Hypothermic pulsatile perfusion of human pancreas: Preliminary technical feasibility study based on histology

Branchereau, J.; Renaudin, Karine; Kervella, Delphine; Bernadet, S.; Karam, Georges; Blancho, Gilles; Cantarovich, Diego

doi:10.1016/j.cryobiol.2018.10.002

Cited by 37 publications

(34 citation statements)

References 25 publications

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“…There are similar studies of hypothermic machine perfusion of the pancreases, that demonstrated reduced graft oedema and reduced islet and acinar damage (19,20). One study using 20 human pancreases in a hypothermic pulsatile perfusion of marginal human pancreas-duodenum organs for 24 h showed that this strategy was feasible with no deleterious parenchymal effect (21). Further observations highlighted that the ideal parameters for hypothermic continuous perfusion of pancreases has been difficult to ascertain.…”

Section: The Rationale Of Organ Preservation By Machine Perfusionmentioning

confidence: 96%

“…ATP is also a marker of the viability of machine-perfusion treated grafts (23). The Branchereau study highlighted that the tissuebiopsies of the pancreases in the HMP-group had a higher concentration of ATP levels when compared to the control group (21,24). The maintenance of low pulsatile perfusion pressures in turn prevents endothelial damage and increased vasculature thrombosis (24,25).…”

Section: The Rationale Of Organ Preservation By Machine Perfusionmentioning

confidence: 99%

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Organ Restoration With Normothermic Machine Perfusion and Immune Reaction

et al. 2020

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Section: The Rationale Of Organ Preservation By Machine Perfusionmentioning

confidence: 96%

Section: The Rationale Of Organ Preservation By Machine Perfusionmentioning

confidence: 99%

Organ Restoration With Normothermic Machine Perfusion and Immune Reaction

et al. 2020

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“…More recent studies in the human pancreas indicated that especially DCD pancreas benefits more from oxygenated HMP compared to SCS alone (91). Even 24 h of HMP of ECD human pancreas-duodenum organs was feasible resulting in no deleterious parenchymal effects (92). Since those studies focused on the results after MP without following Tx, currently, there are no data available about clinical outcomes in this context.…”

Section: Machine Perfusion Of Extended Criteria Donor Pancreas Graftsmentioning

confidence: 99%

Machine Perfusion of Extended Criteria Donor Organs: Immunological Aspects

et al. 2020

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Due to higher vulnerability and immunogenicity of extended criteria donor (ECD) organs used for organ transplantation (Tx), the discovery of new treatment strategies, involving tissue allorecognition pathways, is important. The implementation of machine perfusion (MP) led to improved estimation of the organ quality and introduced the possibility to achieve graft reconditioning prior to Tx. A significant number of experimental and clinical trials demonstrated increasing support for MP as a promising method of ECD organ preservation compared to classical static cold storage. MP reduced ischemia-reperfusion injury resulting in the protection from inadequate activation of innate immunity. However, there are no general agreements on MP protocols, and clinical application is limited. The objective of this comprehensive review is to summarize literature on immunological effects of MP of ECD organs based on experimental studies and clinical trials.

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“…Because of the large number of perfusion systems and preclinical and clinical trials, we exemplarily discuss the potential of machine perfusion in the setting of liver perfusion in the following section. Various reviews and reports on perfusion systems for the heart , lung , kidney , and initial studies in pancreas and VCA are available elsewhere.…”

Section: Advances In Organ and Tissue Preservationmentioning

confidence: 99%

Emerging technologies in organ preservation, tissue engineering and regenerative medicine: a blessing or curse for transplantation?

et al. 2019

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Summary Since the beginning of transplant medicine in the 1950s, advances in surgical technique and immunosuppressive therapy have created the success story of modern organ transplantation. However, today more than ever, we are facing a huge discrepancy between organ supply and demand, limiting the potential for transplantation to save and improve the lives of millions. To address the current limitations and shortcomings, a variety of emerging new technologies focusing on either maximizing the availability of organs or on generating new organs and organ sources hold great potential to eventully overcoming these hurdles. These advances are mainly in the field of regenerative medicine and tissue engineering. This review gives an overview of this emerging field and its multiple sub‐disciplines and highlights recent advances and existing limitations for widespread clinical application and potential impact on the future of transplantation.

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Hypothermic pulsatile perfusion of human pancreas: Preliminary technical feasibility study based on histology

Cited by 37 publications

References 25 publications

Organ Restoration With Normothermic Machine Perfusion and Immune Reaction

Organ Restoration With Normothermic Machine Perfusion and Immune Reaction

Machine Perfusion of Extended Criteria Donor Organs: Immunological Aspects

Emerging technologies in organ preservation, tissue engineering and regenerative medicine: a blessing or curse for transplantation?

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