Background Recent data display the possible role of cytokines such as interleukin-10 (IL-10), IL-17 and IL-23 as a link between dyslipidemia and atopy; however, the relationship between dyslipidemia, allergic rhinitis (AR), and the underlying mechanisms involved is unclear. Purpose To measure the lipid profile and IL-17A level in AR patients in comparison to healthy controls, and correlate serum lipid level with the severity of symptoms and quality of life (QoL) of AR patients. Patients and Methods Peripheral blood samples were collected from AR patients (n=70) and a control group (n=80). Samples were analyzed for serum total IgE by ELISA, serum lipid profile, and IL-17A level by ELISA. Severity of AR symptoms was assessed by visual analogue scale (VAS) score and the rhinoconjunctivitis QoL questionnaire. Results Serum lipid profile and level of IL-17A in AR patients were significantly higher in comparison to controls (P < 0.001). Positive correlations were found between total cholesterol (TC) and the severity of AR and QoL. IL-17A was positively correlated with triglyceride (TG) level and low-density lipoprotein cholesterol (LDL-C) (P=0.011, r =0.303; P=0.043, r =0.242, respectively). Additionally, IL-17A was negatively correlated with high-density lipoprotein cholesterol (HDL-C) level ( P =0.036, r =−0.251). IL-17A was positively correlated with both age and VAS score with statistical significance (P=0.033, r =0.225; P=0.011, r =0.302, respectively). Conclusion Dyslipidemia might play a potential role in the severity of AR symptoms and impairment of patients’ QoL. Highlighting this association might alert physicians to evaluate the lipid profile in AR patients for timely diagnosis and treatment of dyslipidemia in an attempt to improve disease control and improve QoL.

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Background: Well-known allergy tests are used to evaluate and diagnose allergic diseases. The aim of this study was to assess the role of serum level diamine oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy.Methods: This case-control study included 40 patients with respiratory allergies (atopic asthma and allergic rhinitis) as well as 40 age-and sex-matched controls. A detailed past medical history of allergy was collected from each participant including family history of allergy. Physical examination, pulmonary function test (PFT) and measurement of serum levels of total immunoglobulin E (IgE) and DAO were performed. Skin-prick test and specific IgE to common aeroallergens were also carried out.Results: DAO levels were higher in patients than controls. There was a positive correlation between severity of disease and DAO. No significant association was found between DAO level and age, type of respiratory allergy, duration of disease, PFT, eosinophilia, and total IgE. DAO had a high negative predictive value (94.7%) and high sensitivity (97.5%). Conclusion: DAO may be helpful in the assessment of severity and in ruling out respiratory allergy. C 2019 ARS-AAOA, LLC.R espiratory allergy is growing significantly. Estimations worldwide reveal that 5% to 12% of the population are asthmatic, whereas 20% have allergic rhinitis, which is the leading cause of decreased individual productivity. One study showed that around 45% of patients had not yet been diagnosed and that respiratory allergies were underdetermined. 1 Accurate screening and early diagnosis are crucial in the management of respiratory allergy.Mast cells are the main contributor of a typical allergic inflammatory reaction. These cells are activated by exposure to allergens, which, in turn, results in the release of many mediators including histamine, leukotrienes, and specific cytokines. 2 Histamine is the main biomarker of the

Background Although cumulative data strongly suggest an association between dyslipidemia and allergic disorders, especially asthma, evidence regarding allergic rhinitis (AR) is lacking. We aimed to assess frequency and associated risk factors of dyslipidemia among patients with AR. Methods The current study is a cross-sectional study that recruited 150 AR patients by systematic randomization. Blood samples for serum lipid profile, total immunoglobulin E (IgE) and serum interleukin-17A (IL-17A) were withdrawn from all patients. Results Dyslipidemia was prevalent in 84 AR patients (56%). Higher levels of total IgE, IL17-A, and sensitization to hay dust and mixed mites significantly increased the risk of dyslipidemia among AR patients by 1.004, 1.062, 4.057 and 3.652 respectively ( P < 0.05). Conclusion High serum total IgE level, high serum IL-17A level, and sensitization to hay dust and mixed mites are independent risk factors for dyslipidemia among AR patients.

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