Hypolipidemic, Hypoglycemic and Antioxidant Activities of Flower Extracts of &lt;i&gt;Allamanda violacea&lt;/i&gt; A.DC. (Apocynaceae)

Sethi, Arun; Prakash, R.; Bhatia, Akriti; Bhatia, Gitika; Khanna, Ashok; Srivastava, Swayam Prakash

doi:10.4314/tjpr.v11i2.8

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…In this 18-h acute experiment, hyperlipidemia was induced by the administration of triton WR-1339 [12][13][14][15] (Sigma chemical company, St. Louis, MO, USA) intraperitoneally at a dose of 400 mg/kg body weight to rats of all the groups except the control group. The compounds were macerated with gum acacia suspended in water (0.2 % w/v) and fed orally simultaneously with triton at a dose of 100 mg/kg [16,17] and the diet was withdrawn. Rats of the control and triton-treated groups were given the same amount of the gum acacia suspension (vehicle).…”

Section: Lipid Lowering Activity In Triton-induced Hyperlipidemic Ratsmentioning

confidence: 99%

Antidyslipidemic and Antioxidant Effects of Novel Lupeol‐Derived Chalcones

Srivastava

Mishra

Tiwari

et al. 2013

Lipids

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A series of Lupeol-based chalcones have been synthesized aiming to enhance the therapeutic efficacy of parent compound, the novel compounds were evaluated for their antidyslipidemic activity in triton-WR 1339 induced hyperlipidemic rats. Among the ten synthesized chalcones, the most active K4, K8, and K9 reversed the plasma levels of TC by (24, 25, 27 %), phospholipid by (25, 26, 25 %) and triacylglycerol by (27, 24, 24 %) respectively. In addition, the compounds showed significant in vitro antioxidant activity. The lipid lowering activity of these compounds were mediated through lipoprotein lipase activation (12-21 %) and enhanced post-heparin lipolytic activity (15-16 %). The compounds also displayed noteworthy inhibitory effect on 3-hydroxy-3-methyl-glutaryl reductase activity (in vitro). The in vitro effect of the most active compounds on MDI-induced adipogenesis using 3T3-L1 preadipocytes at 10 and 20 μM concentrations showed significant inhibition (20-32 %) of adipogenesis.

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Section: Lipid Lowering Activity In Triton-induced Hyperlipidemic Ratsmentioning

confidence: 99%

Antidyslipidemic and Antioxidant Effects of Novel Lupeol‐Derived Chalcones

Srivastava

Mishra

Tiwari

et al. 2013

Lipids

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“…Thankamani et al ( 2011) evaluated different solvents in the production of floral extracts from Alstonia scholaris (Apocynaceae), where they obtained a yield of 8.6 g% (hexane), 3.8 g% (benzene), 3.41 g% (propanol), 3.41 g% (ethyl acetate), 0.57 g% (methanol), 0.66 g% (acetonitrile) and 23.04 g% (water). Sethi (2012) evaluating different fractions of the floral hydroethanolic extract of Allamanda violacea obtained the following yields: petroleum ether 0.052%, ether 0.115%, chloroform 0.092%, chloroform:methanol 0.083%, and chloroform:methanol 0.068%.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and physicochemical evaluation, and photoprotection, antioxidant, antifungal, and antibacterial activities of the floral extract of Schubertia grandiflora Mart. & Zucc. (Apocynaceae)

et al. 2022

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Schubertia grandiflora is a species belonging to the floral of the Cerrado domain, presented annually with aromatic flowers. The study aimed to evaluate the hydroethanolic floral extract of S. grandiflora for phytochemistry, physicochemical and photoprotection, antioxidant, antifungal and antibacterial activities. Fresh flowers were collected and the floral extract produced by maceration. Qualitative phytochemical tests were carried out for the main phytochemical classes, organoleptic physico-chemical parameters, extract mass, moisture content, pH, relative density, refractive index, phenolic and total flavonoid contents, color density, Hue tint, and tests biological factors for protection factor, DPPH free radical reduction activities, antifungal and antibacterial. Phytochemistry has demonstrated the presence of several groups of important metabolites mainly in pharmaceutical use, visual color of the citrus yellow floral extract, aromatic and homogeneous, extract mass = 12.57%, moisture content = 6.21%, pH = 5.85, refractive index = 1.4217 nD, relative density 0.9044 g mL-1 20 °C, total phenolics = 238.83 mg GAE 100 g-1 dried extract, total flavonoids = 17.93 mg QC 100 g-1 dried extract, color density = 1.05, Hue color = 8.24, protection factor UVA and UVC, antioxidant activity with CI50 = 9.44 µg mL-1. Antifungal activity demonstrated inhibition zone only for Candida tropicalis between 10-6 mm and for Candida krusei between 18-5 mm, and antibacterial for Escherichia coli between 13-7 mm, Pseudomonas aeruginosa between 21-5 mm and Enterococcus faecalis between 32-17 mm. The hydroethanolic floral extract of Schubertia grandiflora demonstrated potential biological activities, characterizing this natural product for the development of pharmaceutical, biological and agricultural formulations.

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“…Plants of this family have been traditionally used for their anti-inflammatory, anti-tumours (Chopra et al 1956;Ahmad, Usmaghani, et al 1983, 1988Ahmad, Noorwala, et al 1993;Masoodi et al 2008;Mahmood et al 2010), immunostimulant (Pan et al 2003(Pan et al , 2013, antidiabetic (Noor et al 2013), anti-oxidant, antimicrobial, anti-complementary, antiepileptic and antineoplastic activities (Piacente et al 1998;Sethi et al 2008Sethi et al , 2012Sethi et al , 2013MacLeod et al 1997). In the search of these novel compounds, various species of the genus Hoya have been examined chemically and a number of biologically active steroids and their glycosides have been isolated (Mahmood et al 2012;Dembitsky et al 2004).…”

Section: Introductionmentioning

confidence: 98%

Two novel steroidal derivatives from chloroform-soluble extract of Hoya longifolia

Srivastava

Gupta

Khare

2015

Natural Product Research

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The structures of two novel steroidal derivatives (1 and 4) were elucidated. Steroidal derivatives namely fologenin (1) and hoyagenin (4) have been isolated from chloroform-soluble extract of the whole plant of Hoya longifolia (family: Asclepiadaceae), and their structures were determined by using (1)H NMR, (13)C NMR, (1)H-(1)H COSY and FAB-MS techniques as well as chemical degradation and derivatisation.

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Hypolipidemic, Hypoglycemic and Antioxidant Activities of Flower Extracts of <i>Allamanda violacea</i> A.DC. (Apocynaceae)

Cited by 4 publications

References 23 publications

Antidyslipidemic and Antioxidant Effects of Novel Lupeol‐Derived Chalcones

Antidyslipidemic and Antioxidant Effects of Novel Lupeol‐Derived Chalcones

Phytochemical and physicochemical evaluation, and photoprotection, antioxidant, antifungal, and antibacterial activities of the floral extract of Schubertia grandiflora Mart. & Zucc. (Apocynaceae)

Two novel steroidal derivatives from chloroform-soluble extract of Hoya longifolia

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