2013
DOI: 10.1016/j.cellimm.2013.03.007
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Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes

Abstract: We report here that culture of lymphoid cells under hypoxic conditions showed an increase in both luciferase expression from a GH-promoter luciferase construct and the levels of lymphocyte GH. The effect was mimicked by treatment of cells with cobalt chloride consistent with a specific oxygen-sensing mechanism. We identified a putative hypoxia response element (HRE) in the GH promoter at the region −176 bp to −172 bp that contains a copy of the hypoxia-inducible factor-1 (Hif-1) binding motif (5′-ACGTG-3′). Th… Show more

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Cited by 8 publications
(8 citation statements)
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“…Lymphocyte decrease in cancer patients reflects host immune function due to hormonal change, malnutrition, antitumor immune response, or may be due to chemotherapy induced depletion (30)(31)(32)(33)(34)(35)(36) . Lymphopenia has strong relationship with lower heart ejection fraction postoperatively (37) , major adverse cardiac outcomes (38)(39)(40) and infectious complications (36) .…”
Section: Discussionmentioning
confidence: 99%
“…Lymphocyte decrease in cancer patients reflects host immune function due to hormonal change, malnutrition, antitumor immune response, or may be due to chemotherapy induced depletion (30)(31)(32)(33)(34)(35)(36) . Lymphopenia has strong relationship with lower heart ejection fraction postoperatively (37) , major adverse cardiac outcomes (38)(39)(40) and infectious complications (36) .…”
Section: Discussionmentioning
confidence: 99%
“…In a recent work, we showed that GH production by cells of the immune system increases under conditions of hypoxia perhaps via a HIF-1 sensitive response element located in the GH promoter [21]. Aging, which is associated with declining tissue oxygenation, may then be associated with an increase in lymphocyte GH and regulation of the immune response.…”
Section: Discussionmentioning
confidence: 99%
“…There is also strong evidence that oxygen limitation and/or activation of HIF-1 plays an important role in mammalian cellular senescence, possibly via a connection to ROS and mitochondrial respiration [53;54]. In this context, the substantial increase in GH production by T cells during hypoxia [21] may specifically increase T cell survival and/or enhance the ability of T cells to provide optimal help to B cells during a normal aging immune response. Thus, T cell overproduction or lack of GH production may play a role in certain autoimmune diseases or immunodeficiencies, respectively.…”
Section: Discussionmentioning
confidence: 99%
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“…For instance, it is reported that growth hormone expression in lymphocytes and parathyroid hormone-related protein in articular chondrocytes can be induced by hypoxia [20,21]. We postulate that if similar biology could be expressed in the head and neck region, HIF or hypoxia may bring profound efects on the growth and development of orofacial structures.…”
Section: Hypoxia In the Oral/periodontal Environmentmentioning
confidence: 94%