Hypothermia during kainic acid-induced seizures reduces hippocampal lesions and cerebral nitric oxide production in immature rabbits

Moderate body hypothermia alleviates behavioral and EEG manifestations of audiogenic seizures in metaphit-treated rats

“…On the other hand, our results do not support the findings that refer to the facilitating influence of hypothermia on seizures, as reported by some other authors (Ferrari and Amantea 1955;Ostojić et al 1995). The absence of significant changes in rat EEG from the hypothermic control group agrees with the results of other workers (Takei et al 2004).…”

Hypothermia for Refractory Status Epilepticus

“…It is particularly appealing both for its neuroprotective and its antiepileptic properties. Rats made hypothermic demonstrate ameliorated epileptic brain damage related to SE when compared to normothermic and hyperthermic groups [20,[23][24][25]. Cooling, particularly in conjunction with diazepam, diminished Fig.…”

“…Hypothermia reduces excitatory transmissions, decreases the global cerebral metabolic rate for glucose and oxygen, reduces ATP breakdown, and stimulates glycolysis by intracellular alkalinization enhancing energy production [19,26]. Its neuroprotective qualities may stem from this energy conservation and its attenuation of NO production [25].…”

Mild Hypothermia Prevents Post-Traumatic Hyperactivity of Excitatory Synapses in Rat Hippocampal CA1 Pyramidal Neurons

“…Melatonin, phenylbutylnitrone and edaravone, free radical scavengers, have protective effects against TBI via scavenging ROS and reactive nitrogen species (RNS) [29,[50][51][52]. It has been demonstrated that mild hypothermia (32-34°C) reduces post-traumatic neuronal disturbance by suppressing the production of superoxide and NMDA receptor-mediated nitric oxide (NO) production [53][54][55]. The mild hypothermia-induced neuroprotection may be due to reduced post-traumatic induction of ROS in the rat brain.…”