Hypomagnesemia Associated with a Proton Pump Inhibitor

Matsuyama, Jun; Tsuji, Kiichiro; Doyama, Hisashi; Kim, Fae; Takeda, Yasuhito; Kito, Yosuke; Ito, Renma; Nakanishi, Hiroyuki; Hayashi, Tomoyuki; Waseda, Yohei; Tsuji, Shigetsugu; Takemura, Kenichi; Yamada, Shinya; Okada, Toshihide; Kanaya, Honin

doi:10.2169/internalmedicine.51.7748

Cited by 23 publications

(13 citation statements)

References 13 publications

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“…Yet, significant differences (p<0.05) between female consumers and no consumers were found in all variables, supporting findings from van der Hoorn study (30), and suggesting that the prescription of A02B medication group should be especially careful when prescribing in middle aged or elderly females. We believe that significant differences (p<0.05) found in Hand grip isometric muscle strength in total and in gender based, could be linked to the possible association between PPI usage and hypomagnesemia which is related to muscle cramps, something that has been proofed previously by Furlanetto & Faulhaber and Matsuyama et al (31, 32). …”

Section: Discussionsupporting

confidence: 61%

Musculoskeletal Health of 40-65 Year Old Males and Females in Kosova and the Impact of N05B, A02B (PPI, H2RA), H02AB and Lifestyle Factors on It

Krasniqi

Koni

Tschan

et al. 2016

Med Arh

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Background:This observational, cross-sectional study investigates the impact of medication usage, physical activity (PA) and nutritional status on musculoskeletal health (MSH) in males and females aged 40-65 in the population of a post conflict, developing country.Methods:Bone Mineral Density (BMD), T-score and Z-score at distal forearm regions (measured by DEXA scan), together with isometric hand grip strength (dynamometer) were evaluated in a total of 162 subjects (53 Males, average age 55.15±7.12 and 109 Females, 54.27±5.1). Additionally, bio-anthropometric assessments, medication usage, PA level and nutritional status were assessed.Results:Significant differences (p<0.05) were found in total subjects Body Mass Index (BMI), PA, BMD, T-score and Hand grip between genders. 42% of total participants met the diagnostic criteria of, out of which 6.8% with T-score below -2, while no cases of Osteoporosis was recorded. N05B Anxiolytics and A02B Drugs for peptic ulcer and gastro-oesophageal reflux disease medication groups consumption turned to have no significant differences (p>0.05) in BMD, T-score, and hand grip in total population, except for A02B where p<0.05 were found in Hand grip, as well as between female consumers and no consumers in all variables. Meanwhile, in total subjects consuming H02AB Glucocorticoids p<0.05 were observed in BMD and T-score, but not on hand grip.Conclusions:This study shows a low risk for MSH problems amongst the studied population in Kosova, while the consumption of H02AB medication group in both genders and A02B in females only for extended periods might effect MSH, therefore appropriate benefit/risk assessment should be made before prescribing these medications, notwithstanding age, gender, PA or nutritional status.

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Section: Discussionsupporting

confidence: 61%

Musculoskeletal Health of 40-65 Year Old Males and Females in Kosova and the Impact of N05B, A02B (PPI, H2RA), H02AB and Lifestyle Factors on It

Krasniqi

Koni

Tschan

et al. 2016

Med Arh

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“…However, most studies suggest that PPIs likely do not affect vitamin D status [36].The major function of Mg is in bone formation and in ATP reactions [37]. Several articles report hypomagnesemia in long-term PPI treatment [38][39][40][41]. A recent meta-analysis article also reported that PPI use is associated with increased odds of hypomagnesemia, perhaps due to PPIs "aggravating" the TRPM6/TRPM7 genes that may lead to decreased magnesium intestinal absorption [42].…”

Section: Possible Mechanisms For Nutritional Deficiencies Associamentioning

confidence: 99%

“…The DRIs also suggest that Mg intake is low, absorption is decreased, and urinary Mg is increased in elderly people [37]. Therefore, the monitoring of serum magnesium levels should be considered in patients with chronic use of PPIs or GERD, since it is likely that there is a dose-response relationship [38,42]. The current treatment for hypomagnesemia associated with PPIs is magnesium supplementation and discontinuation of the PPI.…”

Section: Possible Mechanisms For Nutritional Deficiencies Associamentioning

confidence: 99%

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Nutritional Deficiencies Associated with Gastroesophageal Reflux Disease (GERD) in Elderly/Older Adults

Burns‐Whitmore¹,

Froyen²

2020

GGR

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Introduction: Gastroesophageal reflux disease (GERD) is the most common upper gastrointestinal disorder encountered in the elderly patient. GERD is one of the highly prevalent diseases seen in the clinical practice. In the elderly population, few studies have addressed the prevalence of GERD. It is estimated that 20-30% of the US population experience weekly symptoms of GERD, and two out of five people experience heartburn or acid regurgitation at least once a month. Methods: To ensure peer-review articles were used, the search engine, PubMed was utilized along with medical reference-related websites and US Department websites as well as professional organizations. Some medications used by older adults may promote acid reflux, prescription treatments include proton pump inhibitors (PPIs), coating agents, H2 blockers and over-the-counter medications that contain antacids or decreased dosages of the prescription strength H2 blockers and PPIs. Discussion: Decreased stomach acidity could be responsible for risk of nutrient deficiencies including vitamin B12 (cobalamin), vitamin C (ascorbate), calcium, iron and magnesium deficiencies or medications that are used to alleviate the symptoms of GERD may also be responsible for increasing the risk for deficiencies. The purpose of this review is to demonstrate and provide reasons why regular assessment, screening, testing, and/or clinically evaluating nutritional deficiencies common in older adults and relating to physical pathogenesis and/or drug treatments of GERD, should be added to the GERD treatment protocol for older adults.

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“…Međutim, poslednjih nekoliko godina se često prijavljuju slučajevi hipomagnezemije pri dugotrajnoj terapiji IPP, nakon što je u martu 2011. godine FDA ukazala na ovaj problem [41]. Hipomagnezemija može proticati asimptomatski, ili izazvati različitu simptomatologiju, od nauzeje, preko mišićnih spazama, artritisa, tremora, pa do konvulzija [42][43][44] . Nastala hipomagnezemija, praćena je i hipokalcemijom, kao i hipoparatireoidizmom [45,46].…”

Section: Potencijalni Rizici Primene Inhibitora Protonske Pumpeunclassified

Inhibitori protonske pumpe – primena i bezbednost

Rašić

Hudomal

et al. 2013

Biomedicinska istraž.

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Kratak sadržajUvod. Inhibitori protonske pumpe (IPP) primenjuju se u terapiji acido peptičkih poremećaja uključujući peptički ulkus, gastroezofagusni reflex, erozivni i neerozivni ezofagitis, Zollinger-Elissonov sindrom, Helicobacter pylori infekcije i profilaksu stres ulkusa. Dobro dokumentovana efikasnost i relativna bezbednost primene, doprineli su značajnom propisivanju IPP u praksi. Neželjena dejstva IPP nisu ozbiljna i javljaju se kod približno 1-3% lečenih pacijenata, bez značajnijih razlika među pojedinačnim predstavnicima. Dugotrajna terapija IPP povećava rizik od razvoja rebound hipersekrecije želudačne kiseline, pneumonije i enteralnih bakterijskih infekcija (dijareja izazvana sa Clostridium difficile), preloma kostiju i kardiovaskularni rizik pri istovremenoj primeni sa klopidogrelom. IPP ne izazivaju deficit gvožđa i vitamina B12, ali povećavaju rizik od razvoja hipomagnezemije. Većina iznetih podataka potiče iz retospektivnih kohort i case-control studija. Da bi se utvrdila tačna uzročno posledična povezanost između IPP i neželjenih događaja neophodno je sprovesti velika prospektivna, randomizirana, kontrolisana klinička ispitivanja. Mnogo racionalnija upotreba IPP smanjila bi troškove u zdravstvu i osigurala njihovu bezbedniju primenu.Ključne reči: inhibitori protonske pumpe, dugotrajna primena, neželjena dejstva UvodInhibitori protonske pumpe (IPP) predstavljaju najefikasniju grupu antisekretornih lekova, koji su za samo nekoliko godina postali lekovi prvog izbora za sva stanja koja su praćena hiperaciditetom tj. pojačanim lučenjem želudačne kiseline. Tako su glavne indikacije za njihovu primenu peptički ulkus, erozivni i neerozivni refluksni ezofagitis, Zollinger-Ellisonov sindrom, infekcija izazvana bakterijom Helicobacter pylori (u okviru kombinovane terapije), kao i profilaksa stres ulkusa. Derivat benzimidazola -omeprazol prvi je

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Hypomagnesemia Associated with a Proton Pump Inhibitor

Cited by 23 publications

References 13 publications

Musculoskeletal Health of 40-65 Year Old Males and Females in Kosova and the Impact of N05B, A02B (PPI, H2RA), H02AB and Lifestyle Factors on It

Musculoskeletal Health of 40-65 Year Old Males and Females in Kosova and the Impact of N05B, A02B (PPI, H2RA), H02AB and Lifestyle Factors on It

Nutritional Deficiencies Associated with Gastroesophageal Reflux Disease (GERD) in Elderly/Older Adults

Inhibitori protonske pumpe – primena i bezbednost

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