Incidence of radiation-induced hypothyroidism following head and neck irradiation: a single-center analysis

Jia-Mahasap, Bongkot; Assavanopakun, Kasira; Chitapanarux, Imjai; Kittidachanan, Kittikun; Sirikul, Wachiranan

doi:10.5603/rpor.a2022.0055

Cited by 2 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lee et al analyzed 149 patients with NPC and showed that age has no significant effect upon RIHT [ 14 ]. Several researches also believed that age’s effect upon RIHT is not significant, which was consistent to our study [ 15 , 16 ]. However, in Diaz et al’s research, the risk for increasing age were 0.93 [ 17 ].…”

Section: Discussionsupporting

confidence: 92%

Analysis of correlative risk factors for radiation-induced hypothyroidism in head and neck tumors

Wang,

Hou,

Wang

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

Objective The aim of the study is to identify clinical and dosimetric factors that could predict the risk of radiation-induced hypothyroidism(RIHT) in head and neck cancer(HNC) patients following intensity-modulated radiotherapy(IMRT). Methods A total of 103 HNC patients were included in our study. General clinical characteristic and dosimetric data of all recruited patients were analyzed, respectively. The univariate and multivariate logistic regression anlalysis were successively conducted to identify optimal predictors, which aim to construct the nomogram. And the joint prediction was performed. Results The incidence of patients with HNC was 36.9% (38/103). Among the clinical factors, gender, N stage, chemotherapy, frequency of chemotherapy and surgery involving the thyroid were related to RIHT. Logistic regression analysis showed that thyroid volume, Dmean, VS45, VS50, VS60 and V30,60 were independent predictors of RIHT, which were also incorporated in the nomogram. An AUC of 0.937 (95%CI, 0.888–0.958) also was showed outstanding resolving ability of the nomogram. When the volume of the thyroid was greater than 10.6 cm3, the incidence of RIHT was 14.8%, and when the volume of the thyroid was equal to or smaller than 10.6 cm3, the incidence was 72.5%. The incidence rates of RIHT in the group with VS60≦8.4cm3 and VS60 > 8.4cm3 were 61.4% and 19.3%, respectively. Conclusions Thyroid volume and thyroid VS60 are independent predictors of RIHT in patients with HNC. Moreover, more attention should be paid to patients with thyroid volume ≤ 10.6cm3. Thyroid VS60 > 8.4cm3 may be a useful threshold for predicting the development of RIHT. The nomogram conducted by the research may become a potential and valuable tool that could individually predict the risk of RIHT for HNC patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Analysis of correlative risk factors for radiation-induced hypothyroidism in head and neck tumors

Wang,

Hou,

Wang

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…This study showed that 40.6% of patients developed hypothyroidism. The same study demonstrated that when the volume of the thyroid spared from radiation therapy was more than 5 cm 3 , the risk of hypothyroidism decreased [ 74 •].…”

Section: Thyroid Complications Of Radiation Fibrosis Syndromementioning

confidence: 99%

The Evaluation and Management of Visceral Complications in Radiation Fibrosis Syndrome Part 1

Jacob

Bade

Joffe

et al. 2023

Curr Phys Med Rehabil Rep

View full text Add to dashboard Cite

External beam ionizing radiation is a fundamental component of cancer treatment and is incorporated into approximately 50% of cancer treatments. Radiation therapy causes cell death directly by apoptosis and indirectly by disruption of mitosis. Purpose of Review This study aims to inform rehabilitation clinicians of the visceral toxicities of radiation fibrosis syndrome and how to detect and diagnose these complications. Recent Findings Latest research indicates that radiation toxicity is primarily related to radiation dose, patient co-morbidity, and concomitant use of chemotherapies and immunotherapies for the treatment of cancer. While cancer cells are the primary target, surrounding normal cells and tissues are also affected. Radiation toxicity is dose dependent, and tissue injury develops from inflammation that may progress to fibrosis. Thus, radiation dosing in cancer therapy is often limited by tissue toxicity. Although newer radiotherapeutic modalities aim to limit delivery of radiation to non-cancerous tissues, many patients continue to experience toxicity. Summary To ensure early recognition of radiation toxicity and fibrosis, it is imperative that all clinicians are aware of the predictors, signs, and symptoms of radiation fibrosis syndrome. Here, we present part 1 of the visceral complications of radiation fibrosis syndrome, addressing radiation-related toxicity in the heart, lungs, and thyroid gland. Graphical abstract

show abstract

Incidence of radiation-induced hypothyroidism following head and neck irradiation: a single-center analysis

Cited by 2 publications

References 37 publications

Analysis of correlative risk factors for radiation-induced hypothyroidism in head and neck tumors

Analysis of correlative risk factors for radiation-induced hypothyroidism in head and neck tumors

The Evaluation and Management of Visceral Complications in Radiation Fibrosis Syndrome Part 1

Contact Info

Product

Resources

About