Hypothermia induced in mice by injection of venom sac extract of hornets (Vespa orientalis, Vespinae: Hymenoptera)

Ishay, Jacob S.; Shemesh, E; Lilling, I.

doi:10.1007/bf01960623

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…As for the occurrence of hypothermia we demonstrated in a previous study that one fraction in hornet venom, namely mastoparan, is responsible for inducing hypothermia in mammals (Duvdevani et al 1991). In earlier studies we reported the induction by hornet venom of hypothermia in albino (ICR) mice (Ishay et al 1983) as well as in cats (Barenholz-Paniry et al. 1990).…”

Section: Discussionmentioning

confidence: 98%

Cardiovascular Haemodynamics of Oriental Hornet Venom Sac Extract

Rubin

Duvdevani

Ishay

1993

Pharmacology & Toxicology

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The effects of hornet venom sac extract on the functioning of the cardiovascular system was assessed in dogs by concomitant examination of the following parameters: Systemic blood pressure, blood pressure and the dp/dt derivative of the left ventricle of the heart, heart rate, direct measurement of the left ventricular wall thickness, cardiac output, and body temperature. The effect of adult hornet venom sac extract on the canine cardiovascular system was rapid and led to a sharp drop in the systemic blood pressure, a similar drop in the pressure and dp/dt derivative in the left ventricle, to bradycardia, immediate thickening of the left ventricular wall and to an immediate rise in the cardiac output. As for the canine temperature, this dropped immediately following the administration of venom sac extract and remained at the new low level for at least 30 min. The smaller molecular weight components (less than 10 kilodalton) in venom sac extract have been found to be responsible for the immediate effects of venom sac extract on the cardiovascular system. On the other hand the high‐molecular weight components exert more delayed effects which lead to a cumulative disturbance of cardiac function.

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Section: Discussionmentioning

confidence: 98%

Cardiovascular Haemodynamics of Oriental Hornet Venom Sac Extract

Rubin

Duvdevani

Ishay

1993

Pharmacology & Toxicology

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Mastoparan induces hypothermia in mice

1991

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The polypeptide mastoparan, isolated from the venom of the Oriental Hornet, Vespa orientalis, induces hypothermia in white mice 15 minutes after its intraperitoneal injection. The hypothermic effect is induced by mastoparan obtained from different hornet and wasp venoms. The normal murine core temperature is lowered by mastoparan from 38 degrees C to as far as 33 degrees C. This lowering lasts for one hour and is reversible.

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