Hypotensive Effects of Carvacrol on the Blood Pressure of Normotensive Rats

Aydın, Yasemin; Kutlay, Özden; Ari, Senem; Duman, Seval; Uzuner, Kubi̇lay; Aydın, Süleyman

doi:10.1055/s-2007-990236

Cited by 55 publications

(49 citation statements)

References 20 publications

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“…In normotensive rats, carvacrol at a dose of 100 mg/kg (i.p.) reduced blood pressure and heart rate, and inhibited the hypertension induced by L-NAME (Aydin et al, 2007). However, in isolated rat aorta, although Aydin et al (2007) did not observe any significant effect of carvacrol, PeixotoNeves et al (2010) demonstrated that this monoterpene induced an endothelium-independent relaxation, possibly cholinergic/nitric oxide pathways (Johnson et al, 2009) and mediated by activation of transient receptor potential melastatin 8 (TRPM8) (Venkatachalam & Montell, 2007;Johnson et al, 2009).…”

Section: Carvacrolmentioning

confidence: 99%

“…Besides the activities described above, monoterpenes also produce significant effects on the cardiovascular system, promoting, among other actions, vasorelaxation, decreased heart rate, and hypotension (Peixoto-Neves et al, 2010;Bastos et al, 2010;Aydin et al, 2007;Magalhães et al, 2008). Thus, these monoterpenes can be useful as agents for prevention and/or treatment of cardiovascular diseases (CVD).…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular effects of monoterpenes: a review

Santos¹,

Moreira²,

Fraga³

et al. 2011

Rev. bras. farmacogn.

158

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Abstract:The monoterpenes are secondary metabolites of plants. They have various pharmacological properties including antifungal, antibacterial, antioxidant, anticancer, anti-spasmodic, hypotensive, and vasorelaxant. The purpose of this research was to review the cardiovascular effects of monoterpenes. The data in this resarch were collected using the Internet portals Pubmed, Scopus, and ISI Web of Knowledge between the years 1987 and 2010. In the study 33 monoterpenes were included, which were related to each of the thirteen individual words: artery, cardiovascular, heart, myocyte, vasorelaxant, vessel, hypotension, hypotensive, cardiomyocyte, ventricular, vasodilatory, aorta, and aortic. The research utilized 22 articles published mainly in the journals Phytomedicine, Fundamental Clinical Pharmacology, Planta Medica, Life Science, European Journal of Pharmacology, and Brazilian Journal of Medical and Biological Research. Of the 33 monoterpenes studied surveyed, sixteen of them had already been studied for their effects on the cardiovascular system: carvacrol, citronellol, p-cymene, eucalyptol (1,8-cineole), linalool, menthol, myrtenal, myrtenol, α-pinene, rotundifolone (piperitenone oxide), sobrerol, thymol, α-limonene, α-terpinen-4-ol, α-terpineol, and perillyl alcohol. The main effects observed were vasorelaxation, decreased heart rate and blood pressure. This review showed that the monoterpenes may be considered promising agents for prevention or treatment of diseases of the cardiovascular system.

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Section: Carvacrolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiovascular effects of monoterpenes: a review

Santos¹,

Moreira²,

Fraga³

et al. 2011

Rev. bras. farmacogn.

158

View full text Add to dashboard Cite

show abstract

“…T. schimperi contained important antifungal substances such as thymol, linalool, and carvacrol (Lakew, 2011). The pharmacological actions of the plant extracts were suggested to be parallel to their carvacrol contents (Aydin et al, 2007). Carvacrol is considered to be biocidal, resulting in bacterial membrane perturbations.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of Thymus schimperi Ronninger (Lamiaceae) against standard and clinical isolates of human pathogenic bacteria

Bayu¹,

Abera²,

Mebratu³

et al. 2015

J. Med. Plants Res.

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Thymus schimperi Ronninger (Lamiaceae) locally known as Tosign, is a multipurpose endemic plant that has been used for various remedies as constituents of traditional medicine in Ethiopia. The objective of this study is to evaluate antibacterial activity of water, ethanol, methanol and chloroform extracts of T. schimperi using agar well diffusion and broth dilution methods against human pathogenic bacterial strains. Amongst the solvents used for this study, chloroform extract possess the highest potential of inhibiting the growth of all bacteria under study at concentrations of 50 mg/ml while ethanol and methanol extract fail to inhibit three gram negative bacteria, namely: Escherichia coli (ATCC 25922), Klebsiella pneumoniae (clinical isolate) and Shigella flexneri (ATCC 12022) at the same concentration. Water extract did not show any zone of inhibition on all test bacteria as compared to other solvents. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were performed only for chloroform extracts that showed inhibition against all test organisms. This study revealed that, the highest inhibition with chloroform extract was exhibited against Methicillin-Resistant S. aureus (MRSA) with mean zones of inhibition of 22.6+2.5 mm whilst the minimum inhibition zone was observed for E. coli with mean zone of inhibition of 14.6+2.3 mm. The MIC value ranged from 6.25 to 12.5 mg/ml while the MBC value ranged from 6.25 mm to 25 mg/ml. This study clearly indicates that the crude chloroform extract of T. schimperi showed highest antibacterial activity against all studied bacterial strains as compared to the three solvents used in this study. Thus, further study and characterization of active compounds of chloroform extract of this plant is required.

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“…(Inamuco et al, 2012;Luz Ida et al, 2012;Moschonas et al, 2012), Escherichia coli (Obaidat and Frank, 2009) and others (Nostro and Papalia, 2012). Furthermore, carvacrol has anticancer (Koparal and Zeytinoglu, 2003;, anti-hyperlipidemic (Aristatile et al, 2009), anti-inflammatory (Fachini-Queiroz et al, 2012Lima et al, 2012), anti-ulcer , antinociceptive (Cavalcante Melo et al, 2012;Guimaraes et al, 2010), antidepressant-like (Melo et al, 2011a), hypotensive (Aydin et al, 2007) and vasorelaxant activities (PeixotoNeves et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Relaxant effect of carvacrol, citronellal and p-cymene, monoterpenes present in Thymus and Cymbopogon species, in guinea-pig trachea: A comparative study

Silva¹,

Silva²,

Sampaio³

et al. 2014

J. Med. Plants Res.

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Respiratory diseases are responsible for significant morbidity and mortality in worldwide. One of most important respiratory disease is asthma, which the current treatment is based on use of β 2 -agonists combined to inhaled corticosteroids. However, in recent years, many in vitro studies have attempted to validate the use of aromatic medicinal plants and its chemical compounds, such as monoterpenes, as potential therapeutically alternatives. In this work it was demonstrated that three different monoterpenes (carvacrol, citronellal and p-cymene) has relaxant effect in guinea-pig trachea, somehow showing different profile regarding epithelium presence, potency and efficacy.

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Hypotensive Effects of Carvacrol on the Blood Pressure of Normotensive Rats

Cited by 55 publications

References 20 publications

Cardiovascular effects of monoterpenes: a review

Cardiovascular effects of monoterpenes: a review

Antimicrobial activity of Thymus schimperi Ronninger (Lamiaceae) against standard and clinical isolates of human pathogenic bacteria

Relaxant effect of carvacrol, citronellal and p-cymene, monoterpenes present in Thymus and Cymbopogon species, in guinea-pig trachea: A comparative study

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