Hypolipidemic Activities of a Series of Pyrazoles of Curcumin

Puneeth, Honnalagere Ramesh; Sharada, A.C.

doi:10.9790/3008-1104030408

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…In this line of research, various plant products and their derivatives have been screened for their biological activities including anticancer properties [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. We have reported the chemical constituents and fatty acid profile of chia seed oil (CSO).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

Gazem

Puneeth

Madhu

et al. 2017

Asian J Pharm Clin Res

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Objective: To investigate the anticancer and anti-inflammatory potential of chia seed oil (CSO) and its blends in vitro. Methods:The in vitro cancer cytotoxic properties ability of CSO and its blends was evaluated by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) and trypan blue assays using major cell lines including chronic myelogenous leukemia, HeLa and MCF-7 cells. The anti-inflammatory effect of the CSO and its blends was studied by assessing the anti-lipoxygenase (LOX) activity in vitro.Results: Incubation with CSO alone significantly inhibited the LOX activity. In the combination groups, CSO slightly increased the inhibition among blends of soybean and palmolein oils. In addition, CSO alone and in blends demonstrated potent and differential anticancer activity in MTT and trypan blue assays. Conclusion:Our results pave the way for the conclusion that CSO alone or in combination with the vegetable oils proves to be a healthy synergistic supplement or an adjuvant for the current diet. The supplementation with CSO is suggested for the modern lifestyle to delay or prevent the incidence of degenerative disorders.

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Section: Introductionmentioning

confidence: 99%

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

Gazem

Puneeth

Madhu

et al. 2017

Asian J Pharm Clin Res

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Ex-vivo transdermal delivery of Annona squamosa entrapped in niosomes by electroporation

Abd-Elghany

Mohamad

2020

Journal of Radiation Research and Applied Sciences

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Reactive molecules derived from molecular oxygen and free radicals are commonly known as Reactive Oxygen Species (ROS). These molecules produce oxidative stress in cells leading to many pathological problems like diabetes, cancer, inflammation, neurodegenerative disorders, and aging. Antioxidants can remove free radicals from the human body. Therefore, it is of remarkable interest to increase the bioavailability of antioxidant drugs by increasing transdermal delivery. Nonionic surfactant vesicles or niosomes are drug carriers used to improve the dermal/transdermal bioavailability of drug supplied to the skin. The present work investigates the efficiency of ex-vivo transdermal delivery of the antioxidant plant extract A. squamosa encapsulated into niosomes using 60 exponentially decaying electroporative pulses of field strength 100 V cm −1 and maximum pulse duration 4 ms. Transdermal delivery was enhanced by applying electroporative pulses with the niosomes entrapping A. Squamosa. The suggested method would help in purifying the body from harmful impurities and oxidants by topical drug enhancers that can be applied directly onto the skin.

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Hypolipidemic Activities of a Series of Pyrazoles of Curcumin

Abstract: curcumin, compounds 3a, 3b and 3e and IC 50 was 17.41, 17.11, 14.02 and 18.7

Cited by 2 publications

References 16 publications

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

Ex-vivo transdermal delivery of Annona squamosa entrapped in niosomes by electroporation

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