Hypophysectomy Combined With Intrasellar Irradiation With Yttrium-90

Edelstyn, G.A.; Gleadhill, Colin A.; Lyons, A.R.; Rodgers, H. W.; Taylor, Amy; Welbourn, Richard

doi:10.1016/s0140-6736(58)90767-0

Cited by 24 publications

(7 citation statements)

References 2 publications

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“…In previous preliminary reports we concluded (1) that patients who had blood-borne metastases were more likely to respond to hypophysectomy than those in whom the disease had remained localized (Edelstyn et al, 1958), and (2) that the best results were obtained in patients with bony metastases, in those aged 41 to 50 years, and in those who had their operations performed early (McCalister, 1960).…”

Section: Resultsmentioning

confidence: 89%

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Factors Influencing Response to Hypophysectomy for Advanced Cancer of Breast

McCalister¹,

Welbourn²,

Edelstyn³

et al. 1961

BMJ

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Section: Resultsmentioning

confidence: 89%

“…In 54 the pituitary fossa was packed with yttrium-90 oxide after the gland had been removed (Edelstyn et al, 1958).…”

Section: Material Methods Definition Of Terms and Generalmentioning

confidence: 99%

Factors Influencing Response to Hypophysectomy for Advanced Cancer of Breast

McCalister¹,

Welbourn²,

Edelstyn³

et al. 1961

BMJ

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“…As practised in Belfast, this combines surgical removal of the pituitary with intrasellar radiation, using yttrium 90 in wax (Edelstyn et al, 1958) and has a mortality of 11% and an objective remission rate of 58 % with a mean duration of 20 months. The comparable figures from thiotepa were 11 %, 41%, and 7.5 months.…”

Section: Discussionmentioning

confidence: 99%

Thiotepa in Treatment of Advanced Breast Cancer

Lyons¹,

Edelstyn²

1962

BMJ

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“…The therapeutic procedures were (a) hypophysectomy performed by combined transfrontal removal of the pituitary with insertion of a plug of 90Y, a procedure developed to destroy residual fragments of gland (Edelstyn et al, 1958); (b) NEA administered orally, 10 mg 4 times daily (Edelstyn, 1973); (c) CCC regimen given as follows: Endoxana, 500 mg i.v. on Days 1 and 7, vincristine 0 75 mg i.v., 5-fluorouracil 500 mg i.v., methotrexate 2-5 mg b.d.…”

Section: Methodsmentioning

confidence: 99%

“…By June 1, 1973, 400 patients had been admitted to the programme, the breast cancer group numbering 81; these latter are reported in this paper. For comparison, and especially to show the relationship between response to treatment and individual characteristics of the neoplasm, studies by the first author with hypophysectomy and norethisterone acetate (NEA) (SH 420, Schering Chemicals) are quoted (Edelstyn et al, 1958;Edelstyn, Gleadhill and Lyons, 1968;Edelstyn, 1973). As the criteria for patient inclusion and assessment were identical and carried out in the same unit, we believe this comparison to be of value.…”

mentioning

confidence: 99%