Hypoxia Neonatorum Involvement: Pathophysiological Mechanisms of the Development and Bioregulatory Correction Means

Abstract

Prognosis of the formation of health and life quality in childhood is determined bythe successful intrauterine fetus development, specific features of the mother’s labor,as well as character of adaptation after birth. Hypoxia is a universal factor of thefetus lesion and neonate at the presence of perinatal risk factors. Hypoxia –ischemicencephalopathy/neonatal encephalopathy, the frequency of which constitute, dependingon the level of the population income in different countries from 1,5 till 10-20 casesper 1000 live-born, develops on account of the negative influence of hypoxia on theorganism. Discussion of the therapeutic corrections of the pathological conditions ofthe newborn period taking into account clinical-molecular aspects of their formationis significant from the standpoint of the remote consequences prevention of the hypoxialesions in the subsequent life years.Purpose – to determine the efficacy of bio-regulatory correction means in the treatmentof neonates with various forms of perinatal pathology, in the pathogenesis of whom thereis hypoxic involvement, on the basis of dynamics of the clinical-laboratory observationwith estimation, besides generally accepted criteria, indices of the energy metabolismcondition, system of free –radical oxidation and antioxidant defense of the organism.Material and methods. One-centered perspective investigation of 60 full-termnewborns, 30 of whom were administered traditional course of treatment (group I),accordingly, 30 neonates, besides generally accepted therapeutic complex, usedpreparations of bio-regulatory correction, in particular, Traumel C, CoenzymeCompositum and Cerebrum Compositum H (group II), has been carried out. Controlgroup for comparative evaluation of indices of the additional methods of investigationconstituted 30 healthy neonates (group III). Additional methods of investigation ofthe neonates included: complex of energetic exchange indices, system of free-radicaloxidation and anti-oxidation system of the body defense. Examination of children wasfulfilled by parents’ consent of the patients. Statistical analysis of the research resultsobtained was conducted using Statistica (StatSoftInc., USA, 2010) programme.Results. Dynamic observation of the newborns of the groups of comparison, taking intoconsideration differences of the prescribed treatment, has shown great efficiency of thetherapeutic correction in children, received, equally with traditional, means of bioregulatory correction. The usage of the mentioned group of preparations reduced theterms of the newborns treatment, that is indicative of the better adaptation possibilitiesof the organism after birth at endured hypoxia at the expense of energetic exchangestabilization and reduction of oxidative stress, promoting stabilization of the state inacute period of the diseases and reducing remote pathology consequences.Conclusions. 1. Investigation of the clinical-molecular mechanisms of hypoxiainvolvement of the organism in neonates in perinatal pathology requires complexapproach to increase efficiency methods of diagnostics and treatment. 2. Determinationof indices of energetic exchange, free-radical oxidation and antioxidant defense ofthe organism is an urgent diagnostic direction to reveal metabolic disorders, thatenables to administer therapeutic correction in proper time, directed at improvementof mitochondrial oxidation, preservation of the structure and function of the cellularmembranes. 3. Perspective direction is the studying of expediency of involvement of bioregulatory correction means, the subject of which is activation of the own regulatorydefense mechanisms, aimed at the formation of the short-term and prolonged adaptationof the organism after birth.