Hypothalamic–pituitary–adrenal axis functioning in remitted, manic and depressed bipolar patients compared to controls

Giurgiuca, Ana; Matei, Vasilica; Crasan, A.; Grigoraș, R.; Cozman, Doina; Schipor, Sorina; Caragheorgheopol, Andra; Postolache, E; Roşca, Adrian Eugen

doi:10.1016/j.euroneuro.2018.11.1064

Cited by 1 publication

(2 citation statements)

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“…Overall, blood pathways mainly belonged to the immune-inflammatory imbalance and kynurenine pathway, while brain tissue pathways were enriched in the hypothalamic-pituitary-adrenal axis (HPA), circular rhythm abnormalities, mitochondrial dysfunction and oxidative stress, and changes in neuroplasticity and neurotrophic signaling. These ideas are conforming to the accepted hypothesis that falls within mood disorders ( 29 – 31 ).…”

Section: Resultssupporting

confidence: 84%

“…Wnt signaling is triggered in cell autonomously by time-dependent expression of WNT5A and activation of non-canonical signaling ( 59 – 61 ). ADCY2 is involved in cortisol synthesis, and elevated cortisol levels affect HPA axis activity ( 30 , 31 , 62 ). Therefore, tissue-specific genes may affect the pathogenesis and pathophysiology of MDD and BP.…”

Section: Discussionmentioning

confidence: 99%

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Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder

et al. 2022

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Tissue-specific gene expression has been found to be associated with multiple complex diseases including cancer, metabolic disease, aging, etc. However, few studies of brain-tissue-specific gene expression patterns have been reported, especially in psychiatric disorders. In this study, we performed joint analysis on large-scale transcriptome multi-tissue data to investigate tissue-specific expression patterns in major depressive disorder (MDD) and bipolar disorder (BP). We established the strategies of identifying tissues-specific modules, annotated pathways for elucidating biological functions of tissues, and tissue-specific genes based on weighted gene co-expression network analysis (WGCNA) and robust rank aggregation (RRA) with transcriptional profiling data from different human tissues and genome wide association study (GWAS) data, which have been expanded into overlapping tissue-specific modules and genes sharing with MDD and BP. Nine tissue-specific modules were identified and distributed across the four tissues in the MDD and six modules in the BP. In general, the annotated biological functions of differentially expressed genes (DEGs) in blood were mainly involved in MDD and BP progression through immune response, while those in the brain were in neuron and neuroendocrine response. Tissue-specific genes of the prefrontal cortex (PFC) in MDD-, such as IGFBP2 and HTR1A, were involved in disease-related functions, such as response to glucocorticoid, taste transduction, and tissue-specific genes of PFC in BP-, such as CHRM5 and LTB4R2, were involved in neuroactive ligand-receptor interaction. We also found PFC tissue-specific genes including SST and CRHBP were shared in MDD-BP, SST was enriched in neuroactive ligand-receptor interaction, and CRHBP shown was related to the regulation of hormone secretion and hormone transport.

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Section: Resultssupporting

confidence: 84%