Hypolipidemic mechanism of oryzanol components- ferulic acid and phytosterols

Bhaskaragoud, G.; Rajath, S.; Mahendra, Vito; Kumar, Gajendra; Krishna, A. G. Gopala; Kumar, G. Suresh

doi:10.1016/j.bbrc.2016.05.053

Cited by 43 publications

(27 citation statements)

References 37 publications

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“…2 Gamma oryzanol was reported to have some biological properties, such as antioxidant, 1 anti-inflammation, 3 cardioprotection, 4 and hypolipidemic. 5 One of the contents of rice bran oil is gamma oryzanol with a concentration concentration between 1.5 -3%. 6 Gamma oryzanol is a chemical compound that is mostly composed of the complex ester trans-ferulate (trans-hydroxy cinnamic acid) with phytosterols (sterols and alcohol triterpene), including cycloartenol, β-sitosterol, 24-methylene cycloartenol ferulate and predominant campesterol.…”

Section: Introductionmentioning

confidence: 99%

Enrichment of the Gamma Oryzanol Level from Rice Bran by Addition of Inorganic Salts on Ionic Liquid 1-Butyl-3- Methylimidazolium Hexafluorophosphate ([BMIM] PF6) Extraction

Trinovita

Sutriyo²,

Saputri³

et al. 2017

JYP

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Objective: Rice bran oil has many helath benefit. The biologically active compounds of rice bran oil are fatty acids, squalene, tocopherols, phytosterols, tocotrienols, oryzanol, and polyphenols. Gamma oryzanol is a combination of at least 10 components of ferulic acid esters and alcohols triterpene. Gamma oryzanol has pharmacological activity includes cardiovascular disease, antioxidant, anticancer, antidiabetic, antiulcerogenic, neuroprotective and action immunomodulator. Ionic liquids are an environmentally friendly solvent used in the extraction and separation of bioactive compounds from plants. This study was conducted to evaluate the effect of inorganic salts addition on ionic liquid [Bmim]PF 6 in increasing levels of gamma oryzanol from rice bran. Method: In the experiments, IL [Bmim]PF 6 -MAE method was used to separated gamma oryzanol compound, and then was partitioned with hexane after the addition of inorganic salts: KH 2 PO 4, NaCl, NaNO 3 and Na 2 CO 3 , respectively. Gamma oryzanol content was determined by HPLC analysis. A mixture of mobile phase (methanol:acetonitrile:isopropan ol (5:4:1) and isocratic conditions at a wavelength of 327 nm. The flow rate is set at 1 ml / min..Results: The highest levels of γ-oryzanol was produced from the addition in KH 2 PO 4 + : This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Section: Introductionmentioning

confidence: 99%

Enrichment of the Gamma Oryzanol Level from Rice Bran by Addition of Inorganic Salts on Ionic Liquid 1-Butyl-3- Methylimidazolium Hexafluorophosphate ([BMIM] PF6) Extraction

Trinovita

Sutriyo²,

Saputri³

et al. 2017

JYP

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“…This signifies both hyperlipidemia and hyperglycemia conditions helping in the enhanced expression of TGF‐β while treatment with OC reduced lipid profile as well as blood glucose that downregulated the expression of TGF‐β. Several reports claim the involvement of SREBP1 in the development of diabetic nephropathy . It has been confirmed in several diabetic models such as STZ, ob/ob , and OVE26 mice .…”

Section: Discussionmentioning

confidence: 76%

“…Several research groups have shown reduced diabetic neuropathy and diabetic nephropathy by treating with 50 mg or 100 mg kg −1 of oryzanol isolated from crude rice bran oil tested and attributed for its free radical scavenging properties . Our previous studies on OC prepared from crude rice bran oil showed hypolipidemic properties and its involvement in the mechanisms for lowering lipid profile in high fat fed rats was also well demonstrated . In the recent studies that showed accumulation of fat during diabetic nephropathy is well addressed in various animal models including STZ‐induced animals .…”

Section: Discussionmentioning

confidence: 94%

Hypolipidemic and Antioxidant Properties of Oryzanol Concentrate in Reducing Diabetic Nephropathy via SREBP1 Downregulation Rather than β‐Oxidation

Bhaskaragoud

Geetha

Sharanappa

et al. 2018

Molecular Nutrition Food Res

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“…() and Bhaskaragoud et al . () who have reported effect of guggulsterone , cow ghee and rice bran oil on TC, respectively. Further, comparable ( P > 0.05) results of liver TC in H‐EG and H‐NEG revealed no significant effect of encapsulating guggul in double emulsion matrix.…”

Section: Resultsmentioning

confidence: 99%

“…(), respectively. Oryzanol in rice bran oil present in spread may have further contributed to inhibition of this enzyme (Bhaskaragoud et al ., ), thus exerting role in overall cholesterol management along with guggul . The other major fat present in spread, that is ghee, however, did not exert any effect on the gene inhibition (Sharma et al ., ).…”

Section: Resultsmentioning

confidence: 99%

Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats

Lamba

Sabikhi

Aggarwal

et al. 2017

Int J of Food Sci Tech

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Summary Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones, especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavailability of the herb guggul in in vivo rat model. The effect of the different diets with encapsulated and nonencapsulated guggul was evaluated and compared after 6 weeks, based on the final body weight and analysis of organs, serum and faeces of normal and hypercholesterolaemic (H) rats. It was evident from the results that double emulsion‐encapsulated guggul showed better control on weight of H rats (25.98% lower), inhibition of HMG CoA reductase (3.95 times less) activity and reduction in atherosclerotic index (47.2%), as compared to diet with unencapsulated guggul. Encapsulation of guggul also improved faecal excretion of bile acids, lipids and total cholesterol in H and normal rats.

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Hypolipidemic mechanism of oryzanol components- ferulic acid and phytosterols

Cited by 43 publications

References 37 publications

Enrichment of the Gamma Oryzanol Level from Rice Bran by Addition of Inorganic Salts on Ionic Liquid 1-Butyl-3- Methylimidazolium Hexafluorophosphate ([BMIM] PF6) Extraction

Enrichment of the Gamma Oryzanol Level from Rice Bran by Addition of Inorganic Salts on Ionic Liquid 1-Butyl-3- Methylimidazolium Hexafluorophosphate ([BMIM] PF6) Extraction

Hypolipidemic and Antioxidant Properties of Oryzanol Concentrate in Reducing Diabetic Nephropathy via SREBP1 Downregulation Rather than β‐Oxidation

Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats

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