Hypolipidaemic effects of papaya (Carica papayaL.) juice on rats fed on a high fat and fructose diet

Abstract

Papaya (Carica papaya L.) is a highly nutritious and less-caloric fruit, commonly consumed for its minerals and vitamins and hence may help in controlling obesity and abdominal discomforts. The present study investigated the hypolipidaemic effects of papaya juice extract on male Albino Wistar rats (7 weeks old; 185 ± 17 g) fed on a high fat and fructose diet (HFFD) for 6 weeks. The rats were divided into groups I–IV of five rats each and fed on either a HFFD (i.e. the Control), HFFD + 200 mg papaya, HFFD + 350 mg papaya or a HFFD + 500 mg papaya. On day 34, after an overnight fast, blood samples were obtained by cardiac puncture under 99⋅8 % Chloroform anaesthesia for the determination of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density cholesterol (HDL-c). The atherogenic (AI) and coronary risk (CRI) indices were also calculated. Statistical analysis was performed using ANOVA where means were separated using Tukey's HSD test. Resulted showed that all rats given papaya juice had an increasing, non-significant HDL-c and reduced LDL-c levels while rats fed on HFFD had the highest TC (53⋅2 mg/dl) and TG (37⋅6 mg/dl) levels. Papaya juice statistically reduced the AI and CRI of the rats. In conclusion, consumption of HFFD + 500 mg was the most effective in the reduction of rats’ blood lipids and fats, due to its anti-obesity and hypolipidaemic properties, thus can be used in the management of dyspilidaemic disorders.

Supplementation of papaya leaf juice has beneficial effects on glucose homeostasis in high fat/high sugar-induced obese and prediabetic adult mice

“…2 G). The anti-obesity and hypolipidemic properties of PL juice supplementation in our study are consistent with those observed in other studies on animal models [ 30 ]. Papaya contains many phytochemicals that act as antioxidants and anti-inflammatory agents, including phenolic compounds, benzyl isothiocyanate, and tocopherol [ 31 ].…”

“…IR and GLUT4 muscle expression was elevated by ethanolic PL extracts in diabetic mice, as demonstrated by Roy et al [ 37 ]. This effect may be due to papaya's phenols and flavonoids [ 30 ]. Phytochemicals such as gallotannins, 3-taraxerol, Astragalus polysaccharide, Berberine, and vanillic acid contribute to insulin signaling by increasing GLUT4 translocation, adiponectin secretion, PKB-Ser473 phosphorylation, decreased activity of glucokinase (GK), increased activity of glucose-6-phosphatase (G6Pase), and beta-cell stimulation [ 38 ].…”

Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm

“…The active compound contained in A. catechu will inhibit the gamma amino benzoic acid reaction, which can cause paralysis of worms [32], besides that A. catechu has pharmacological therapeutic effects have various benefits, including can be used for the treatment of diseases caused by parasites and also several other diseases [14].…”