Hypopharyngeal large cell neuroendocrine carcinoma

Lee, Wei-I; Ameratunga, Malaka; Plessis, Justin du; Gan, Hui

doi:10.1136/bcr-2015-211908

Cited by 5 publications

(8 citation statements)

References 27 publications

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“…Conversely, current literature includes only a limited number of pure hypopharyngeal NECs. 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 Table 1 summarises their main characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…These tumours often present as loco‐regionally advanced disease, that is, with cervical lymphadenopathies and more than 90% develops distant metastases. 26 Lee et al 16 described a case presenting with bone, liver and lung metastases, who died a few weeks after the second cycle of chemotherapy from presumed cardiopulmonary arrest. Takagawa et al 15 presented a patient who received neck dissection and multiple courses of CRT to the primary and to lung and bone metastases, who deceased 39 months after surgery.…”

Section: Discussionmentioning

confidence: 99%

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Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report

et al. 2021

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Background Primary neuroendocrine carcinomas (NECs) are very rare entities accounting for 0.49% of all malignancies. Within the head and neck, the most common sites are the larynx and paranasal sinuses, while the hypopharynx is seldom described. Case We present a patient with a poorly differentiated metastatic NEC of the hypopharynx treated palliatively with organ‐preserving surgery and post‐operative chemotherapy, and literature review for well‐documented pure hypopharyngeal NECs. Our patient died of chest infection during chemotherapy, 4 months after surgery. Conclusion Chemotherapy remains the mainstay of treatment in the presence of metastases with 2‐year overall survival of 15.7%. Due to the aggressive nature of poorly differentiated metastatic NECs, surgical management is seldom considered. We report and advocate the successful palliative role of organ‐preserving, minimally invasive trans‐oral LASER micro‐surgery and neck dissection to control loco‐regional head and neck disease, safe‐guarding better quality of home life, despite limited life expectancy for this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report

et al. 2021

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“…Takagawa et al13 reported high Ki-67 positivity in a patient with primary hypopharyngeal NEC with distant metastases. Lee et al19 reported the case of a patient with a Ki-67 mitotic index that approached 70% and made the diagnosis of LCNEC of the hypopharynx. Nakahira et al15 also reported two cases of primary small cell carcinoma of the hypopharynx with high Ki-67 positivity.…”

Section: Discussionmentioning

confidence: 99%

<p>Primary poorly differentiated small cell type neuroendocrine carcinoma of the hypopharynx</p>

Zhou

2019

OTT

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The incidence of primary poorly differentiated neuroendocrine carcinoma (PDNC) of the hypopharynx iŝ4%. However, the disease pathogenesis, natural history, and prognostic factors remain poorly understood. We report the case of a 66-year-old man who presented with multiple metastases from primary PDNC of the hypopharynx. Physical examination revealed ã3×4 cm left cervical mass located at the level III, with tenderness and an unclear boundary. Laryngoscopy revealed a large mass arising from the posterior hypopharynx; glottis and vocal cord movements were invisible. After consultation with our head and neck oncological multidisciplinary team, diagnosis and specific treatment plan were made. Under general anesthesia, a biopsy sample was obtained via suspension laryngoscopy. Routine pathology revealed small cell carcinoma. Immunohistochemical staining identified neoplastic cells that were positive for cytokeratins, CD56, chromogranin A, and synaptophysin. The Ki-67 mitotic index approached 80%. These findings confirmed hypopharyngeal PDNC, and chemotherapy was prescribed. After 7 months, the tumor metastasized to the left side of the anterior chest wall, bilateral lungs, left liver, and skeleton. The soft tissue of the chest wall was biopsied, and pathology revealed PDNC. Subsequent examinations over the next 4 months confirmed multiple liver metastatic lesions. The patient succumbed to the cancer progression a month later. Here, we systematically review the clinical manifestations, pathogenesis, prognostic factors, and treatment of the disease. In conclusion, patients always have a poor prognosis due to a lack of optimal treatment.

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“…Small cell carcinoma (SCC) is one of many subtypes of NECC based on specific histologic and immunohistochemical properties [4-6]. SCC is most commonly found in the lung [1].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Human Papillomavirus-associated High-grade Neuroendocrine Carcinoma of the Hypopharynx

Sanwal¹,

Voorhees²,

Moon

et al. 2019

Cureus

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We present a case of primary small cell carcinoma of the hypopharynx (SCCH), with a rare association with human papillomavirus (HPV). A comparison is made to 11 previously known, well-documented cases of SCCH with a review of the literature concerning SCCH. Our patient’s age of 23 years is the lowest among all previously reported cases, with an age range of 35-75. HPV association with SCCH is a rare new entity and eight HPV subtypes were identified in our case by ribonucleic acid (RNA) in-situ hybridization. The important common features among the previously reported 11 cases and our case include: (a) piriform sinus of the hypopharynx as the primary site in all cases, (b) a majority of patients presented with dysphagia and a neck mass, and (c) most patients had locoregional involvement at the time of presentation as opposed to distant metastasis. HPV-associated SCCH is extremely rare, with potentially aggressive clinical behavior, and needs much more research to further elucidate both the diagnostic and therapeutic approaches.

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Hypopharyngeal large cell neuroendocrine carcinoma

Cited by 5 publications

References 27 publications

Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report

Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report

<p>Primary poorly differentiated small cell type neuroendocrine carcinoma of the hypopharynx</p>

A Rare Case of Human Papillomavirus-associated High-grade Neuroendocrine Carcinoma of the Hypopharynx

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