Hyponatremia, bone mineral density and falls in the elderly; Results from AHAP study

Hosseini, Seyed Reza; Baghitabar, Naghi; Mirzapour, Ali; Oliaei, Farshid; Nooreddini, Hajighorban; Bijani, Ali; Mouodi, Simin

doi:10.1515/rjim-2017-0032

Cited by 7 publications

(28 citation statements)

References 22 publications

(30 reference statements)

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“…Of 216 retrieved articles, 201 articles were excluded for different reasons. The flow of the meta‐analysis is summarized in Figure , and the characteristics of the studies included in the meta‐analysis are summarized in Table and . Overall 23 full‐text articles were considered potentially eligible for the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

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Hyponatremia, falls and bone fractures: A systematic review and meta‐analysis

Corona

Norello

Parenti

et al. 2018

Clinical Endocrinology

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Section: Resultsmentioning

confidence: 99%

“…The flow of the meta-analysis is summarized in Figure 1, and the characteristics of the studies included in the meta-analysis are summarized in Table 1 and 3. 5,7,8,[16][17][18][19][20][21][22][23][24][25][26][27] Overall 23 full-text articles were considered potentially eligible for the meta-analysis.…”

Section: Re Sultsmentioning

confidence: 99%

Hyponatremia, falls and bone fractures: A systematic review and meta‐analysis

Corona

Norello

Parenti

et al. 2018

Clinical Endocrinology

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“…Acute hyponatremia can be fatal; but of equal concern is the fact that chronic hyponatremia can result in gait deficits, cognitive impairment, and loss of balance, thus predisposing the elderly to increased risk of falls leading to bone fractures. Indeed, hyponatremia is an independent risk factor for increased mortality in the elderly . The high prevalence of hyponatremia in the elderly remains unexplained.…”

Section: Discussionmentioning

confidence: 99%

Aging increases the expression of vasopressin receptors in both the kidney and urinary bladder

Birder

Jackson

Wein

et al. 2018

Neurourology and Urodynamics

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Aims: The goal of this study was to determine whether aging effects the expression of V 1a and V 2 vasopressin receptors in the urinary bladder mucosa (UBM) and kidney. Methods: UBM and kidneys were obtained from young (3 months-of-age) and old (25-30 months-of-age) female Fisher 344 rats. Tissue samples were analyzed by western blotting for V 1a and V 2 receptor expression, and rat plasma levels of vasopressin levels were measured by ELISA. Results: V 1a and V 2 receptors were detected in both the UBM and kidneys. Aging significantly (P < 0.05) increased the expression of V 2 receptors by 2.80 ± 0.52 and Neurourology and Urodynamics. 2019;38:393-397.wileyonlinelibrary.com/journal/nau

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“…Twenty articles published between 2008 and 2020 were included (3,9,(18)(19)(20)35,36,40,(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55). Three were prospective cohort study (3,20,40,51).…”

Section: Hyponatremia Osteoporosis and Fracturesmentioning

confidence: 99%

Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

Fratangelo

Nguyen

2022

Preprint

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Purpose. Hyponatremia is frequent in older age, whether it is a key player, a surrogate marker, or an innocent bystander in age related diseases is still unclear. Method. To further understand the role of hyponatremia in falls, osteoporosis, fractures, and cognitive impairment in old patients, we conducted a systematic literature review. The protocol of this study is available on the International prospective register of systematic reviews (PROSPERO, number CRD42021218389). MEDLINE, EMBASE and PsycINFO database were searched. Three reviewers identified studies meeting inclusion criteria and check decisions. Each study was independently evaluated by two reviewers, discrepancies between the two reviewers were solved by the third. Two hundred and fifteen articles were retrieved. Thirty-two were included in the review. Results. The majority of the studies found a significant association between hyponatremia and falls even after correction for confounding factors. Some studies suggested an association between persistent hyponatremia and increased osteoporosis and fracture risk. On the contrary, the evidence of an association between hyponatremia and cognitive impairment is lacking. Conclusion. Here we suggest that hyponatremia may be regarded as a marker of unhealthy aging and a confounder rather than a causal factor or an innocent bystander for falls and fractures. As regards cognitive impairment, the evidence provided until now, are not sufficient to explain a real role of hyponatremia that may be regarded rather as an innocent bystander in neurodegeneration.

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Hyponatremia, bone mineral density and falls in the elderly; Results from AHAP study

Abstract: HN was not a prevalent problem in older adults who met the inclusion criteria of this research. No significant difference has been observed between HN and bone mineral density and falls in the elderly.

Cited by 7 publications

References 22 publications

Hyponatremia, falls and bone fractures: A systematic review and meta‐analysis

Hyponatremia, falls and bone fractures: A systematic review and meta‐analysis

Aging increases the expression of vasopressin receptors in both the kidney and urinary bladder

Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

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