Hypopigmented mycosis fungoides: a retrospective clinicohistopathologic study

Rodney, Ife J.; Kindred, Chesahna; Angra, Kunal; Qutub, Omar N.; Villanueva, A.R.; Halder, Rebat M.

doi:10.1111/jdv.13843

Cited by 48 publications

(73 citation statements)

References 27 publications

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“…Khopkar et al ., in a study involving 15 patients with hMF, demonstrated an average latency time between onset of the picture to final diagnosis of 3.83 years . In the study by Rodney et al ., that timeframe was closer to the one of this study: 5.3 years …”

Section: Discussionsupporting

confidence: 72%

“…In the study by Alsaleh et al ., the average age was 27.6 years . In 2017, Rodney and his colleagues, in a retrospective series of 20 cases, the age ranged from 4 to 57 years, with an average of 37.5 years . The present study found an average age, despite closer to the Rodney et al .…”

Section: Discussionsupporting

confidence: 62%

“…Regarding gender, different than the classic MF that mainly affects men, hMF does not seem to have such preference …”

Section: Discussionmentioning

confidence: 73%

“…Phototherapy, both PUVA and NB‐UVB, is an excellent option for hMF treatment, with a relatively fast response and remission of lesions as early as in the first two months, with response rates reaching up to 90% in several studies…”

Section: Discussionmentioning

confidence: 99%

“…The disease does not seem to have a preference regarding gender. The clinical course is painless, and progression of the disease is rare …”

Section: Introductionmentioning

confidence: 99%

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Hypopigmented mycosis fungoides: a 20‐case retrospective series

et al. 2018

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The clinical and epidemiological profile of patients with hypopigmented MF found in our sample is in agreement with what is described in the literature, with the exception of the age at diagnosis, higher than expected. Diagnostic delay time, despite long, is also consistent with the medical literature; however, in this sample, we had two cases of disease progression, with death of one patient, despite the treatment, which is extremely important since hypopigmented MF is usually associated with good prognosis.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 62%

“…Regarding gender, different than the classic MF that mainly affects men, hMF does not seem to have such preference …”

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

“…The disease does not seem to have a preference regarding gender. The clinical course is painless, and progression of the disease is rare …”

Section: Introductionmentioning

confidence: 99%

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Hypopigmented mycosis fungoides: a 20‐case retrospective series

et al. 2018

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Mycosis Fungoides in Children and Adolescents

et al. 2021

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IMPORTANCE Comprehensive data on childhood mycosis fungoides (MF) is scarce. OBJECTIVE To describe clinical features, immunophenotypes, various treatment options, and prognosis of MF in children and adolescents. EVIDENCE REVIEW This systematic review searched MEDLINE via PubMed, Embase, Cochrane, and Scopus databases in October 2019. The search terms included mycosis fungoides, infant, children, and adolescent.No filter for the publication period was used, but studies written in a language other than English were excluded. Reference lists of the relevant articles were also searched manually. Case series and case reports were included if data on childhood MF were extractable. The Asan Medical Center database for cases of childhood MF was also searched. Patients were treated from January 1, 1990, to July 31, 2019, and were younger than 20 years at the time of diagnosis. The methodologic quality of the included studies was assessed with items from the Newcastle-Ottawa scale. Data were analyzed from December 9, 2019, to September 4, 2020.FINDINGS A total of 571 unique patients were included. The mean (SD) age at diagnosis was 12.2 (4.2) years; at onset, 8.6 (4.2) years. The female-to-male ratio was 1:1.6 (350 male patients [61.3%]). Among 522 patients with data available at diagnosis, stage 1 disease constituted 478 cases (91.6%), followed by stage 2 (39 [7.5%]) and stage 4 (5 [1.0%]). Among the 567 patients with data available, the most common variant of MF was the hypopigmented form (309 [54.5%]), followed by classic MF (187 [33.0%]). The MF lesions were predominantly the CD4 + and CD8 + immunophenotype in 99 (49.5%) and 79 (39.5%) of 200 patients, respectively. Among the treatments, narrowband UV-B was the most frequently used (150 of 426 [35.2%]). Most patients were alive with the disease (185 of 279 [66.3%]); 83 of 279 (29.8%) were in complete remission; and 11 of 279 (3.9%) had died by the last follow-up. A longer time from onset to diagnosis (hazard ratio [HR], 1.24; 95% CI, 1.06-1.45), granulomatous slack skin (HR, 12.25; 95% CI,, granulomatous MF (HR, 14.59; 95% CI, 1.31-162.00), a history of organ transplant (HR, 10.15; 95% CI, 0.98-105.37), and stage 2 disease at the time of diagnosis (HR, 10.22; 95% CI, 2.94-35.50) were associated with worse outcomes. CONCLUSIONS AND RELEVANCEThe findings of this review suggest that there is often a significant delay until the establishment of a correct diagnosis of childhood MF, which may be detrimental to the prognosis.

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