A 27 year old woman presented with secondary amenorrhoea. She was obese and had marked pigmentation on face, abdominal striae and severe hypertension. Endocrinal work up revealed low estradiol with low gonadotrophin levels suggesting hypogonadotropic hypogonadism. A magnetic resonance imaging revealed a macroadenoma in the anterior pituitary. A raised cortisol and a raised adenocorticotropic hormone level confirmed the diagnosis of Cushing's disease. The pituitary macroadenoma was resected with Leksell Gamma knife radiosurgery. The response on her reproductive function was immediate, as she had spontaneous menstruation just three weeks after surgery. She also became normotensive and is being kept on follow up.
Purpose The prevalence of male subfertility is increasing among couples seeking fecundity in recent years. A prospective study was carried out in a gynaecological outpatient , to determine the benefit of a low cost algorithm for diagnosis of adult males with suboptimal semen parameters. Materials and Methods Twenty nine males, who had a sperm concentration less than 15 million/ml were considered in the study. The cost of diagnosis was kept low ; not exceeding 150 US dollars. A similar algorithm of investigation was followed for all patients and medical treatment provided as per treatment guidelines .Results A confirmed etiology could be determined in 9 patients , while a probable diagnosis was suggested in 17 males. Endocrino-metabolic causes were the most important etiological factors in our Indian population . Lifestyle diseases like obesity , insulin resistance were prominently found in the suspected acquired hypogonadotropic hypogonadism group..Medical treatment was provided to 24 males, and 64% showed good improvement in seminal count , after 3 months of therapy. Only selected patients were referred to higher teritiary centres, for specific interventions like sperm retrieval techniques , intracytoplasmic sperm injection of the female partner. Conclusion This study proves that male subfertility can be managed in a low resource semiurban centre, with the help of a simple algorithm with ease and proficiency,hence reducing economic burden on these couples. Also, this analysis has helped us to ascertain the relative propensity of etiological factors among adult males with infertility ,in North India in the present time.
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