Hypophyso-Gonadal Function in Humans during the First Year of Life

Forest, Maguelone G.; Sizonenko, Pierre C.; Cathiard, Anne-Marie; Bertrand, J

doi:10.1172/jci107621

Cited by 402 publications

(198 citation statements)

References 24 publications

Supporting

Mentioning

173

Contrasting

Unclassified

Order By: Relevance

“…11,13,14 The sex difference seen in the present study might be caused by the different growth patterns of girls and boys, 25 which could reflect the anabolic effects of early infancy sex hormone production in males 26,27 or could be due to endocrinologic differences.…”

Section: Discussionmentioning

confidence: 69%

Relationship between growth and feeding in infancy and body mass index at the age of 6 years

Gunnarsdóttir

Þórsdóttir

2003

Int J Obes

View full text Add to dashboard Cite

OBJECTIVE: To assess the relationship between size and growth measurements in infancy to body mass index (BMI) at 6 y. DESIGN: A longitudinal observation study on randomly chosen infants' growth and consumption in infancy. Follow-up until the age of 6 y. SUBJECTS: A total of 90 children who were born healthy and full-term. MEASUREMENTS: Weight and height were measured at maternity wards and healthcare centers in Iceland throughout infancy and at 6 y. Food records were made every month during infancy. At 2, 4, 6, 9 and 12 months, food was weighed to calculate food and nutrient intake. RESULTS: Weight gain from birth to 12 months as a ratio of birth weight was positively related to BMI at the age of 6 y in both genders (B ¼ 2.971.0, P ¼ 0.008, and B ¼ 2.070.9, P ¼ 0.032 for boys and girls, respectively). Boys in the highest quartile of protein intake (E%) at the age of 9-12 months had significantly higher BMI (17.872.4 kg/m 2 ) at 6 y than the lowest (15.671.0 kg/m 2 , P ¼ 0.039) and the second lowest (15.370.8 kg/m 2 , P ¼ 0.01) quartile. Energy intake was not different between groups. Together, weight gain at 0-12 months and protein intake at 9-12 months explained 50% of the variance in BMI among 6-y-old boys. CONCLUSION: Rapid growth during the first year of life is associated with increased BMI at the age of 6 y in both genders. In boys, high intake of protein in infancy could also contribute to childhood obesity.

show abstract

Section: Discussionmentioning

confidence: 69%

Relationship between growth and feeding in infancy and body mass index at the age of 6 years

Gunnarsdóttir

Þórsdóttir

2003

Int J Obes

View full text Add to dashboard Cite

show abstract

“…In this study only two patients; one of each group had their testis located in the abdomen, therefore the study is comparable also with regard to testicular position found at surgery. In male gonadotropin secretion which increases from 2 to 4 months after birth stimulating Leydig cells to secrete testosterone (12)(13)(14). Testosterone increase is blunted in cryptorchid boys (13,14).…”

Section: Commentsmentioning

confidence: 99%

Successful treatment of unilateral cryptorchid boys risking infertility with LH-RH analogue

Hadžiselimović¹

2008

Int. braz j urol.

View full text Add to dashboard Cite

Introduction: Infertility is the primary concern for boys with uni-or bilateral undescended testes. An early and seemingly successful orchiopexy does not improve fertility in a substantial number of cryptorchid males. We confirmed that LH-RH analogue (LH-RHa) treatment induces an increase in and maturation of the germ cells; however, it was uncertain if treatment would improve the chance of fertility later in life. Materials and Methods: Thirty unilateral cryptorchid boys, with an average age of 3 years at the time of surgery, were included in the study. Testicular biopsy showed that they had impaired testicular maturation and were therefore at high risk for infertility. Fifteen of the 30 unilateral cryptorchid boys were treated with 10 µg LH-RHa (Buserelin) nasal spray, administered on alternate days for a period of 6 months, following orchiopexy. The control group consisted of 15 cryptorchid boys who had been treated by Schoemakers type of orchiopexy, alone. After puberty, the ejaculates of both groups were analyzed. Results: All males in the untreated group were severely oligospermic, with 20% being azoospermic. In contrast, 86% of the treated ex-cryptorchid males had a sperm concentration within the normal range; this was significantly different from the sperm concentration found in the untreated group (p = 0.000008). Conclusion: For the first time, we demonstrate that infertility in cryptorchidism can be successfully corrected when suitably treated with a LH-RHa. Sperm parameters normalized following therapy in the majority of cryptorchid males who, untreated, would have remained infertile. This innovative hormonal treatment will have a profound effect on the current recommended surgical treatment of boys with undescended testes.

show abstract

“…By the end of the first trimester of fetal life, the gonadotrophin-releasing hormone (GnRH) pulse generator in the hypothalamus has developed and is functional [15][16][17][18][19]. Its activity will continue until about 6 months after birth in boys and 12-24 months in girls.…”

Section: Fetal and Early Neonatal Periodmentioning

confidence: 99%

Reproductive ageing in women

Djahanbakhch

Ezzati

Zosmer

2007

The Journal of Pathology

View full text Add to dashboard Cite

The traditional view in respect to female reproduction is that the number of oocytes at birth is fixed and continuously declines towards the point when no more oocytes are available after menopause. In this review we briefly discuss the embryonic development of female germ cells and ovarian follicles. The ontogeny of the hypothalamic-pituitary-gonadal axis is then discussed, with a focus on pubertal transition and normal ovulatory menstrual cycles during female adult life. Biochemical markers of menopausal transition are briefly examined. We also examine the effects of age on female fertility, the contribution of chromosomal abnormalities of the oocyte to the observed decline in female fertility with age and the possible biological basis for the occurrence of such abnormalities. Finally, we consider the effects of maternal age on obstetric complications and perinatal outcome. New data that have the potential to revolutionize our understanding of mammalian oogenesis and follicular formation, and of the female reproductive ageing process, are also briefly considered.

show abstract

Hypophyso-Gonadal Function in Humans during the First Year of Life

Cited by 402 publications

References 24 publications

Relationship between growth and feeding in infancy and body mass index at the age of 6 years

Relationship between growth and feeding in infancy and body mass index at the age of 6 years

Successful treatment of unilateral cryptorchid boys risking infertility with LH-RH analogue

Reproductive ageing in women

Contact Info

Product

Resources

About