Hypoprothrombinaemic bleeding in infants associated with diarrhea and antibiotics. Report of two cases.

Matsaniotis, N; Messaritakis, J.; Vlachou, Christina

doi:10.1136/adc.45.242.586

Archives of Disease in Childhood

1970

DOI: 10.1136/adc.45.242.586

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Hypoprothrombinaemic bleeding in infants associated with diarrhea and antibiotics. Report of two cases.

N Matsaniotis¹,

J. Messaritakis²,

Christina Vlachou³

Abstract: Short Reports due to biliary obstruction from enlarged portal glands. Confirmation of the diagnos:s during life has been made by histological examination of material from an infected mastoid, a cervical lymph node, or tibial bone-marrow (Amick, Alden, and Sweet, 1950). To the best of our knowledge, our patient is the first case of congenital tuberculosis diagnosed by liver biopsy. Summary A case of congenital tuberculosis presented with hepatosplenomegaly during the first month of life is reported. Diagnosis w… Show more

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Vitamin K deficiency in diarrhoea

Kumar

Marwaha

et al. 2001

Indian J Pediatr

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The study was undertaken to determine the frequency of occurrence of vitamin K deficiency in infants with diarrhoeal illness. Infants were categorized into four groups as follows: A(acute diarrhoea), B(protracted diarrhoea) C(intractable diarrhoea) and D(healthy controls). Screening coagulation tests, PT and PTTK along with estimation of functional activity and total antigenic levels of prothrombin were performed. The ratio of functional to total prothrombin was calculated. PT was prolonged in 30% (24/75) of all infants with diarrhoea as compared to controls where the abnormality was observed in 11.1% infants (2/18). The ratio of functional to total prothrombin was significantly lower in infants with diarrhoea, the mean +/- SD values being 0.65 +/- 0.41 vs 1.1 +/- 0.26. This difference was statistically highly significant (p < 0.001). Low ratio was observed in 57.3% (43/75) infants with diarrhoea. Thus functional to total prothrombin ratio identified approximately twice as many diarrhoeal infants with vitamin K deficiency as compared to PT alone. There was no significant correlation with breast feeding as the only mode of diet, or the prior administration of antibiotics in infants with diarrhoea. The inherent malabsorptive state in diarrhoea may be a major contributory factor.

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Vitamin K deficiency in diarrhoea

Kumar

Marwaha

et al. 2001

Indian J Pediatr

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Antibiotic-Associated Hypoprothrombinemia: A Review of Prospective Studies, 1966–1988

Shevchuk

Conly

1990

Clinical Infectious Diseases

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Inhibition of Vitamin K-Dependent Carboxylase in Vitro by Cefamandole and Its Structural Analogs

Uotila

Suttie

1983

Journal of Infectious Diseases

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Clinical use of the beta-lactam cephalosporins has resulted in a number of reports of vitamin K-responsive bleeding abnormalities. The effects of these antibiotics on the activities of vitamin K-dependent enzymes in vitro were therefore assessed. The activity of vitamin K-dependent carboxylase was inhibited by 50% by 6-10 mM cefamandole or structurally analogous cephalosporins. The inhibition was noncompetitive with respect to the pentapeptide substrate, vitamin KH2, and CO2. Vitamin K epoxide reductase was less sensitive to and only partially inhibited by cefamandole and the analogs. The possible physiologic significance of the inhibition of these enzymes in clinical hemorrhagic problems was considered.

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Hypoprothrombinaemic bleeding in infants associated with diarrhea and antibiotics. Report of two cases.

Cited by 3 publications

References 5 publications

Vitamin K deficiency in diarrhoea

Vitamin K deficiency in diarrhoea

Antibiotic-Associated Hypoprothrombinemia: A Review of Prospective Studies, 1966–1988

Inhibition of Vitamin K-Dependent Carboxylase in Vitro by Cefamandole and Its Structural Analogs

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