Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy

Xu, Feng; Li, Haidong; Yao, Qichao; Ge, Haoying; Fan, Jiangli; Sun, Wen; Wang, Jingyun; Peng, Xiaojun

doi:10.1039/c9sc03355f

Cited by 178 publications

(106 citation statements)

References 43 publications

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“…In comparison to the effects of other drug delivery systems, thermo‐sensitive hydrogels were reported to receive improvement for 61.5% over pure drug, [ 8 ] while photothermal sensitive materials combined with near‐infrared light achieved raise for 75% to 87% over pure drug, [ 9–11 ] thermosensitive composite combine with X‐ray gained more for 67% over pure drug, [ 12 ] and near‐infrared activated losartan enhanced penetration of doxorubicin improved for 72% over pure drug. [ 13 ] Newly published core‐shell nanocrystals co‐loaded with chemotherapy drug and photothermal agent realized volume inhibition for about 100% compared to normal saline, but it needed the aid of light irradiation, [ 14 ] which may have negative effect on normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Efficiently improving solid tumor therapy through shrinking the extracellular matrix and promoting drug transport in tumor tissue via simple and known functional materials

et al. 2020

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An effective chemotherapy through promoting drug transport in solid tumor is our concern here to avoid surgery and its side effects to our bodies. A drug delivery system, TXT-MNT-hydrogel, is constructed using temperature sensitive hydrogel nanoparticles and hydroxypropyl-β-cyclodextrin (HP-β-CD) to codeliver mannitol (MNT) and taxotere (TXT). TXT-MNT-hydrogel realizes weight inhibition in mice subcutaneous breast tumor for more 94% and 58% than TXT and a clinical used liposomes paclitaxel (Lipusu), and for more 91.4% and 85% than TXT-MNT and TXT-hydrogel as well. The mechanism is disclosed as (1) controlled taxotere and mannitol release from hydrogel nanoparticles and hydroxypropyl-β-cyclodextrin; (2) MNT shrinks the extracellular matrix of tumor tissue, and enhances the transport and bioavailability of drug in vivo for up to 2.7-fold versus no MNT in tumor surface, and from none to 0.5-2.5-fold versus the tumor surface of no MNT in the middle of tumor tissue in 12 hours, which results severer apoptosis in interior tumor cells than all the counterparts. This study certifies in vivo that the simple and published materials of MNT, TXT, HPβ-CD, and hydrogel in combination functionally augment solid tumor therapy, which provides a reference to construct more efficient drug delivery systems.

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Section: Discussionmentioning

confidence: 99%

Efficiently improving solid tumor therapy through shrinking the extracellular matrix and promoting drug transport in tumor tissue via simple and known functional materials

et al. 2020

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“…For deeper light penetration, i.e., more than a few millimeters, near-infrared (NIR) light within the range of wavelengths from 650 to 900 nm are mostly used in biomedical application [105]. Recently Xu et al, 2019, reported the NIR-based photosensitizers for photodynamic therapy [106].…”

Section: Light-responsive Drug Delivery Systems (Lrdds)mentioning

confidence: 99%

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim

Jan

Khan

et al. 2021

Cancers

137

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The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been carried out to investigate chemotherapy-based targeted drug delivery, the identification of the most promising strategy capable of bypassing non-specific cytotoxicity is still a major concern. Recent advancements in the arena of onco-targeted therapies have enabled safe and effective tumor-specific localization through stimuli-responsive drug delivery systems. Owing to their promising characteristic features, stimuli-responsive drug delivery platforms have revolutionized the chemotherapy-based treatments with added benefits of enhanced bioavailability and selective cytotoxicity of cancer cells compared to the conventional modalities. The insensitivity of stimuli-responsive drug delivery platforms when exposed to normal cells prevents the release of cytotoxic drugs into the normal cells and therefore alleviates the off-target events associated with chemotherapy. Contrastingly, they showed amplified sensitivity and triggered release of chemotherapeutic payload when internalized into the tumor microenvironment causing maximum cytotoxic responses and the induction of cancer cell necrosis. This review focuses on the physical stimuli-responsive drug delivery systems and chemical stimuli-responsive drug delivery systems for triggered cancer chemotherapy through active and/or passive targeting. Moreover, the review also provided a brief insight into the molecular dynamic simulations associated with stimuli-based tumor targeting.

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“…37 Thus, development of optical imaging probes is essential for highly specic anatomical and molecular imaging of the urinary system. To data, a great number of NIR uorescence (NIRF) probes have been used for detection of various cancer, [38][39][40][41][42][43] sentinel lymph nodes, 44 neurological diseases, [45][46][47] cardiovascular diseases, 48 hepatopathy. 49,50 In contrast, only a few probes have been reported for imaging diseases in the urinary system such as drug-induced AKI, iatrogenic and traumatic ureteral injury and bladder cancer ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases

Huang

2021

Chem. Sci.

107

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Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy

Abstract: Photodynamic therapy is considered as a promising treatment for cancer, but still faces several challenges.

Cited by 178 publications

References 43 publications

Efficiently improving solid tumor therapy through shrinking the extracellular matrix and promoting drug transport in tumor tissue via simple and known functional materials

Efficiently improving solid tumor therapy through shrinking the extracellular matrix and promoting drug transport in tumor tissue via simple and known functional materials

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases

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