Hypoxanthine, Xanthine and Uric Acid in Human Urine and in Decomposed Blood

Petersen, Birte Brandt; Jørni, J.; Jørgensen, S.

doi:10.3109/00365516509075360

SCLI

1965

DOI: 10.3109/00365516509075360

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Hypoxanthine, Xanthine and Uric Acid in Human Urine and in Decomposed Blood

Birte Brandt Petersen¹,

J. Jørni²,

S. Jørgensen³

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1967

1979

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Cited by 11 publications

(1 citation statement)

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“…Changes in the enzymatic regulation of the normal purine turnover will often be reflected quantitatively and/or qualitatively in the excretion of purine compounds in the urine. Examples of this in man are gout, xanthinuria, Lesch-Nyhan syn drome and certain diseases with immune defects (1,2,10,15).A few studies have been reported on the oxypurine excretion in the urine of normal adults (4,7,9,14), a single study on the excretion of uric acid in newborn infants (11), …”

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Oxypurine Excretion in Normal Newborn Infants

Jensen¹,

Jørgensen²

1977

Neonatology

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Hypoxanthine, xanthine, uric acid, 6-hydroxypurine, 2,6-hydroxypurine and 2,6,8-hydroxypurine, respectively, are the catabolic products of purine-containing compounds in the human body. Each of the compounds was determined, by enzymatic spectrophotometry, in the 24-hour urine samples of 23 newborn infants. The hypoxanthine excretions on the 1st, 2nd and 3rd days were 1.1 (0.7–1.6), 0.9 (0.1–1.4) and 0.7 (0.1–1.5) μmol/24 h/kg body weight. The xanthine excretion in the 1st, 2nd and 3rd days was: 0.5 (0.3–1.2), 0.6 (0.3–2.0) and 1.2 (0.4–1.9) μmol/24 h/kg body weight. The uric acid excretion in the 1st, 2nd and 3rd days was: 61 (33–150), 61 (20–142) and 76 (40–127) μmol/24 h/kg. All the values are given as median and 10% percentiles. The hypoxanthine excretion decreased significantly (p < 0.05) and the xanthine increased correspondingly throughout the 3 days (p < 0.05). The excretion of hypoxanthine plus xanthine showed no significant change throughout the 3 days, and comprised approximately 2.5% of the total oxypurine excretion.

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Oxypurine Excretion in Normal Newborn Infants

Jensen¹,

Jørgensen²

1977

Neonatology

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Uric acid accumulated in isolated kidney grafts: An assessment of agonal ischaemia

Buhl

1979

International Urology and Nephrology

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Hypoxanthine-xanthine washed out from kidney tissue during preservation has previously been found to be a reliable measure of the in vitro assessment of the deleterious effect of ischaemia on the functional regenerative ability of the graft. We have now studied the question: can uric acid accumulation in the isolated kidney graft be employed as a retrospective measure of the agonal ischaemia? We have found that uric acid alone accumulates in renal tissue during the agonal phase, in an amount that remains unchanged during the subsequent in vitro ischaemia. The determination of hypoxanthine-xanthine and uric acid in kidney perfusate samples during preservation must thus be presumed to be an optimal clinical-chemical method of assessing the graft ischaemia.

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Splanchnic organ adenine nucleotides and their metabolites in haemorrhagic shock

Cunningham

Keaveny

1977

Ir J Med Sci

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Hypoxanthine, Xanthine and Uric Acid in Human Urine and in Decomposed Blood

Cited by 11 publications

References 0 publications

Oxypurine Excretion in Normal Newborn Infants

Oxypurine Excretion in Normal Newborn Infants

Uric acid accumulated in isolated kidney grafts: An assessment of agonal ischaemia

Splanchnic organ adenine nucleotides and their metabolites in haemorrhagic shock

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