Hypotensive Effects of Xipamide in Essential Hypertension. Crossover Comparison With Hydrochlorothiazide

Abstract

Twenty-nine patients with mild to severe essential hypertension were treated with titrated doses of xipamide, before or after treatment with 50 and , if necessary, 100 mg hydrochlorothiazide in a 13- to 25-week open crossover study. Based on supine diastolic pressure readings taken at weekly intervals, xipamide controlled hypertension in all subjects: 17 achieved control with a daily dose of 5 mg; seven, with 10 mg; and five, with 20 mg. In contrast, eight of the 29 patients could not be controlled with 100 mg/day hydrochlorothiazide. The only significant biochemical change observed was an increase in serum uric acid in 12 patients after hydrochlorothiazide but in only six patients after xipamide. Natriuresis was comparable after both drugs; 5 and 10 mg xipamide were as effective as 50 and 100 mg hydrochlorothiazide. The only side effect noted, cramping due to hypokalemia, occurred during treatment with hydrochlorothiazide, but not xipamide, and was reversed by potassium supplements.

Xipamide

“…Comparable antihypertensive effects have been demonstrated for 40-80 mg xipamide and 5 mg bendrofluazide, 40 mg xipamide and 100 mg chlorthalidone, 40 mg xipamide and 50 mg hydrochlorothiazide, 20 mg xipamide and 50 mg chlorthalidone, 10-20 mg xipamide and 0.5 mg cyclopenthiazide, and 20 mg xipamide and 2.5 mg indapamide (32,42,43,47,61,62). Xipamide at 9 mg was more effective in lowering arterial pressure than 69 mg of hydrochlorothiazide (39). It can be concluded that as an antihypertensive agent xipamide is at least as potent as other diuretics.…”

Ксипамид: От Фармакологических Свойств К Клиническому Применению

“…В исследовании, проведённом R. Pasquel и соавт. [36], у 29 больных с АГ изучена антигипертензивная эффективность ксипамида в титруемых дозах до и после лечения гидрохлоротиазидом в дозе 50 мг/сут и при необходимости 100 мг/сут в открытом перекрёстном исследовании длительностью от 13 до 25 нед. По данным еженедельных измерений, у всех больных, получавших ксипамид, удавалось контролировать уровень АД Д : у 17 на фоне суточной дозы 5 мг, у 7 -10 мг и у 5 -20 мг.…”