2007
DOI: 10.4103/1596-3519.55693
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Hyponatraemia during low-dose carbamazepine therapy

Abstract: We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-clonic seizures. Although asymptomatic, the biochemical abnormality improved after discontinuation of carbamazepine. Hyponatraemia developed after rechallenge with controlled release carbamazepine. The authors suggest that serum sodium levels be carried out before commencement of carbamazepine and caution be used in prescribing carbamazep… Show more

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Cited by 7 publications
(3 citation statements)
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“…The result of the present study also disagrees with that of [23], who obtained hyponatraemia following CBZ administration. According to [13], PHE exerts a transient inhibitory effect on ADH release by the posterior pituitary gland, and it increases water reabsorption in the collecting duct of the kidneys, PHE has also been shown to reverse the hyponatraemia induced by CBZ therapy.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…The result of the present study also disagrees with that of [23], who obtained hyponatraemia following CBZ administration. According to [13], PHE exerts a transient inhibitory effect on ADH release by the posterior pituitary gland, and it increases water reabsorption in the collecting duct of the kidneys, PHE has also been shown to reverse the hyponatraemia induced by CBZ therapy.…”
Section: Discussioncontrasting
confidence: 99%
“…Its main function is reduction of sustained repetitive firing in neurones by blocking voltage-gated sodium channels [14]. CBZ exerts its therapeutic effects through the inhibition of brain neuronal activities, used for the treatment of seizure disorders and trigeminal and other neuralgias [23]. Severe liver failure is much less common in individuals using the drug, but has been reported with CBZ therapy [27], implicated in the aetiology of immunological abnormalities with decreased IgG, IgA and IgM [9].…”
Section: Introductionmentioning
confidence: 99%
“…Dolayısıy-la OKBZ kullanımına bağlı uygunsuz ADH sendromu gelişi-mi, hiponatremi oluşumundan sorumlu tutulmaktadır. [18,19] OKBZ kullanımına bağlı ortaya çıkan hiponatremi çoğun-lukla asemptomatik seyreder. Ancak gözden kaçırıldığı veya uygun tedavi edikmediği durumlarda bulantı, kusma, bilinç değişikliği, nöbet, ensefalopati, görme bozuklukları ve hatta ölüm gibi ciddi komplikasyonlara neden olabilir.…”
Section: Discussionunclassified