies among patients with thalassemia major in the district of Batticaloa, Sri Lanka

The prevalence of endocrinopathies among patients with thalassemia major in the district of Batticaloa, Sri Lanka

Effect of Age, and Spleen and Treatment Status on Male Reproductive Hormones and Some Physiological Parameter Levels in Patients With Beta-Thalassemia Major

Experiences, Knowledge Gaps and Information Needs of Women in Australia with Transfusion Dependent Thalassaemia in Regard to Fertility and Pregnancy

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