Hyponatremia in systemic lupus erythematosus patients: Relation to disease activity and fatigue

EL-Badawy, Mohja A.; Elmahdi, Amira R; Elsherbiny, Dalia A.; Bawady, Somia

doi:10.1016/j.ejr.2019.01.001

Cited by 7 publications

(10 citation statements)

References 30 publications

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“…These findings are similar to the results of the aforementioned studies which concluded that hyponatremia in SLE is linked to higher SLE activity. 8,9 Yet, our results noted that the CRP level was not significantly correlated with sodium level; this contradicts with what was reported by other studies that considered the association between hyponatremia and CRP in inflammatory conditions in general acute illness through a transient stimulation of vasopressin secretion. 19,21 Meanwhile, our study revealed that only ESR was independently a risk factor for hyponatremia; this is inconsistent with the conclusion of EL-Badawy et al who demonstrated that CRP, SLEDAI, and consumed C4 were independent risk factors for hyponatremia.…”

Section: Discussioncontrasting

confidence: 99%

“…19,21 Meanwhile, our study revealed that only ESR was independently a risk factor for hyponatremia; this is inconsistent with the conclusion of EL-Badawy et al who demonstrated that CRP, SLEDAI, and consumed C4 were independent risk factors for hyponatremia. 9 Our data showed that steroid intake had no impact on the hyponatremia group. ESR was found to be a better predictor of hyponatremia with good performance at a cut-off value of 35.…”

Section: Discussionmentioning

confidence: 53%

“…This finding is matching with a recent study that stated that ESR can predict hyponatremia with best sensitivity (100%) and specificity (80%) but at a lower value (ESR ≥ 17.5). 9 In the light of these facts, we speculate the conception that lupus as an inflammatory disease is characterized by enhanced cytokines that may cause hyponatremia and high disease activity. 22 This observation may impact the clinical approach of hyponatremia management.…”

Section: Discussionmentioning

confidence: 91%

“…8 A recent study suggested that hyponatremia is associated with higher disease activity, fatigue development, and perception in lupus patients. 9 There is scarcity of data on the association of hyponatremia with lupus. Therefore, this descriptive crosssectional study was conducted to determine the prevalence of hyponatremia in lupus patients as well as its correlation with the disease activity and explore a new area of inquiry.…”

Section: Introductionmentioning

confidence: 99%

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<p>Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study</p>

Yamany

Behiry

Ahmed

2020

OARRR

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Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement. Hyponatremia is common in inflammatory diseases such as meningitis. Also, it has been found to be strongly associated with the degree of inflammation. However, it has not been fully evaluated in lupus. This study aimed to assess the inflammatory impact of hyponatremia in SLE patients and investigate its relationship with SLE disease activity. Patients and Methods: A total of 101 patients with SLE were enrolled in this study and divided into two groups according to Na level; a normo-natremic group and a hyponatremic group. Demographic and clinical data were collected. SLE activity was assessed by the systemic lupus erythematosus disease activity index (SLEDAI). The estimated sedimentation rate (ESR) as well as levels of C-reactive protein (CRP) and complements (C3 and C4) were measured. Results: The majority of patients were females (98 subjects) (97%) with a mean age of 33±8 years. Out of 101 participants, 40 patients (39.6%) were hyponatremic with a mean Na level of 131.58±3.11 mmol/L. There was a statistically negative correlation between both ESR and SLEADI score and Na level (r=−0.436 and −0.436, respectively) with p=0.002, whereas Na level was positively correlated with complements, Cl, and albumin levels (r=0.653, 0.314, and 0.460, respectively) (p=0.000, 0.027, and >0.001, respectively). CRP was not correlated with Na level. ESR was independently correlated with hyponatremia at the 95% CI for Exp B (0.997-0.058) with a p-value of 0.048. Conclusion: Hyponatremia could be used as an indicator of SLE activity. Also, it might be an easily and rapidly detected as well as a prognostically useful marker of inflammation.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study</p>

Yamany

Behiry

Ahmed

2020

OARRR

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“…Our study shows a high correlation between low serum sodium and decreased activity. One prior study suggested that low serum sodium is associated with higher disease activity and more perceived fatigue in patients with systemic lupus erythematosus [26]. Low serum sodium can reflect severe inflammation and could be considered a factor predisposing to fatigue [26].…”

Section: Discussionmentioning

confidence: 99%

Multidimensional fatigue in patients with nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: incidence, severity, and risk factors

Chen

Yang

Duan

et al. 2021

Support Care Cancer

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Purpose To explore the incidence, severity, and risk factors of multidimensional fatigue in patients with nasopharyngeal carcinoma (NPC) receiving concurrent chemoradiotherapy (CCRT). Methods This prospective study included 79 patients with NPC in Guangzhou (China) from June 2015 to July 2018. Data were collected before and after CCRT, including demographic and clinical characteristics, nutritional parameters, and fatigue scores, based on completion of the Multiple Dimensional Inventory-20 Questionnaire, with five subscales: General Fatigue, Mental Fatigue, Physical Fatigue, Reduced Activity, and Reduced Motivation. Results Increased general fatigue was found to be associated with lower lymphocyte count and body mass index <23 kg/m 2 . Increased physical fatigue was related to age > 42 years. Higher scores for reduced activity were associated with age > 42 years, female sex, and lower serum sodium. Increased mental fatigue was related with lower lymphocyte count and unemployment; and increased total fatigue was associated with lower lymphocyte count, age > 42 years, and 3-6 courses of treatment. Furthermore, 3-6 courses of treatment was an independent predictor of severe general fatigue, while age >42 years was an independent predictor of severe physical fatigue. Importantly, cancer stage IVB and 3-6 courses of treatment could predict severe total fatigue. Conclusions Our data demonstrate that fatigue is increased in all dimensions in NPC patients following CCRT, and that the predictors differ for each fatigue dimension. These results could guide the development of targeted interventions that may reduce the impact of cancer-related fatigue in patients with NPC.

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Lymphopenia in systemic lupus erythematosus patients: Is it more than a laboratory finding?

Sobhy

Niazy

Kamal

2020

The Egyptian Rheumatologist

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Hyponatremia in systemic lupus erythematosus patients: Relation to disease activity and fatigue

Cited by 7 publications

References 30 publications

<p>Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study</p>

<p>Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study</p>

Multidimensional fatigue in patients with nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: incidence, severity, and risk factors

Lymphopenia in systemic lupus erythematosus patients: Is it more than a laboratory finding?

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