Hypogonadotropic Hypogonadism with Cushing?s Disease-A Case Report

Abstract

A 27 year old woman presented with secondary amenorrhoea. She was obese and had marked pigmentation on face, abdominal striae and severe hypertension. Endocrinal work up revealed low estradiol with low gonadotrophin levels suggesting hypogonadotropic hypogonadism. A magnetic resonance imaging revealed a macroadenoma in the anterior pituitary. A raised cortisol and a raised adenocorticotropic hormone level confirmed the diagnosis of Cushing's disease. The pituitary macroadenoma was resected with Leksell Gamma knife radiosurgery. The response on her reproductive function was immediate, as she had spontaneous menstruation just three weeks after surgery. She also became normotensive and is being kept on follow up.