Hypothalamic thermo‐responsive neurones in the new‐born rat.

Hori, Tetsuro; Shinohara, Koichi

doi:10.1113/jphysiol.1979.sp012945

Cited by 42 publications

(11 citation statements)

References 27 publications

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“…Postnatal development of thermosensitivity in POAH neurons was observed both in vitro [23] and in vivo [22]. In mice, cell bodies of POAH warm-sensitive neurons in which granules were diffusely distributed were ovoid in shape and about 10-17 um in diameter.…”

Section: Thermosensitivities Of Brain Tissuesmentioning

confidence: 99%

Thermosensitive neurons in the brain.

Nakayama

1985

Jpn.J.Physiol

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Experimental methods commonly used in brain research, such as transection, ablation, focal lesion, and stimulation of the higher nervous structures have disclosed not only hypothalamic control of body temperature but also temperature sensitivity of the hypothalamus per se. Several classical studies clearly demonstrated that local warming or cooling of the hypothalamus produced appropriate thermoregulatory responses. The existence of thermosensitive neurons in the preoptic and anterior hypothalamic area (POAH) was first reported in the early 1960s [44,45], paving the way for neurophysiological studies on thermoregulation.A neuron that increases its steady discharge frequency at higher or lower local temperature is called a warm-sensitive or cold-sensitive neuron, respectively. The former type is encountered more frequently during microelectrode exploration. POAH thermosensitive neurons have been found not only in mammals, but also in birds, reptiles, and fish. More recent studies have revealed a wide distribution of thermosensitive neurons in the nervous system, including the midbrain, medulla oblongata, and spinal cord.Almost all cell activities in living organisms are, of course, more or less temperature dependent. At least two tests are required to distinguish whether a particular thermosensitive neuron is involved in temperature regulation. One is whether thermal stimulation of the region containing the particular neuron evokes appropriate thermoregulatory responses. From this point of view, the midbrain is the only exception among the areas mentioned above. Another point to be examined is whether a particular neuron is specifically sensitive to local temperature. Various criteria have been proposed to classify neurons into thermosensitive and non-thermosensitive types. Neurons having thermosensitivity of at least 0.8 imp/sec °C are considered warm-sensitive and those with at least -0.6 are considered cold-sensitive [5]. Furthermore, in a brain with complex neural networks, deciding whether a neuron is a true thermoreceptor or a thermosensitive interneuron is difficult even if the neuron shows a relatively high Q1° value. These difficulties led investigators undertake in vitro studies on neuronal thermosensitivity that clearly demonstrated the presence of true thermally sensitive neurons

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Section: Thermosensitivities Of Brain Tissuesmentioning

confidence: 99%

Thermosensitive neurons in the brain.

Nakayama

1985

Jpn.J.Physiol

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“…Many authors of the early studies of the thermoregulatory effect of CAP thought that CAP-sensitive neurons in the POA play a thermosensory role (Szolcsá nyi et al, 1971;Hori and Shinohara, 1979;Dib, 1982), which would mean that warm-sensitive MPO neurons express TRPV1 channels and that these TRPV1 channels determine, at least in part, the neuronal sensitivity to local temperature. However, CAP does not seem to act on MPO neurons directly, because no electrophysiological evidence exists for the presence of postsynaptic CAP-sensitive receptors on these neurons (Karlsson et al, 2005).…”

Section: B the Preoptic Hypothalamusmentioning

confidence: 99%

“…Other pieces of evidence that are often cited to support the central mediation hypothesis are less convincing because they leave more room for alternative interpretations. For example, subcutaneous CAP was reported to excite warm-sensitive POA neurons (Nakayama et al, 1978;Hori and Shinohara, 1979;Hori, 1984), but such an excitation could have occurred secondarily to an action on any part of the afferent thermoeffector pathways (Fig. 1).…”

Section: B Thermoregulatory Effects Of Transient Receptormentioning

confidence: 99%

“…Long before this channel received its current name, TRPV1, it was suspected to play the roles of both a peripheral thermosensor (Dib, 1983;Donnerer and Lembeck, 1983;Obá l et al, 1987) and a central thermosensor (Szolcsá nyi et al, 1971;Hori and Shinohara, 1979;Dib, 1982) for autonomic and behavioral thermoregulation (i.e., to detect those thermal signals that are used in the control of autonomic and behavioral thermoeffectors). More recently, interest in the thermoregulatory role of TRPV1 has surged because of a serious problem with the development of TRPV1 antagonists, widely regarded as nextgeneration pain therapeutics.…”

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confidence: 99%

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The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

et al. 2009

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“…Extracellular single-unit activities were recorded with a glass microelectrode filled with Pontamine sky blue acetate (impedance, (Hori & Shinohara, 1979;Asami, Asami, Hori, Kiyohara & Nakashima, 1988). Subsequently, the activities of neurones were observed at a constant temperature (36-37 00) during perfusion of prostaglandin E2 (PGE2) (1-900 nm, Sigma) and a prostaglandin antagonist, AH6809, (0-3-30 IUM, kindly provided by Dr B. M. Bain, Glaxo Group Research Limited) with or without PGE2.…”

Section: Recordingmentioning

confidence: 99%

Thermal and PGE2 sensitivity of the organum vasculosum lamina terminalis region and preoptic area in rat brain slices.

Matsuda

Hori

Nakashima

1992

The Journal of Physiology

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SUMMARY1. The effects of local applications of prostaglandin E2 (PGE2) on the unit activity of fifty-one neurones in the organum vasculosum lamina terminalis (OVLT) region and fifty-eight neurones in the preoptic area (POA) were investigated in small tissue slices from the rat hypothalamus containing the OVLT and POA isolated from each other.2. Of these, thirty OVLT and twenty-eight POA neurones were warm sensitive and increased their discharge rate in response to a rise in tissue temperature. One OVLT neurone and one POA neurone were cold sensitive and showed the opposite type of responses to changes in temperature. The thermosensitivity of these neurones was still observed in a Ca21 free-high Mg2+ solution.3. Perfusion with PGE2 in doses between 1 and 250 nm changed the discharge rate in forty-two of fifty-one OVLT neurones and in thirty-two of fifty-eight POA neurones in a dose-dependent manner. The responses to PGE2 were not lost during synaptic blockade. The threshold dose of PGE2 to alter the discharge rate of the OVLT neurones (4-8+1-1 (S.E.M.) nM, n = 16) was significantly lower than that of the POA neurones (40 9 + 12 2 nm, n = 16).4. Fifteen of forty-two OVLT neurones exhibited the responses with a slower onset (latency 5-13 min) and a longer duration (20 min to 3 h), but such responses were observed in only one of thirty-two POA neurones.5. The responses of OVLT and POA neurones to PGE2 (50-250 nm) were reversibly blocked by a concurrent application of AH6809. a prostanoid EP, and/or a DP receptor antagonist.6. While there was no clear correlation between the type of thermosensitivity and the type of response to PGE2 among the POA neurones, a significantly higher incidence of inhibitory response to PGE2 was found among the warm-sensitive neurones in the OVLT region.7. The lower threshold responses to PGE2 and the higher incidence of PGE2 responsiveness among OVLT neurones are consistent with previous findings which showed that the highest density of PGE2 receptor binding and the highest pyrogenic sensitivity to microinjected PGE2 were observed in the OVLT region. The results MS 9526

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Hypothalamic thermo‐responsive neurones in the new‐born rat.

Cited by 42 publications

References 27 publications

Thermosensitive neurons in the brain.

Thermosensitive neurons in the brain.

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

Thermal and PGE2 sensitivity of the organum vasculosum lamina terminalis region and preoptic area in rat brain slices.

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