Hypoxia/IL‐1α axis promotes gastric cancer progression and drug resistance

Yao, Xuan; Wang, Ya Nong

doi:10.1111/1751-2980.12496

Cited by 22 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a critical role for the IL-1 pathway, in relation to therapy, is emerging in different types of solid tumors [63][64][65][66]. Specifically, several studies proposed a role for IL-1 in the poor responses to EGFR blockade and radiotherapy [67] with consequent treatment failures.…”

Section: Il-1 and Resistance To Targeted Therapymentioning

confidence: 99%

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

Gelfo

Romaniello

Mazzeschi

et al. 2020

IJMS

123

View full text Add to dashboard Cite

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response, IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathological conditions. In particular, IL-1 is known to exert a critical function in malignancies, influencing the tumor microenvironment and promoting cancer initiation and progression. Thus, it orchestrates immunosuppression recruiting pro-tumor immune cells of myeloid origin. Furthermore, new recent findings showed that this cytokine can be directly produced by tumor cells in a positive feedback loop and contributes to the failure of targeted therapy. Activation of anti-apoptotic signaling pathways and senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cells refractory to standard therapies needs to be further investigated.

show abstract

Section: Il-1 and Resistance To Targeted Therapymentioning

confidence: 99%

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

Gelfo

Romaniello

Mazzeschi

et al. 2020

IJMS

123

View full text Add to dashboard Cite

show abstract

“…IL-1a, a key inflammatory cytokine, is frequently upregulated in a variety of cancers and it is shown to be associated with development, invasion, metastasis as well as prognosis of cancer. [19][20][21][35][36][37][38][39] It has been proposed that a functional 4-bp ins/del variant in the 3′UTR of IL1A alters miR-122 and miR-378 mediated regulation of IL-1α expression. 7,25,40 We designed a rapid and reproducible mismatch PCR-RFLP method for detection of 4-bp ins/del variant of IL1A gene.…”

Section: Discussionmentioning

confidence: 99%

4‐bp insertion/deletion (rs3783553) polymorphism within the 3′UTR of IL1A contributes to the risk of prostate cancer in a sample of Iranian population

Hashemi

Bahari

Sarhadi

et al. 2017

J of Cellular Biochemistry

View full text Add to dashboard Cite

Growing evidence demonstrated the presence of an association between IL1A rs3783553 polymorphism and the risk of various cancers. We aimed to evaluate whether the 4-bp insertion/deletion polymorphism (rs3783553) within the 3' untranslated region (3'UTRs) of IL1A was associated to the risk of prostate cancer (PCa) in a sample of Iranian population. A case-control study, including 150 prostate cancer patients and 155 healthy men, was done to examine the possible association between IL1A 4-bp ins/del polymorphism and PCa risk in a sample of southeast Iranian population. Mismatched polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was designed for genotyping the studied variant. Our findings showed that 4-bp ins/del polymorphism significantly increased the risk of PCa in codominant, recessive and allelic inheritance model. We also evaluated the association between the IL1A 4-bp ins/del polymorphism and clinicopathological characteristics of the patients, and found a significant association between 4-bp ins/del variant and stage, perineural invasion and surgical margin of tumor samples. Bioinformatics analysis revealed that the ins/del variant affected the IL1A mRNA stability leading to a structural shift in IL1A mRNA and has-miR-125a-3p hybrid. In conclusion, our findings proposed an association between IL1A 4-bp ins/del polymorphism and PCa risk. Additional studies with enlarged sample size and diverse ethnicities are required to validate our finding.

show abstract

“…Support for the role of hypoxia combined with inflammation in chemosensitivity is provided by Xuan and Wang (180), who showed that the inflammatory cytokine, IL-1a, was upregulated in gastric cancer during hypoxia and had a positive correlation with tumour stage, lymph node metastasis and resistance to cisplatin (180). Huang et al (181) showed that HIF-1a stimulates COX-2 expression, invasion, metastasis, and EMT after transcatheter arterial chemoembolisation treatment in hepatocellular carcinoma patients, which contributed to poor prognosis (181).…”

Section: Hypoxia and Inflammation Crosstalk In Cancer Treatmentmentioning

confidence: 99%

Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma

Nasry

Martin

2021

Front. Oncol.

View full text Add to dashboard Cite

The importance of inflammation in the pathogenesis of cancer was first proposed by Rudolph Virchow over 150 years ago, and our understanding of its significance has grown over decades of biomedical research. The arachidonic acid pathway of inflammation, including cyclooxygenase (COX) enzymes, PGE2 synthase enzymes, prostaglandin E2 (PGE2) and PGE2 receptors has been extensively studied and has been associated with different diseases and different types of cancers, including oral squamous cell carcinoma (OSCC). In addition to inflammation in the tumour microenvironment, low oxygen levels (hypoxia) within tumours have also been shown to contribute to tumour progression. Understandably, most of our OSCC knowledge comes from study of this aggressive cancer in human patients and in experimental rodent models. However, domestic animals develop OSCC spontaneously and this is an important, and difficult to treat, form of cancer in veterinary medicine. The primary goal of this review article is to explore the available evidence regarding interaction between hypoxia and the arachidonic acid pathway of inflammation during malignant behaviour of OSCC. Overlapping mechanisms in hypoxia and inflammation can contribute to tumour growth, angiogenesis, and, importantly, resistance to therapy. The benefits and controversies of anti-inflammatory and anti-angiogenic therapies for human and animal OSCC patients will be discussed, including conventional pharmaceutical agents as well as natural products.

show abstract

Hypoxia/IL‐1α axis promotes gastric cancer progression and drug resistance

Abstract: The IL-1α/hypoxia axis may be a valuable target for diagnosis and treatment of GC.

Cited by 22 publications

References 28 publications

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

4‐bp insertion/deletion (rs3783553) polymorphism within the 3′UTR of IL1A contributes to the risk of prostate cancer in a sample of Iranian population

Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma

Contact Info

Product

Resources

About