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Pomegranate (Punica granatum L. formerly in Punicaceae family) considered to be super food worldwide, belongs to the family Lythraceae. It is primarily cultivated in the Middle East, north and tropical Africa, the Indian subcontinent, Asia and Latin America. The medicinal potential of pomegranate is extensively mentioned in the ancient literature and also used in different system of medicines for a variety of ailments. The chemical constituents of pomegranate have increased the research concern of this fruit in the current years. It includes a variety of bioactive compounds such as quercetin, ellagic acid, punicalagin, pedunculagin, tannic acid, anthocyanins, rutin, catechin and polyphenols. These components of pomegranate possess antioxidant, neuroprotective, anti-inflammatory, anti-angiogenic, anticancerous, anti-mutagenic, cytoprotective, cardiovascular protective, anti-diabetic, anti-ulcerogenic, hepatoprotective, antibacterial and antifungal potentials. It can enhance the male fertility and also protect from the UV induced skin damage. Furthermore, it also illustrate the inhibitory effects on vital metabolic enzymes, stimulate cell differentiation and toxicological properties. The pomegranate also impedes with numerous signalling pathways, which include Bax, Bcl-X, Bad, ERK1/2, JNK, PI3K/AKT, mTOR, PI3K, MAPK and P38. The present review will extensively discuss the above properties of pomegranate and its extracts, supporting the rich nutritive and healthy advantages of the fruit belonging to the monogeneric family.

Objective: To investigate the anticancer and anti-inflammatory potential of chia seed oil (CSO) and its blends in vitro. Methods:The in vitro cancer cytotoxic properties ability of CSO and its blends was evaluated by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) and trypan blue assays using major cell lines including chronic myelogenous leukemia, HeLa and MCF-7 cells. The anti-inflammatory effect of the CSO and its blends was studied by assessing the anti-lipoxygenase (LOX) activity in vitro.Results: Incubation with CSO alone significantly inhibited the LOX activity. In the combination groups, CSO slightly increased the inhibition among blends of soybean and palmolein oils. In addition, CSO alone and in blends demonstrated potent and differential anticancer activity in MTT and trypan blue assays. Conclusion:Our results pave the way for the conclusion that CSO alone or in combination with the vegetable oils proves to be a healthy synergistic supplement or an adjuvant for the current diet. The supplementation with CSO is suggested for the modern lifestyle to delay or prevent the incidence of degenerative disorders.

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curcumin, compounds 3a, 3b and 3e and IC 50 was 17.41, 17.11, 14.02 and 18.7