Hypoxia promotes stem-like properties of laryngeal cancer cell lines by increasing the CD133+ stem cell fraction

Wu, Chunping; Du, Huaidong; Gong, Hongli; Li, Dawei; Tao, Lei; Tian, Jie; Zhou, Liang

doi:10.3892/ijo.2014.2307

Cited by 32 publications

(22 citation statements)

References 36 publications

(47 reference statements)

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“…Similarly, Wu et al reported that hypoxia treatment of laryngeal cancer cell lines significantly expanded G0/G1 stage (a fundamental feature of stem cells) and increased the CD133 + CSC subpopulation . They also found that hypoxia increased the mRNA levels of stem cell genes NANOG, OCT4 , and SOX2 , as well as their protein levels . Consistent with the results in laryngeal cancer cells, another group independently reported that hypoxia exhibited similar effects on extending the G0/G1 stage and increasing the CD44 + and ABCG2 + cell populations in prostate cancer cells lines, PC3 and Du145 .…”

Section: Introductionmentioning

confidence: 54%

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Regulation of NANOG in cancer cells

Gong

Jeter

et al. 2015

Mol. Carcinog.

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As one of the key pluripotency transcription factors, NANOG plays a critical role in maintaining the self-renewal and pluripotency in normal embryonic stem cells. Recent data indicate that NANOG is expressed in a variety of cancers and its expression correlates with poor survival in cancer patients. Of interest, many studies suggest that NANOG enhances the defined characteristics of cancer stem cells and may thus function as an oncogene to promote carcinogenesis. Therefore, NANOG expression determines the cell fate not only in pluripotent cells but also in cancer cells. Although the regulation of NANOG in normal embryonic stem cells is reasonably well understood, the regulation of NANOG in cancer cells has only emerged recently. The current review provides a most updated summary on how NANOG expression is regulated during tumor development and progression.

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Section: Introductionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 83%

Regulation of NANOG in cancer cells

Gong

Jeter

et al. 2015

Mol. Carcinog.

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“…Another study suggested that laryngeal cancer cells, subjected to hypoxia followed by normoxia, exhibited enhanced capacities for proliferation, invasion, sphere, and colony formation in comparison with cells which were maintained consistently under normoxia. These events were associated with an increasing CD133+ fraction denoting regulation of cancer stem cells by hypoxic microenvironments 150 . Moreover, Zhu et al has demonstrated the role of HIF-1 in intermittent hypoxia on promoting the metastatic ability and invasiveness of CD133+ pancreatic cancer stem-like cells 151 .…”

Section: Side Population and Cd133mentioning

confidence: 99%

Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1

Doktorova

Hraběta

Khalil

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. The aim of this review is to provide the information about molecular basis of hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and therapeutic use. Results. Hypoxia is a common feature of tumors and represents an independent prognostic factor in many cancers. It is the result of imbalances in the intake and consumption of oxygen caused by abnormal vessels in the tumor and the rapid proliferation of cancer cells. Hypoxia-induced resistance to cisplatin, doxorubicin, etoposide, melphalan, 5-flouoruracil, gemcitabine, and docetaxel has been reported in a number of experiments. Adaptation of tumor cells to hypoxia has important biological effects. The most studied factor responsible for these effects is hypoxia-inducible factor-1 (HIF-1) that significantly contributes to the aggressiveness and chemoresistance of different tumors. The HIF-1 complex, induced by hypoxia, binds to target genes, thereby increasing the expression of many genes. In addition, the expression of hundreds of genes can be also decreased in response to hypoxia in HIF-1 dependent manner, but without the detection of HIF-1 in these genes' promoters. HIF-1 independent mechanisms for drug resistance in hypoxia have been described, however, they are still rarely reported. The first clinical studies focusing on diagnosis of hypoxia and on inhibition of hypoxia-induced changes in cancer cells are starting to yield results. Conclusions. The adaptation to hypoxia requires many genetic and biochemical responses that regulate one another. Hypoxia-induced resistance is a very complex field and we still know very little about it. Different approaches to circumvent hypoxia in tumors are under development.

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“…Hypoxia induced CSCs enriched in Hep-2 cells [51] and CD133+ cells isolated from freshly resected laryngeal tumor specimens [21] displayed significantly elevated OKS levels, pointing in their importance as critical CSCs biomarkers for LCa.…”

Section: Oct4 Klf4 and Sox2mentioning

confidence: 99%

Current cancer stem cell biomarkers in laryngeal cancer

Karataş¹,

Barlak²,

Şahin³

2017

The European Research Journal

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Larynx cancer (LCa), being an aggressive malignancy, is the second most commonly diagnosed malignant type of head and neck squamous cell carcinoma worldwide. Although there have been significant improvements in the detection and diagnosis of LCa in the last decades, it is still one of the considerable causes of cancer deaths and an urgent need for identification of novel biomarkers with diagnostic and prognostic significance still remains. The cancer stem cells (CSCs) resemble normal stem cells in terms of biological features and are considered to play critical roles in biological aggressiveness of tumors. Accumulating evidences have proven the existence of CSCs in various tumors including LCa and they are considered as driving force for tumor relapse, metastasis, and chemo-radioresistance. Comprehensive identification and characterization of the CSCs is of paramount importance for their further characterization to develop more effective and targeted therapeutic strategies against cancer. Here, we reviewed and summarized the most current literature to provide an insight into the functions and roles of current CSCs biomarkers in human LCa. We believe that this review will contribute to the knowledge of scientists especially working with LCa CSCs and will help understanding the significance of CSCs biomarkers implicated in LCa pathogenesis.

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Hypoxia promotes stem-like properties of laryngeal cancer cell lines by increasing the CD133+ stem cell fraction

Cited by 32 publications

References 36 publications

Regulation of NANOG in cancer cells

Regulation of NANOG in cancer cells

Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1

Current cancer stem cell biomarkers in laryngeal cancer

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