Hyponatremia – an unusual trigger of Takotsubo cardiomyopathy

Santos, Mário; Dias, Vasco; Meireles, Ana Célia Maia; Gomes, Catarina; Luz, André; Mendes, Duarte; Caiado, Luísa; Carvalho, Henrique; Cabral, Sofia; Torres, Severo

doi:10.1016/j.repce.2011.11.003

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…The severity and velocity with which hypo-osmolality secondary to hyponatremia develops are likely to be a deciding factor for the occurrence of SCM, as chronic persistent hyponatremia is a less likely trigger 18 . Cardiac magnetic imaging suggesting myocardial edema has been reported in SCM, which could mean that some cell swelling attributed to hyponatremia could also induce myocardial damage and interfere with inotropism by modulation of cardiomyocyte Na+/Ca2+ exchange 19,20 .…”

Section: Discussionmentioning

confidence: 99%

Síndrome de Takotsubo (cardiomiopatía del estrés) y secreción inapropiada de hormona antidiurética

Murguía-Aranda¹,

Castañón-González²,

Shuchleib-Cukiert³

et al. 2021

CIRU

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Takotsubo syndrome is a form of acute reversible left ventricular dysfunction in the absence of coronary obstruction. An 85-year-old lady with a medical history of transcatheter aortic valve replacement was readmitted complaining of 2 weeks of severe pain by a displaced hip and failed osteosynthesis. While she was scheduled for hip surgery, severe hyponatremia secondary to inappropriate antidiuretic hormone secretion was documented, and sudden-onset pulmonary edema ensued. Echocardiography confirmed normally functioning aortic prosthetic valve and classical features of Takotsubo. She was treated with non-invasive mechanical ventilation, water restriction, and diuretics. Hyponatremia and the cardiomyopathy resolved and the patient recovered completely.

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Section: Discussionmentioning

confidence: 99%

Síndrome de Takotsubo (cardiomiopatía del estrés) y secreción inapropiada de hormona antidiurética

Murguía-Aranda¹,

Castañón-González²,

Shuchleib-Cukiert³

et al. 2021

CIRU

View full text Add to dashboard Cite

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“…Reports of hyponatremia induced cardiac manifestations are rare and less recognized. There are a few reports of association of hyponatremia as a possible trigger for precipitating Tako-tsubo cardiomyopathy (TCM) [1][2][3][4][5][6].TCM is characterized by transient, acute left ventricular dysfunction with apical ballooning. It typically affects elderly women, but the exact pathophysiology is not well understood.…”

mentioning

confidence: 99%

“…Though often mild and clinically insignificant; in severe forms, it can cause altered sensorium, seizures, and other neurological manifestations. Although hyponatremia induced cardiac manifestations are rare, they have been cited in a few case reports of TCM [1][2][3][4][5][6].…”

mentioning

confidence: 99%