Hypoxic-Ischemic Injury: Utility of Susceptibility-Weighted Imaging

Kitamura, Gene; Kido, Daniel K.; Wycliffe, Nathaniel; Jacobson, Paul H.; Oyoyo, Udochukwu; Ashwal, Stephen

doi:10.1016/j.pediatrneurol.2011.06.009

Cited by 30 publications

(33 citation statements)

References 23 publications

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“…In children with hypoxic-ischemic injury-where there was an increase in deoxygenated hemoglobin but no increase in venous pressure-the medullary veins were more prominent than the subependymal veins, which were less consistently present in general and were prominent only when the medullary veins were moderately to extremely prominent. 16 In the current study, the subependymal veins were always more prominent than the medullary veins. If the subependymal veins are larger than normal in hydrocephalus, then the pressure within them must be elevated over and above the elevated CSF pressure, and this indicates that the flowlimiting resistance must be further downstream than these segments-that is, within the sinuses.…”

Section: Susceptibility Weighted Mrisupporting

confidence: 44%

“…Thus, susceptibility weighted scans have been used to measure the size of the medullary veins in multiple sclerosis 14 and in neonatal hypoxic-ischemic injury. 16 In the latter condition, the increased prominence of the medullary veins has been associated with a worsening outcome as well as both dilation of the veins and an increase in deoxygenated hemoglobin. 16 In the current study, the subependymal veins were twice as prominent in acute hydrocephalus as in the normal state, and although some of this increase may be attributable to an increase in deoxygenated hemoglobin, the veins were probably dilated as well.…”

Section: Susceptibility Weighted Mrimentioning

confidence: 99%

“…16 In the latter condition, the increased prominence of the medullary veins has been associated with a worsening outcome as well as both dilation of the veins and an increase in deoxygenated hemoglobin. 16 In the current study, the subependymal veins were twice as prominent in acute hydrocephalus as in the normal state, and although some of this increase may be attributable to an increase in deoxygenated hemoglobin, the veins were probably dilated as well. In children with hypoxic-ischemic injury-where there was an increase in deoxygenated hemoglobin but no increase in venous pressure-the medullary veins were more prominent than the subependymal veins, which were less consistently present in general and were prominent only when the medullary veins were moderately to extremely prominent.…”

Section: Susceptibility Weighted Mrimentioning

confidence: 99%

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Hemodynamically significant venous collapse underlying neonatal hydrocephalus

Bateman¹

2014

PED

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Object It is known that CSF diversion in neonatal hydrocephalus can significantly increase cerebral blood flow, suggesting that a rapidly reversible elevation in vascular resistance underlies this disorder. Various sites of vascular compression have been described in the literature, from the arterioles to the capillary bed to the venules and sinuses. The purpose of this study was to define the site of the hemodynamically significant vascular compression seen in neonatal hydrocephalus. Methods The author performed a retrospective review of all patients who, in the first 28 days of life, had undergone 3-T MRI examination, including MR venography and susceptibility weighted scanning, at a tertiary care referral hospital in the period from April 2010 to April 2013. The maximum size of the subependymal veins over the thalamus and transverse sinuses was measured. Results Three children with hydrocephalus were identified, and 10 children with a normal ventricular size served as controls. The subependymal veins were twice as prominent and the transverse sinuses were half as large in the patients with hydrocephalus compared with those in controls. Conclusions The hemodynamically significant elevation in vascular resistance, which occurs in neonatal hydrocephalus, appears to be located in the venous sinuses.

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Section: Susceptibility Weighted Mrisupporting

confidence: 44%

Section: Susceptibility Weighted Mrimentioning

confidence: 99%

Section: Susceptibility Weighted Mrimentioning

confidence: 99%

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Hemodynamically significant venous collapse underlying neonatal hydrocephalus

Bateman¹

2014

PED

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“…Our method could increase the prognostic value of these SWIs, thereby it improves the management of the illness as well as elucidates the disease mechanisms. This method can also be extended to estimate different MR scores [17,19] assigned by specialists to HIE infants. Such an extension is an interesting topic for our future work.…”

Section: Discussionmentioning

confidence: 99%

“…Susceptibility weighted imaging (SWI) is a type of MR image; an SWI image highlights the cerebral venous vasculature, reflecting abnormalities in blood flow and oxygenation which may be linked to adverse outcomes. A qualitative score based on MRI analyses can be assigned to SWIs by specialists to provide an assessment of the degree of severity of an abnormality in an HIE patient [19].…”

Section: Introductionmentioning

confidence: 99%

Feature Extraction and Classification to Diagnose Hypoxic-Ischemic Encephalopathy Patients by Using Susceptibility-Weighted MRI Images

Mahmoodi

Darekar

et al. 2017

Communications in Computer and Information Science

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Abstract. In this paper. a method is presented to enable automatic classification of the degree of abnormality of susceptibility-weighted images (SWI) acquired from babies with hypoxic-ischemic encephalopathy (HIE), in order to more accurately predict eventual cognitive and motor outcomes in these infants. SWI images highlight the cerebral venous vasculature and can reflect abnormalities in blood flow and oxygenation, which may be linked to adverse outcomes. A qualitative score based on magnetic resonance imaging (MRI) analyses is assigned to SWIs by specialists to determine the severity of abnormality in an HIE patient. The method allows the detection of image ridges, representing the vessels in SWIs, and the histogram of the ridges grey scales. A curve with only four parameters is fitted to the histograms. These parameters are then used to estimate the SWI abnormality score. The images are classified by using a kNNand multiple SVM classifiers based on the parameters of the fitting curves. The algorithm is tested on an SWI-MRI dataset consisting of 10 healthy infants and 48 infants with HIE with a range of SWI abnormality scores between 1 and 7. The accuracy of classifying babies with HIE vs. those without (ie: healthy controls) using our algorithm with a leave-one-out strategy is measured as 91.38%. Our method is fast and could increase the prognostic value of these scans, thereby improving management of the condition, as well as elucidating the disease mechanisms of HIE.

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Perinatal and Early Postnatal Factors Underlying Developmental Delay and Disabilities

Ergaz¹,

Ornoy²

2011

Dev Disabil Res Revs

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A delay in meeting developmental milestones may be secondary to perinatal events, involving complicated interactions between mother and fetus during delivery. Maternal factors including weight, diet, and morbidities can affect neonatal adaptation and later development. Prematurity, low birth weight, and previous intrauterine insults as well as complications during delivery of a previously normal fetus increase the risk for perinatal stress. In this article, the literature on perinatal and early postnatal factors that underlie risks for developmental delay and disabilities is reviewed. Studies that concern neuroprotective therapies and prediction of long-term neurologic outcome by clinical examination, neuroimaging techniques, and electroencephalographic studies are reviewed as well.

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Hypoxic-Ischemic Injury: Utility of Susceptibility-Weighted Imaging

Cited by 30 publications

References 23 publications

Hemodynamically significant venous collapse underlying neonatal hydrocephalus

Hemodynamically significant venous collapse underlying neonatal hydrocephalus

Feature Extraction and Classification to Diagnose Hypoxic-Ischemic Encephalopathy Patients by Using Susceptibility-Weighted MRI Images

Perinatal and Early Postnatal Factors Underlying Developmental Delay and Disabilities

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