Hypolipidemic activity of Taraxacum mongolicum associated with the activation of AMP-activated protein kinase in human HepG2 cells

Liu, Yan-Jin; Shieh, Po Chuen; Lee, Jang Chang; Chen, Fu An; Lee, Chih Hung; Kuo, Sheng Chu; Ho, Chi Tang; Kuo, Daih Huang; Huang, Li Jiau; Way, Tzong‐Der

doi:10.1039/c4fo00183d

Cited by 10 publications

(5 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2013 ) and hypolipidemic (Liu et al. 2014 ) effects in HepG2 cells. These findings suggest that consumers can improve their health by choosing eggs selectively, not only to increase their intake of UFA, but also to prevent the occurrence of CVDs and CAD.…”

Section: Discussionmentioning

confidence: 99%

Chinese herb ultrafine powder supplementation improves egg nutritional value and quality in laying hens

Gui,

Azad,

Lin

et al. 2024

Veterinary Quarterly

View full text Add to dashboard Cite

This study evaluates the effects of dietary Chinese herb ultrafine powder (CHUP) supplementation in late-phase laying hens on the quality and nutritional values of eggs. A total of 576 Xinyang black-feather laying hens (300-day-old) were randomly allocated into eight groups for a 120-day feeding trial. Each group contained eight replicates with nine hens per replicate. The experimental groups included the control (basal diet) and different levels of CHUP groups (details in ‘Materials and methods’). The results showed that the eggshell strength was increased ( p < 0.05) in the L, LF, L-LF, L-T, and LF-T groups on day 60 of the trial. In addition, the plasma estradiol level in the L-LF, LF-T, and L-LF-T groups and unsaturated fatty acids concentrations in egg yolk of the CHUP groups (except LF-T group) were increased, whereas total cholesterol (T, L-LF, L-T, and L-LF-T groups) in egg yolk and the atherogenicity (T, L-T, and L-LF-T groups) and thrombogenicity (T, L-LF, L-T, and L-LF-T groups) indexes were decreased ( p < 0.05) on day 60 of the trial compared with the control group. Moreover, bitter amino acids in egg albumen were decreased ( p < 0.05) in the L-LF group on day 60 and the L-LF-T group on day 120 of the trial. Collectively, these findings indicate that dietary CHUP supplementation could improve eggshell quality and increase plasma reproductive hormone, fatty acid and amino acid composition, and nutritional values of eggs, especially L-LF and L-LF-T.

show abstract

Section: Discussionmentioning

confidence: 99%

Chinese herb ultrafine powder supplementation improves egg nutritional value and quality in laying hens

Gui,

Azad,

Lin

et al. 2024

Veterinary Quarterly

View full text Add to dashboard Cite

show abstract

“…The TM extracts have been found useful for hypolipidemic effects due to their down-regulated expression of fatty acid synthase and the inhibiting activity of acetyl-coenzyme A carboxylase through the phosphorylation of AMP-activated protein kinase (Liu et al. 2014 ). In vivo and in vitro studies showed that SM extracts, such as tanshinone IIA and salvianolate, induce anti-oxidative and anti-inflammatory effects (Ren et al.…”

Section: Discussionmentioning

confidence: 99%

Dietary Chinese herbal formula supplementation improves yolk fatty acid profile in aged laying hens

Li,

Meng,

Azad

et al. 2024

Veterinary Quarterly

View full text Add to dashboard Cite

Chinese herbal formula (CHF) has the potential to improve the performance of aged laying hens through integrated regulation of various physiological functions. The present study aimed to investigate the effects of dietary CHF supplementation on the yolk fatty acid profile in aged laying hens. A total of 144 healthy 307-day-old Xinyang black-feather laying hens were randomly allocated into two groups: a control group (CON, fed a basal diet) and a CHF group (fed a basal diet supplemented with 1% CHF; contained 0.30% Leonurus japonicus Houtt., 0.20% Salvia miltiorrhiza Bge., 0.25% Ligustrum lucidum Ait., and 0.25% Taraxacum mongolicum Hand.-Mazz. for 120 days). The fatty acid concentrations in egg yolks were analyzed using a targeted metabolomics technology at days 60 and 120 of the trial. The results showed that dietary CHF supplementation increased ( p < .05) the concentrations of several saturated fatty acids (SFA, including myristic acid and stearic acid), monounsaturated fatty acids (MUFA, including petroselinic acid, elaidic acid, trans-11-eicosenoic acid, and cis-11-eicosenoic acid), polyunsaturated fatty acids (PUFA, including linolelaidic acid, linoleic acid, γ-linolenic acid, α-linolenic acid, 11c,14c-eicosadienoic acid, eicosatrienoic acid, homo-γ-linolenic acid, arachidonic acid, and docosapentaenoic acid), and fatty acid indexes (total MUFA, n-3 and n-6 PUFA, PUFA/SFA, hypocholesterolemic/hypercholesterolaemic ratio, health promotion index, and desirable fatty acids) in egg yolks. Collectively, these findings suggest that dietary CHF supplementation could improve the nutritional value of fatty acids in egg yolks of aged laying hens, which would be beneficial for the production of healthier eggs to meet consumer demands.

show abstract

“…In vitro; 0, 50, 100, 200, and 400 mg•mL −1 It possessed the most effective hypolipidemic activity in HepG2 cells. [111] Chlorogenic acids T. antungense…”

Section: Ethanol Extracts T Mongolicummentioning

confidence: 99%

Dandelion (Taraxacum Genus): A Review of Chemical Constituents and Pharmacological Effects

et al. 2023

View full text Add to dashboard Cite

Dandelion (Taraxacum genus) is a perennial herb belonging to the Asteraceae family. As a well-known and extensively studied genus, dandelion comprises numerous species. Some species have been widely used in both complementary and alternative medicine to clear heat, detoxify, activate blood circulation, dispel stasis, and discharge urine. Multiple pharmacological studies have highlighted its therapeutic potential, including anti-bacterial, anti-oxidant, anti-cancer, and anti-rheumatic activities. Furthermore, bioactive compounds associated with these effects include sesquiterpenoids, phenolic compounds, essential oils, saccharides, flavonoids, sphingolipids, triterpenoids, sterols, coumarins, etc. Based on recent studies about the Taraxacum genus, the present review critically evaluates the current state of dandelion utilization and summarizes the significant roles of dandelion and its constituents in different diseases. We also focus on the reported phytology, chemical composition, pharmacology, and toxicity of dandelion, along with the main possible action mechanisms behind their therapeutic activities. Meanwhile, the challenges and future directions of the Taraxacum genus are also prospected in this review, thus highlighting its pharmaceutical research and practical clinical applications.

show abstract

Hypolipidemic activity of Taraxacum mongolicum associated with the activation of AMP-activated protein kinase in human HepG2 cells

Cited by 10 publications

References 51 publications

Chinese herb ultrafine powder supplementation improves egg nutritional value and quality in laying hens

Chinese herb ultrafine powder supplementation improves egg nutritional value and quality in laying hens

Dietary Chinese herbal formula supplementation improves yolk fatty acid profile in aged laying hens

Dandelion (Taraxacum Genus): A Review of Chemical Constituents and Pharmacological Effects

Contact Info

Product

Resources

About