Hypospadias in six dogs

Jurka, P.; Galanty, M.; Zielińska, Paulina; Max, A.; Sysa, P.

doi:10.1136/vr.164.11.331

Cited by 17 publications

(17 citation statements)

References 5 publications

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“…Unfortunately, the intersexual dogs were not precisely described in terms of external genitalia, as well as gonad development. A detailed description of 6 dogs with hypospadias was reported by Jurka et al [2009]. This disorder was diagnosed in 6 males and 1 intersexual dog (78,XY).…”

Section: Discussionmentioning

confidence: 99%

“…It is generally assumed that it is rarely diagnosed in dogs, since in a review of over 2 million dogs presented in veterinary clinics in USA only 66 cases were diagnosed as hypospadic dogs [Hayes and Wilson, 1986]. On the other hand, it cannot be excluded that this disorder is not so rare, since in a single veterinary clinic 6 cases were diagnosed within a 5-year period [Jurka et al, 2009].…”

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confidence: 99%

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Hypospadias in a Male (78,XY; SRY-Positive) Dog and Sex Reversal Female (78,XX; SRY-Negative) Dogs: Clinical, Histological and Genetic Studies

Świtoński

Payan-Carreira

Bartz

et al. 2011

Sex Dev

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Hypospadias is rarely reported in dogs. In this study we pre-sent 2 novel cases of this disorder of sexual development and, in addition, a case of hereditary sex reversal in a female with an enlarged clitoris. The first case was a male Moscow watchdog with a normal karyotype (78,XY) and the presence of the SRY gene. In this dog, perineal hypospadias, bilateral inguinal cryptorchidism and testes were observed. The second case, representing the Cocker spaniel breed, had a small penis with a hypospadic orifice of the urethra, bilateral cryptorchidism, testis and a rudimentary gonad inside an ovarian bursa, a normal female karyotype (78,XX) and a lack of the SRY gene. This animal was classified as a compound sex reversal (78,XX, SRY-negative) with the hypospadias syndrome. The third case was a Cocker spaniel female with an enlarged clitoris and internally located ovotestes. Cytogenetic and molecular analyses revealed a normal female karyotype (78,XX) and a lack of the SRY gene, while histology of the gonads showed an ovotesticular structure. This case was classified as a typical hereditary sex reversal syndrome (78,XX, SRY-negative). Molecular studies were focused on coding sequences of the SRY gene (case 1) and 2 candidates for monogenic hypospadias, namely MAMLD1 (mastermind-like domain containing 1) and SRD5A2 (steroid-5-alpha-reductase, alpha polypeptide 2). Sequencing of the entire SRY gene, including 5′- and 3′-flanking regions, did not reveal any mutation. The entire coding sequence of MAMLD1 and SRD5A2 was analyzed in all the intersexes, as well as in 4 phenotypically normal control dogs (3 females and 1 male). In MAMLD1 2 SNPs, including 1 missense substitution in exon 1 (c.128A>G, Asp43Ser), were identified, whereas in SRD5A2 7 polymorphisms, including 1 missense SNP (c.358G>A, Ala120Thr), were found. None of the identified polymorphisms cosegregated with the intersexual phenotype, thus, we cannot confirm that hypospadias may be associated with polymorphism in the coding sequence of the studied genes.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Hypospadias in a Male (78,XY; SRY-Positive) Dog and Sex Reversal Female (78,XX; SRY-Negative) Dogs: Clinical, Histological and Genetic Studies

Świtoński

Payan-Carreira

Bartz

et al. 2011

Sex Dev

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“…The first was a 78,XY mixed breed [reviewed in Chaffaux and Cribiu, 1991] and the second a 78,XY Yorkshire terrier [Jurka et al, 2009]. The first had ambiguous genitalia, including an enlarged clitoris with a bone.…”

Section: Disorders Of Testicular Developmentmentioning

confidence: 99%

Gonadal and Sex Differentiation Abnormalities of Dogs and Cats

Meyers-Wallen¹

2011

Sex Dev

100

105

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The molecular steps in normal sexual development were largely discovered by studying patients and animal models with disorders of sexual development (DSD). Although several types of DSD have been reported in the cat and dog, which are often strikingly similar to human DSD, these have been infrequently utilized to contribute to our knowledge of mammalian sexual development. Canine and feline cases of DSD with sufficient evidence to be considered as potential models are summarized in this report. The consensus DSD terminology, and reference to previous terminology, is used to foster adoption of a common nomenclature that will facilitate communication and collaboration between veterinarians, physicians, and researchers. To efficiently utilize these unique resources as molecular tools continue to improve, it will be helpful to deposit samples from valuable cases into repositories where they are available to contribute to our understanding of sexual development, and thus improve human and animal health.

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“…The authors presumed one cause for the increasing incidence of hypospadias may be environmental pollution, which causes animals to be exposed constantly to oestrogenic compounds, resulting in reproductive problems. In lambs, most animals with hypospadias also have atresia ani, and the co-existence of these two abnormalities has been considered to be due to the origination of both in the urogenital and anal folds from the common cloaca in the hindgut developmental stage (Jurka et al 2009). In female dogs, recto-vaginal fistulas are commonly present in association with atresia ani Type 2 abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…This abnormality occurs more frequently in males, but can also occur in females (Hardy and Kustritz 2005). In dogs, there are five forms of hypospadias, which are classified depending on the location of the urethral opening, as glandular, penile, scrotal, perineal and anal forms (Jurka et al 2009). In most cases, the aetiology of hypospadias remains unclear, but generally, it is considered to be a congenital deformity that may be caused by inborn factors resulting in defects in androgen metabolism (Uda et al 2004).…”

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confidence: 99%

A rare case of a complex of multiple congenital anomalies diagnosed using computed tomography in a male puppy

Bae¹,

Chung²,

Chung³

et al. 2018

Vet. Med. - Czech

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ABSTRACT:A 50-day-old male Maltese puppy was presented with difficulty in defaecation. Based on the clinical signs, and physical and radiographic examinations, including computed tomography, his condition was diagnosed as hypospadias, along with atresia ani and urethrorectal fistula. Hypospadias is a congenital malformation of the urethra that is relatively uncommon in dogs, while atresia ani is a rare congenital anomaly of the rectum and anus. An additional anatomic abnormality that can be associated with atresia ani is a fistula between the urogenital tract and rectum. After appropriate surgical procedures, the puppy recovered and defaecation via the anus was restored.

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Hypospadias in six dogs

Cited by 17 publications

References 5 publications

Hypospadias in a Male (78,XY; <i>SRY</i>-Positive) Dog and Sex Reversal Female (78,XX; <i>SRY</i>-Negative) Dogs: Clinical, Histological and Genetic Studies

Hypospadias in a Male (78,XY; <i>SRY</i>-Positive) Dog and Sex Reversal Female (78,XX; <i>SRY</i>-Negative) Dogs: Clinical, Histological and Genetic Studies

Gonadal and Sex Differentiation Abnormalities of Dogs and Cats

A rare case of a complex of multiple congenital anomalies diagnosed using computed tomography in a male puppy

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