2021
DOI: 10.1002/lary.29451
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Hypothyroidism in Head and Neck Squamous Cell Carcinoma Patients Receiving Radiotherapy With or Without Immune Checkpoint Inhibitors

Abstract: Objectives/Hypothesis Hypothyroidism is a relatively common complication of head and neck squamous cell carcinoma (HNSCC) treatment. The objective of this study was to determine whether the addition of programmed death ligand‐1 (PD‐1) or programmed death ligand‐1 (PD‐L1) inhibition (anti‐PD‐1/PD‐L1 therapy) to standard treatment increases the risk of hypothyroidism in HNSCC. Study Design Retrospective Cohort. Methods This is a retrospective, single institutional cohort study. Patients who received radiotherapy… Show more

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Cited by 4 publications
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“…Notably, systemic chemotherapy did not increase the incidence of HT in our study. More modern adjuvant immune checkpoint inhibitors were also not found to be related to higher incidence of HT [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Notably, systemic chemotherapy did not increase the incidence of HT in our study. More modern adjuvant immune checkpoint inhibitors were also not found to be related to higher incidence of HT [ 28 ].…”
Section: Discussionmentioning
confidence: 99%