Hypolipidaemic Activity in Rats of Bergenin, the Major Constituent of Flueggea microcarpa

Abstract

Oral administration of bergenin, isolated from the leaves of Flueggea microcwpu, to hyperlipidaemic rats for 14 days significantly decreased serum total lipid without much change in serum cholesterol and triglycerides. However, after 21 days of administration, the serum cholesterol, triglycerides, low-density lipoprotein (LDL)-and very low-density lipoprotein (VLDL)-cholesterol levels were significantly reduced while the serum highdensity lipoprotein (HDL)-cholesterol level was elevated. Bergenin-treated animals also showed a significant decrease in atherogenic index.

The genus Ardisia: a novel source of health-promoting compounds and phytopharmaceuticals

“…Bergenin is an isocoumarin found in various plant species and exhibits a wide range of biological activities including hepatoprotective (Lim et al, 2000), antifungal (Prithivirai et al, 1997), anti-HIV (Piacente et al, 1996), antiarrhythmic (Pu et al, 2002) and hypolipidemic (Jahromi et al, 1992). Along with bergenin (Fig.…”

Diversity, pharmacology and synthesis of bergenin and its derivatives: Potential materials for therapeutic usages

“…Oral administration of bergenin (1) to hyperlipidemic rats significantly decreased serum total lipid but not much change in serum cholesterol and triglycerides for 14 days [82]. However after 21 days of feeding, serum cholesterol, triglycerides, low-density lipoprotein-cholesterol levels were significantly reduced, while the serum high-density-cholesterol level was elevated.…”

Anti-inflammatory and non ulcerogenic activities of acetylbergenin

“…Bergenin (1) is a C-glucoside of 4-O-methyl gallic acid that has been isolated as the major component from the cortex of E. uchi and is used for treating gastrointestinal diseases such as gastritis, gastric ulcer, diarrhea, and constipation (Okada et al, 1973;Abe et al, 1980). In addition, studies report that bergenin reveals anti-inflammatory (Swarnalakshmi et al, 1984;Nunomura et al, 2009), antiarthritic (Nazir et al, 2007) and hypolipidemic effects (Jahromi et al, 1992). In our laboratory, bergenin (1) was isolated as the principal component from the aqueous extract of the E. uchi cortex and acetylbergenin (2) was obtained by acetylation of bergenin in order to increase its lipophilic and physiological activities.…”