Hypolipidemic Effect of Celastrus paniculatus in Experimentally Induced Hypercholesterolemic Wistar Rats

Patil, Ravindra H.; Prakash, K G; Maheshwari, Vijay L.

doi:10.1007/s12291-010-0050-x

Cited by 55 publications

(39 citation statements)

References 15 publications

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“…The significant reduction in body weight by the extract in female rats fed with high fat diet may be partly attributed to inhibition of cholesterol deposition in body tissues or inhibition of HMG CoA reductase activity which is the key regulatory enzyme in cholesterol biosynthetic pathway [1,2,27]. This implies that the extract may be recommended for persons who want to lose weight.…”

Section: Discussionmentioning

confidence: 99%

Hypolipidaemic Effect of Ethanol Leaf Extract of Moringa Oleifera Lam. in Experimentally induced Hypercholesterolemic Wistar Rats

Denen¹,

Eze²,

Adams³

et al. 2014

IJNFS

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Abstract:The hypolipidaemic effect of ethanol leaf extract of Moringa oleifera in experimentally induced hypercholesterolemic rats was investigated. Thirty six (36) wistar rats of both sexes weighing 130.53±4.86 were used for the study. The animals were completely randomized into six groups (A-F) comprising 6 animals each. Groups A, B and C comprise female rats administered 1 ml of distilled water, high dose of 600 mg/kg and low dose of 300 mg/kg body weight of the extract respectively. Groups D, E and F comprise male rats administered 1 ml of distilled water, high dose of 600 mg/kg and low dose of 300 mg/kg body weight of the extract respectively. Hypercholesterolemia was induced by feeding the animals with high fat diet for 21 days before administration of the extract. After the 21 days of feeding, administration of extract lasted for 14 days. Preliminary phytochemical screening revealed that the ethanol leaf extract of M. oleifera contains alkaloids, tannins, carbohydrates and cardiac glycosides. Only the high dose female group (600 mg/kg body weight) lost or maintained their body weight significantly (p<0.05), the rest did not. Body weight was not significantly (p>0.05) altered in the male group administered low dose and high dose, showing that the dose of the extract slightly affected their weight. For serum lipids, serum total cholesterol concentration in both male and female reduced significantly (p<0.05), both in those given low and high doses of the extract. Serum high density lipoprotein cholesterol (HDLC) level significantly (p<0.05) increased both in male and female rats that were administered high dose of 600 mg/kg body weight of the extract, but was not significantly (p>0.05) affected in other groups. Serum low density lipoprotein cholesterol (LDLC) level also reduced significantly (p<0.05) in both male and female rats that were administered high dose of the extract, but was not significantly (p>0.05) altered for those that received low doses (300 mg/kg body weight) of the extract. There was no significant (p>0.05) reduction in the LDLC of the male rats. Serum triacylglycerol (TAG) concentration in male and female rats reduced significantly (p<0.05), in those that received low and high doses of the extract. Overall, findings from the present study suggest that the ethanol leaf extract of M. oleifera has hypolipidaemic effect. Therefore, the leafy vegetable may be recommended to patients that have problems with high serum lipid profiles and also for people that want to lose or maintain body weight.

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Section: Discussionmentioning

confidence: 99%

Hypolipidaemic Effect of Ethanol Leaf Extract of Moringa Oleifera Lam. in Experimentally induced Hypercholesterolemic Wistar Rats

Denen¹,

Eze²,

Adams³

et al. 2014

IJNFS

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“…Compounds that play a role in lowering cholesterol might be alkaloids and non-alkaloids (Santoso et al, 2010), saponins (Son et al, 2007), polyphenol (Ngamukote et al, 2011;Zang et al, 2006), flavonoid (Shrime et al, 2011). Patil et al (2010) reported that the reduction of cholesterol and triglycerides by alkaloids were in part caused by the reduction of lipogenic enzymes activities and increased bile acid excretion in feces.…”

Section: Levels Of Fat Protein and Cholesterol Meatmentioning

confidence: 99%

“…In addition, the high fat content of meats reduce meat taste and increase the risk of metabolic diseases occurrences such as coronary heart disease (Tumova and Teimouri, 2010). In developed countries, consuming of high fat meats was positively correlated with an increase in the risk of incidence of metabolic diseases (Patil et al, 2010). Therefore, feeding low protein diets in broiler chickens needs to be balanced by feed supplement to inhibit rapid deposition of fat.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sauropus Androgynus Leaves Extract (Sale) on Fat Deposition in Broiler Fed Low Protein Diets

Santoso

Kususiyah

Fenita

2013

J. Indonesian Trop. Anim. Agric.

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ABSTRAKPenelitian ini dirancang untuk mengevaluasi efektivitas ekstrak daun katuk (EDK) untuk menurunkan penimbunan lemak pada broiler yang diberi pakan berprotein rendah. Delapan puluh empat broiler jantan dan betina (1:1) umur 20 hari didistribusikan ke dalam 7 kelompok perlakuan sebagai berikut: 1) Broiler dengan pakan mengandung 19% protein tanpa ekstrak daun katuk (EDK)/kg (P0); 2) Broiler dengan pakan mengandung 19% protein plus 4,5 g EDK/kg (P1); 3) Broiler dengan pakan mengandung 17% protein plus 4,5 g EDK/kg (P2); 4) Broiler dengan pakan mengandung 15% protein plus 4,5 g EDK/kg (P3); 5) Broiler dengan pakan mengandung 19% protein plus 9 g EDK/kg (P4); 6) Broiler dengan pakan mengandung 17% protein plus 9 g EDK/kg (P5); 7) Broiler dengan pakan mengandung 15% protein plus 9 g EDK/kg (P6). Hasil penelitian menunjukkan bahwa suplementasi ekstrak daun katuk dalam pakan berprotein rendah berpengaruh tidak nyata terhadap warna daging, cacat dada, bau karkas, dan fatty liver score (P>0,05) tetapi berpengaruh nyata terhadap cacat paha (P<0,01), warna kaki, rasa dan bau daging (P<0,05). Selain itu, suplementasi ekstrak daun katuk berpengaruh nyata terhadap kadar lemak (P<0,05) dan sangat nyata terhadap kadar kolesterol daging (P<0,01), tetapi berpengaruh tidak nyata (P>0,05) terhadap kadar protein dan komposisi asam lemak daging. Disimpulkan bahwa suplementasi ekstrak daun katuk pada dosis 9 g/kg pakan mampu menormalkan deposisi lemak pada broiler yang diberi pakan berprotein rendah. Ekstrak katuk juga mampu memperbaiki mutu karkas broiler. Kata kunci: esktrak daun katuk, penimbunan lemak, protein rendah, broiler ABSTRACTThe present study was designed to evaluate the effect of Sauropus Androgynus Leaves Extract (SALE) on broiler chickens fed low protein diets. Eighty four mixed broiler chickens (male:female = 1:1) aged 20 days were distributed to seven treatment groups as follows: 1) Broilers fed 19% protein without SALE (P0); 2) Broilers fed 19% protein plus 4.5 g SALE/kg (P1); 3) Broilers fed 17% protein plus 4,5 g SALE/kg (P2); 4) Broilers fed 15% protein plus 4.5 g SALE/kg (P3); 5) Broilers fed 19% protein plus 9 g SALE/kg (P4); 6) Broilers fed 17% protein plus 9 g SALE/kg (P5); 7) Broilers fed 15% protein plus 9 g SALE/kg (P6). Experimental results showed that supplementation of Sauropus androgynus extract to low protein diets had no effect on meat colour, haemorrhages scale in breast meat, and fatty liver score (P>0.05), but it significantly affected haemorrhages scale in thigh meat (P<0,01), shank colour, meat taste and flavour (P<0.05). In addition, supplementation of the extract significantly affected meat fat content (P<0.05) and meat cholesterol content (P<0.01), but it had no effect on meat protein content (P>0.05). It can be concluded that the leaves extract of Sauropus androgynus supplementation at level of 9 g/kg diets normalized fat deposition in broiler chickens fed low protein diets. SALE improved broiler meat qualities.

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“…The various parts such as bark, leaves, and fruits are used in traditional medicine system for various ailments. The bark powder has been found to possess various medicinal properties including cardioprotective properties, anti-ischemic, antioxidant [14], hypercholesterolemia effect [15], antimicrobial [16,17], anti-inflammatory, immunomodulatory, and antinociceptive activity [18]. It is also useful to cure obesity, hypertension, and hyperglycemia [19].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Antioxidant, Chemical Constituents, and Cytotoxicity Evaluation of Terminalia Arjuna (Roxb. Ex Dc.) Wight and Arn

Khatri¹,

Phougat²,

Dangi³

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study is to evaluate the in vitro antibacterial and antioxidant prospective of Terminalia arjuna (leaves). The most active extracts were examined for their chemical composition and cytotoxicity.Methods: The antibacterial activity of five different extracts were examined against 8 bacterial strains (5 Gram-positive and 3 Gram-negative) using resazurin-based microtiter dilution assay (RMDA) and disk-diffusion assay. The antioxidant potential of five extracts was demonstrated using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay and superoxide radical scavenging assay. Chemical composition and cytotoxicity were assessed using gas chromatography-mass spectrometry (GC-MS) and hemolytic assay, respectively.Results: According to RMDA, the acetone extract (AE) exhibited highest antibacterial activity. The AE showed highest activity against Salmonella enterica ser. typhi and Bacillus cereus with minimum inhibitory concentration, i.e., 195.31 μg/ml. In DPPH assay, AE showed the highest radical scavenging activity with inhibition concentration 50 23.09 μg/ml. In GC-MS analysis, the principal compound in AE was celidoniol (8.72 %). According to the results of hemolytic assay, the AE showed non-toxic behavior upto 500 μg/ml. Conclusion:The present investigation represents T. arjuna as an incredible herb. The AE was found to possess promising antibacterial and antioxidant properties.

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Hypolipidemic Effect of Celastrus paniculatus in Experimentally Induced Hypercholesterolemic Wistar Rats

Cited by 55 publications

References 15 publications

Hypolipidaemic Effect of Ethanol Leaf Extract of Moringa Oleifera Lam. in Experimentally induced Hypercholesterolemic Wistar Rats

Hypolipidaemic Effect of Ethanol Leaf Extract of Moringa Oleifera Lam. in Experimentally induced Hypercholesterolemic Wistar Rats

Effect of Sauropus Androgynus Leaves Extract (Sale) on Fat Deposition in Broiler Fed Low Protein Diets

Antibacterial, Antioxidant, Chemical Constituents, and Cytotoxicity Evaluation of Terminalia Arjuna (Roxb. Ex Dc.) Wight and Arn

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