Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma

Tse, Alex Wing Cheung; Li, Jing‐Woei; Chan, Ting‐Fung; Wu, Renren; Lai, Keng Po

doi:10.1016/j.aquatox.2015.06.002

Cited by 33 publications

(13 citation statements)

References 48 publications

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“…Hypoxia is a common feature of many solid tumours, including CRC, and is implicated in the regulation of many genes. miR-210 is the most consistently and robustly induced miRNA under hypoxia and generally exhibits carcinogenic properties in various tumours (Dang & Myers 2015;Guo et al 2015;Tse et al 2015). In our previous study, we found that the hypoxia-inducible miR-210 is an independent prognostic factor and contributes to metastasis in CRC (Qu et al 2014).…”

Section: Discussionmentioning

confidence: 76%

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Circulating miR-210 as a diagnostic and prognostic biomarker for colorectal cancer

Wang

Liu

et al. 2016

Eur J Cancer Care

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microRNA-210 (miR-210), the master hypoxamir, is overexpressed and generally exhibits oncogenic properties in most human solid tumours, including colorectal cancer (CRC). However, the status of circulating miR-210 in CRC is still unknown. This study aims to assess the clinical significance of circulating miR-210 in CRC. Using (reverse transcription quantitative PCR) RT-qPCR analysis, we compared the expression levels of circulating miR-210 in serum of 268 CRC patients and 102 healthy controls, and found that serum miR-210 was significantly higher in CRC than in healthy controls (P < 0.001). The area under the receiver operating characteristic curve (AUC) of circulating miR-210 to detect CRC was 0.821, with a sensitivity of 74.6% and a specificity of 73.5%. The AUC of circulating miR-210 showed significantly higher detection capability than that of carcinoembryogenic antigen (P < 0.05). Kaplan-Meier analysis demonstrated that increased serum miR-210 level correlated with reduced overall survival (OS) and disease-free survival (DFS) (P = 0.008 and P = 0.008 respectively). Cox analysis indicated circulating miR-210 was an independent prognostic factor for OS and DFS. Taken together, our data suggested that circulating miR-210 could be a potential non-invasive marker for diagnosis and prognosis of CRC.

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Section: Discussionmentioning

confidence: 76%

“…; Tse et al . ). In our previous study, we found that the hypoxia‐inducible miR‐210 is an independent prognostic factor and contributes to metastasis in CRC (Qu et al .…”

Section: Discussionmentioning

confidence: 97%

Circulating miR-210 as a diagnostic and prognostic biomarker for colorectal cancer

Wang

Liu

et al. 2016

Eur J Cancer Care

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“…Moreover, ectopic expression of miR-210 would result in downregulation of these apoptotic genes. On the other hand, the inhibition of miR-210 promoted apoptotic cell death and the expression of apoptotic markercaspase 3 in follicular cells under hypoxic treatment, supporting the regulatory role of miR-210 in ovarian cell apoptosis [38].…”

Section: Fig 1 Schematic Representation Of the Role Of Tumor Necrosmentioning

confidence: 67%

“…Certain miRNAs that regulate apoptotic genes including miR-210 can be induced by hypoxia, resulting in cell apoptosis. Tse et al [38] observed a significant induction of miR-210 in primary ovarian follicular cells exposed to hypoxia, and gene ontology analysis further highlighted the potential roles of miR-210 in cell proliferation, cell differentiation, and cell apoptosis through a number of miR-210 target apoptotic genes, including TNFRSF10B/DR5, deleted in liver cancer 1 protein (DLC1), STE20-like serine/threonine-protein kinase (SLK), RNA binding motif protein 25 (RBM25), and ubiquitin-specificprocessing protease 7 (USP7) [38]. Moreover, ectopic expression of miR-210 would result in downregulation of these apoptotic genes.…”

Section: Fig 1 Schematic Representation Of the Role Of Tumor Necrosmentioning

confidence: 99%

The role of the TNF receptors and apoptosis inducing ligands in tumor growth

Minchenko¹,

Tsymbal²,

Minchenko³

et al. 2016

Ukr.Biochem.J.

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Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth. The TNF-related pathways are controlled by endoplasmic reticulum stress signaling, which has a crucial role in the control of cell proliferation and tumor growth. Furthermore, the inhibition of IRE1 (inositol requiring enzyme-1), which is a central mediator of endoplasmic reticulum stress sand mainly responsible for cell proliferation and apoptosis, leads to suppression of tumor growth through specific changes in the expression of genes encoding transcription factors, tumor suppressors, angiogenesis and apoptosis related proteins, including TNF superfamily receptors and TNF apoptosis inducing ligands. Therefore, changes in the expression level of TNF-related genes encoding TNF superfamily receptors and apoptosis inducing ligands possibly reflect metabolic reprogramming of cancer cells upon inhibition of IRE1-mediated endoplasmic reticulum stress signaling and correlate with suppression of glioma cell proliferation.

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“…Ectopic expression of miR‐210 can lead to the downregulation of DLC1 in primary ovarian follicular cells of the marine medaka. Conversely, the inhibition of miR‐210 would upregulate DLC1, which promotes apoptotic cell death under hypoxic treatment (Tse, Li, Chan, Wu, & Lai, ). In addition, DLC1 interacts with the Wnt/β‐catenin signaling pathway, which is possibly essential in apoptosis in SW480 cells (Wang et al, ).…”

Section: The Function and Signal Pathways Dlc1 Involvesmentioning

confidence: 99%

A tumor suppressor DLC1: The functions and signal pathways

Zhang

2019

Journal Cellular Physiology

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Deleted in liver cancer‐1 (DLC1), a potential tumor suppressor, acts as a GTPase‐activating protein for Rho family members. In many human cancers, the DLC1 expression is frequently downregulated or inactivated, which allows cancer cells to proliferate and disseminate. In this review, we describe the characteristics and other members of the DLC1 family and delineate the signal pathways DLC1 involved in regulating cancer cell growth, colony formation, apoptosis, senescence, autophagy, migration and invasion. In addition, we explore the clinical data of DLC1 and the mechanisms that natural products upregulate the DLC1 expression to inhibit cancer. Despite these insights, many important unanswered questions remain about the exact mechanisms of DLC1‐mediated cancer suppression.

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Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma

Cited by 33 publications

References 48 publications

Circulating miR-210 as a diagnostic and prognostic biomarker for colorectal cancer

Circulating miR-210 as a diagnostic and prognostic biomarker for colorectal cancer

The role of the TNF receptors and apoptosis inducing ligands in tumor growth

A tumor suppressor DLC1: The functions and signal pathways

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