Hypoxia‐inducible factor 1<i>α</i> in oral cancer

Brennan, Peter A.; Mackenzie, N; Quintero, Marisol

doi:10.1111/j.1600-0714.2005.00335.x

Cited by 47 publications

(42 citation statements)

References 36 publications

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“…This is reinforced in our study in which correlations between hypoxia and biological aggression of the tumours (such as depth of invasion, mandibular invasion, involved cervical lymph nodes and extra-capsular spread) were seen. The cellular response to hypoxia seems to be mediated by HIF1A in malignancy (Maxwell, 2005) and has been extensively studied in HNSCC (Brennan et al, 2005;Quintero et al, 2006). Should Cygb prove to be a critical component in the hypoxia response, its manipulation might have therapeutic value, particularly in response to radiation treatment.…”

Section: Discussionmentioning

confidence: 99%

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Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer

et al. 2009

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BACKGROUND: Cytoglobin (Cygb) was first described in 2002 as an intracellular globin of unknown function. We have previously shown the downregulation of cytoglobin as a key event in a familial cancer syndrome of the upper aerodigestive tract. METHOD: Cytoglobin expression and promoter methylation were investigated in sporadic head and neck squamous cell carcinoma (HNSCC) using a cross-section of clinical samples. Additionally, the putative mechanisms of Cygb expression in cancer were explored by subjecting HNSCC cell lines to hypoxic culture conditions and 5-aza-2-deoxycitidine treatment. RESULTS: In clinically derived HNSCC samples, CYGB mRNA expression showed a striking correlation with tumour hypoxia (measured by HIF1A mRNA expression P ¼ 0.013) and consistent associations with histopathological measures of tumour aggression. CYGB expression also showed a marked negative correlation with promoter methylation (P ¼ 0.018). In the HNSCC cell lines cultured under hypoxic conditions, a trend of increasing expression of both CYGB and HIF1A with progressive hypoxia was observed. Treatment with 5-aza-2-deoxycitidine dramatically increased CYGB expression in those cell lines with greater baseline promoter methylation. CONCLUSION: We conclude that the CYGB gene is regulated by both promoter methylation and tumour hypoxia in HNSCC and that increased expression of this gene correlates with clincopathological measures of a tumour's biological aggression.

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Section: Discussionmentioning

confidence: 99%

“…In particular it seems to be related to resistance to radiotherapy (Koukourakis et al, 2006) and chemotherapy. The cellular response to hypoxia seems to be mediated by HIF1A in malignancy (Maxwell, 2005) and has been extensively studied in HNSCC (Brennan et al, 2005;Quintero et al, 2006).…”

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confidence: 99%

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer

et al. 2009

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“…Most tumors develop regions of chronically or transiently hypoxic cells during growth (2). Hypoxic tumor regions may show increased expression of many genes because of hypoxia-induced activation of transcription factors (3)(4)(5). Low extracellular pH, glucose depletion, high lactate levels, and regions with low oxygen tension (6, 7) characterize most tumors.…”

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confidence: 99%

Hypoxia Regulates Cross-talk between Syk and Lck Leading to Breast Cancer Progression and Angiogenesis

Chakraborty

Rangaswami

Jain

et al. 2006

Journal of Biological Chemistry

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“…Hyperglycemia also increases the agglutination of blood cells, which causes microembolization, blood vessel obstruction and hypoxia (26). As non-oxidative anabolic pathways play a leading role in tumor cell metabolism, these cells are able to multiply even in hypoxic conditions (27) In cases of diabetes, elevated glucose levels potentiate ribose generation and DNA replication by tumor cells (28). Hyperglycemia also promotes the spread of carcinomas and tissue damage due to the Glut-1 glucose transporter.…”

Section: Discussionmentioning

confidence: 99%

Type-2 Diabetes Mellitus and Oral Tumors in Hungary: A Long-term Comparative Epidemiological Study

Végh

Bányai

Hermann

et al. 2017

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Diabetes is considered an endemic medical condition with increasing prevalence globally. This tendency has been also detected in Hungary where the prevalence of diabetes among the adult population reached 7% according to the latest statistical data (1). Numerous data from several medical publications have shown that diabetes is a promoting factor in the formation of malignant tumors at different sites and has a negative impact on tumor progression and patient survival (2-16). Our medical research team has long studied the correlations between oral cavity cancer and diabetes, mainly type 2 diabetes (17, 18). Since type-2 diabetes has rapidly increased in prevalence globally and the morbidity and mortality rates of oral cavity cancer -especially in Hungary-do not show any significant decrease, we examined the relationship between glucose metabolic disorders and oral cancer in our clinic over the past 14 years. In the present study, we analyzed data of 758 patients with oral cavity cancer and 534 tumor-free control patients and examined the prevalence of diabetes and impaired fasting glucose (IFG), the distribution of tumor location and the role of smoking. Additionally, we compared our current results to data obtained 14 years ago. Patients and MethodsWe conducted a retrospective research study in the inpatient ward of the Semmelweis University Department of Oral and Maxillofacial Surgery, Budapest, Hungary. We examined patients who were diagnosed with histologically confirmed malignant oral tumors. The examination period was between the 1st of January, 2012 and 31st of December, 2015. These results were compared to an earlier study that was conducted in the same Department between the 1st of January, 1998 and 30th of June, 2002. We processed the data of 610 patients (435 males and 175 females) in the first interval and the data of 758 patients (400 male and 358 female) in the second interval. All patients were diagnosed with histologically confirmed malignant cancer. Based on these histological data, we confirmed that 606 cases among the 610 and 749 cases among the 758 were squamous cell carcinomas, while the remainder consisted of adenocarcinomas. The average age of the patients from the previous study was 56 years (range=36-85), whereas the average age of the patients in the follow-up study was 64 years (range=12-92).The control group in the first research interval was formed by 574 patients (351 male, 223 female). Their average age was 51 years (range=32-79).The control group in the second study interval was formed by 534 patients (318 male, 216 female) with an average age of 53 years (range=30-94). The patients of the control group in both study intervals volunteered for stomato-oncological screening and found symptom-and cancer-free.We considered patients with diabetes mellitus (DM) to be those who had been previously diagnosed and treated for diabetes by an internist or diabetologist. We classified patients into the IFG group when their fasting blood glucose values were between 6.1 and 6.9 mmol/l. We cons...

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Hypoxia‐inducible factor 1α in oral cancer

Cited by 47 publications

References 36 publications

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer

Hypoxia Regulates Cross-talk between Syk and Lck Leading to Breast Cancer Progression and Angiogenesis

Type-2 Diabetes Mellitus and Oral Tumors in Hungary: A Long-term Comparative Epidemiological Study

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