Hypothyroidism with elevated pancreatic amylase and lipase without clinical symptoms: A case report

Abstract

BACKGROUND Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems. We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute pancreatitis. No such case has been previously reported. CASE SUMMARY A 29-year-old woman did not pay much attention to a fever 4 d prior. During this time, she experienced anorexia and only drank a small amount of water every day. She did not present with abdominal distension, postprandial nausea, vomiting, cough or expectoration. After physical and laboratory examinations, the patient was diagnosed with hypothyroidism. During the course of the disease, hypothyroidism was generally accompanied by constantly increased pancreatic amylase and trypsin. After admission, the possible etiology of the patient was excluded and the concentrations of pancreatic lipase and amylase in serum were > 2000U/L (reference range 23-300 U/L) and 410 U/L (reference range 30-110 U/L), respectively. So we highly suspected that it may be acute pancreatitis. Interestingly, she never developed any complications associated with acute pancreatitis despite high levels of serum pancreatic amylase and trypsin, and she reported no symptoms of abdominal pain. Serum amylase and lipase decreased gradually after active thyroxine supplementation, and the patient was discharged from the hospital after active treatment. CONCLUSION This case suggests that clinicians should pay attention to hypothyroidism with elevated pancreatic amylase and trypsin, even if no complications of acute pancreatitis are reported.

Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6

“…Blood samples were collected from all patients within 24 h of admission, and serum amylase and lipase activities were measured. The reference value of amylase was 25-125 U/l ( 13 ) and the reference value of lipase was 23-300 U/l ( 14 ). Abdominal CT scan was used as the standard imaging method and enhanced CT scan was performed on patients with an indefinite diagnosis ( Fig.…”

“… a Chi-squared test; b Kruskal-Wallis test; c One-way analysis of variance with Dunnett's test. The reference value of amylase was 25-125 U/l ( 13 ) and the lipase was 23-300 U/l ( 14 ). Values are expressed as n (%), median with interquartile range or mean ± standard error.…”

Analysis of the selenoprotein P (rs7579) gene polymorphism and expression in patients with chronic pancreatitis combined with hypothyroidism

“…Кількість хворих на ХП за останні два десятиліття зросла удвічі, що супроводжується високим рівнем інвалідизації і летальності (близько 15 %), переважно через онкопатологію [2]. Сучасні дослідження в галузі внутрішніх хвороб акцентують увагу на взаємодії гормонів щитоподібної залози з функцією органів шлунково-кишкового тракту [3,4].…”

Peculiarities of treatment of patients with comorbid pathology: chronic pancreatitis and hypothyroidism, taking into account SEPP1 gene polymorphism (RS7579)

“…Over the past two decades, the number of patients with CP has doubled, which is accompanied by a decrease in the quality of life, a high level of disability and a reduction in life expectancy (mortality is about 15 %, mainly due to oncopathology of the pancreas) [2]. In order to optimize the therapeutic schemes of these nosologies, modern research is aimed at studying the interaction of thyroid hormones with the function of the digestive organs [3,4]. Currently, it is believed that for the normal functioning of the thyroid gland, in addition to iodine, a number of elements are necessary, including selenium, zinc, copper and calcium [5].…”