Hypotensive Activity of &lt;i&gt;Moringa oleifera&lt;/i&gt; Lam (Moringaceae) Root Extracts and its Volatile Constituents

Sana, Aisha; Saleem, Rubeena; Faizi, Shaheen

doi:10.4314/tjpr.v14i5.12

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…Docosenoic acid (Behenic acid) is used in the cosmetic industry as a hair conditioner or moisturizer (Warra, 2014). Earlier studies on the root revealed the presence of compounds such asmethylhexadecanoate, methyl 14-hydroxy-5tetradecenoate, 1, 11 diphenyl undecane and cyclopentanyl hexadecane, with the extracts showing hypotensive activity in rats (Sana et al, 2015;Faizi et al, 2014). This study also revealed the presence of like compounds.…”

Section: Tlc Analysissupporting

confidence: 57%

Study on Thin layer Chromatograghy (TLC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of methanolic extract of Moringa oleifera root

Madziga¹,

Usman²,

Mamza³

et al. 2021

Asian J Pharm Pharmacol

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Section: Tlc Analysissupporting

confidence: 57%

Study on Thin layer Chromatograghy (TLC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of methanolic extract of Moringa oleifera root

Madziga¹,

Usman²,

Mamza³

et al. 2021

Asian J Pharm Pharmacol

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“…Moringa oleifera Lam. is an edible plant that recently became popular as a dietary supplement and herbal medicine for the management of several chronic diseases such as diabetes (Azad et al, 2017; Fombang & Saa, 2016a), inflammation (Galuppo et al, 2014), hypertension (Fombang, Bouba, & Ngaroua, 2016; Sana, Saleem, & Faizi, 2015), and neurological disorders (Hannan et al, 2014). Majority of its medicinal properties have been attributed to the presence of phenolic compounds particularly flavonoids that show strong antioxidant activity (AOA) (Gopalakrishnan, Doriya, & Kumar, 2016).…”

Section: Introductionmentioning

confidence: 99%

Optimising extraction of antioxidants from roasted Moringa oleifera Lam. leaves using response surface methodology

Fombang

Nobossé

Mbofung

et al. 2020

J Food Process Preserv

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Optimal conditions for alcoholic extraction of antioxidants from roasted leaves of Moringa oleifera Lam. were determined using response surface methodology and the phenolic profile of optimised extract determined by HPLC‐PDA. The experimental results adequately fitted the second‐order polynomial models as indicated by regression coefficient (.90–.95), lack‐of‐fit >.05, and absolute deviation .01–.04). Using multiple responses optimization and desirability function, the optimal conditions needed to maximize simultaneously antioxidant activity, phenolic content and extract yield were 65%–75% ethanol, 55–65°C and 40 min. The experimental values were not significantly different (p > .05) from those predicted, indicating the suitability of the models in the studied range. HPLC analysis of the extract revealed the presence of quercetin, isoquercetin, caffeic acid, and rutin. Rutin (45 mg/g), a flavonoid, was the major phenolic. The extract exhibited significant antioxidant potential IC50 2,2‐diphenyl‐2‐picryl hydrazyl 1.28 mg/L, ferric reducing antioxidant power 236 mg AAE/g, total phenolic content 176 mg GAE/g and could be used as nutraceuticals. Practical applications Moringa oleifera L. leaves were roasted to improve antioxidant function and optimum conditions for the preparation of extract with optimal antioxidant potential determined using the multiple response optimization procedure. The resulting extract was freeze‐dried and its phenolic profile characterized by HPLC‐PDA. The powdered extract has good antioxidant (radical scavenging and ferric reducing) potential and contained rutin as the major phenolic flavonoid followed by quercetin, isoquercetin caffeic acid, and vanillin. The extract has potential for use in nutraceutical formulations for the prevention and management of oxidative stress and chronic diseases (diabetes, cardiovascular diseases, cancer).

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“…GC-MS analysis showed the presence of hydrocarbons, fatty acid esters, thiorureides, steroids, and isothiocyanate in almost all extracts. These constituents may be responsible for hypotensive potential of MO root extracts ( Sana et al, 2015 ).…”

Section: Role Of Mo In Cardiovascular Diseasesmentioning

confidence: 99%

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

et al. 2022

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Cardiac damage and vascular dysfunction due to underlying diseases, such as hypertension and cardiac thrombosis, or side effects from certain drugs may lead to critical illness conditions and even death. The phytochemical compounds in natural products are being prospected to protect the heart and vascular system from further damage. Moringa genus is a subtropical tree native to Asia and Africa, which includes 13 species; Moringa oleifera Lam. (MO) is the most cultivated for its beneficial uses. MO is also known as the “miracle tree” because it has been used traditionally as a food source and medicine to treat various diseases such as anemia, diabetes, and infectious or cardiovascular diseases. The phytochemical compounds identified in MO with functional activities associated with cardiovascular diseases are N,α-L-rhamnopyranosyl vincosamide, isoquercetin, quercetin, quercetrin, and isothiocyanate. This study aims to investigate the potency of the phytochemical compounds in MO as a protective agent to cardiac damage and vascular dysfunction in the cardiovascular disease model. This is a scoping review by studying publications from the reputed database that assessed the functional activities of MO, which contribute to the improvement of cardiac and vascular dysfunctions. Studies show that the phytochemical compounds, for example, N,α-L-rhamnopyranosyl vincosamide and quercetin, have the molecular function of antioxidant, anti-inflammation, and anti-apoptosis. These lead to improving cardiac contractility and protecting cardiac structural integrity from damage. These compounds also act as natural vasorelaxants and endothelium protective agents. Most of the studies were conducted on in vivo studies; therefore, further studies should be applied in a clinical setting.

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Hypotensive Activity of <i>Moringa oleifera</i> Lam (Moringaceae) Root Extracts and its Volatile Constituents

Cited by 10 publications

References 16 publications

Study on Thin layer Chromatograghy (TLC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of methanolic extract of Moringa oleifera root

Study on Thin layer Chromatograghy (TLC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of methanolic extract of Moringa oleifera root

Optimising extraction of antioxidants from roasted Moringa oleifera Lam. leaves using response surface methodology

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

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