Hypoxic regulation of plasminogen activator inhibitor‐1 expression in human buccal mucosa fibroblasts stimulated with arecoline

Tsai, Chien-Chung; Lee, Shiuan-Shinn; Chang, Yu‐Chao

doi:10.1111/jop.12284

Cited by 29 publications

(14 citation statements)

References 26 publications

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“…Incidentally, HIF‐1α has been shown to upregulate various profibrotic mediators such as basic fibroblast growth factor, vasculoendothelial growth factor, TGF‐β 1 , connective tissue growth factor (CTGF), and ET‐1 either directly or indirectly . Also, HIF‐1α has been shown to augment plasminogen activator inhibitor‐1, leading to fibrin accumulation and thus OSF . It is not surprising though that the degree of epithelial dysplasia has shown to turn severe with an increase in the extent of fibrosis in OSF .…”

Section: Discussionmentioning

confidence: 99%

Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies

Sharma

Radhakrishnan

2016

J Oral Pathology Medicine

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Limited mouth opening (LMO) in oral submucous fibrosis (OSF) has been attributed to both the submucosal and muscle fibrosis (MF). While reflectory trismus was proposed before as an auxiliary mechanism by another group, the stretch-mediated muscle damage (MSD), histopathological changes in blood vessels (such as endothelial dysfunction, endothelial hypertrophy, and endarteritis obliterans), and upregulated anaerobic isoforms of lactate dehydrogenase (LDH) have been proposed by us as complementary events leading to MF. Additionally, the amount of hypoxia-mediated upregulation of anaerobic isoforms of LDH determines the extent of MF. Radiotherapy (RT)-mediated release of reactive oxygen species causes vascular damage thereby worsening hypoxia. While the alteration in LDH levels secondary to hypoxia enhances fibrosis, RT worsens it. Oral squamous cell carcinoma occurring in the background of OSF is an absolute contraindication for RT as it augurs unfavorable prognosis. An algorithm to demonstrate this with evidence is clearly depicted. The role of HIF-1α in the progression of OSF and its malignant transformation, and the consideration of hyperbaric oxygen therapy as a therapeutic remedy in OSF are underscored.

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Section: Discussionmentioning

confidence: 99%

Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies

Sharma

Radhakrishnan

2016

J Oral Pathology Medicine

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“…Arecoline activates another key chemical in the regulation of fibrosis -the hypoxia-inducible factor-1 alfa-in a dose dependent manner. 17 Most of the studies show an increase in the incidence of OSMF when pan and tobacco consumption are combined. A relative risk of 489 has been reported for OSMF in consumption of pan& tobacco compared with non-users.…”

Section: Discussionmentioning

confidence: 99%

Role of Pan Chewing in Oral Submucous Fibrosis - Our Experience

Anoop¹,

Bullar²,

Gupta³

et al. 2018

jebmh

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BACKGROUND Pan chewing causes Oral Sub-Mucous Fibrosis (OSMF) which is one of the major premalignant conditions of the oral cavity. It is seen mainly in South East Asia, Europe and North America. Malignant transformation to squamous cell carcinoma accounts for 2-3%. This risk is enhanced by the usage of pan and various tobacco products. MATERIALS AND METHODS We took up the present study in FH Medical College Etmadpur, Agra, from June 2017 to June 2018. 100 patients between the age group 21 years to 60 years where included in the study; who were attending outpatient department of ENT. RESULTS Most of them were having pan chewing as a habit. Pan chewing, tobacco chewing, and tobacco smoking were present in 16 patients. 78 patients were men. Most of the patients belonged to 30 to 39 age group. Conservative OPD treatment combined with surgical treatment gave good outcome in the treatment process. CONCLUSION We conclude that pan chewing and its various products has got strong association in the development of OSMF. Tobacco usage adds to the magnitude of the problem. Early diagnosis and treatment are important to prevent carcinomatous transformation.

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“…It was proposed that hypoxia is an important microenvironmental factor in OSF associated with betel quid chewing and its malignant transformation [57][58][59][60]. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of cellular responses to hypoxia and is strongly upregulated in various fibrotic diseases including OSF [61].…”

Section: Hypoxiamentioning

confidence: 99%

“…HIF-1α expression was significantly upregulated in the fibroblasts, epithelial cells, and inflammatory cells of betel quid chewers. Activated HIF-1α stimulates PAI-1 expression and induces extracellular matrix accumulation leading to OSF [58]. CD105 is a TGF-β signaling receptor and plays important roles in angiogenesis and fibrogenesis.…”

Section: Coding Gene and Protein Biomarkers In Osf Tissuesmentioning

confidence: 99%

Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy

Shih

Wang

Shieh

et al. 2019

IJMS

175

111

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Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.

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Hypoxic regulation of plasminogen activator inhibitor‐1 expression in human buccal mucosa fibroblasts stimulated with arecoline

Cited by 29 publications

References 26 publications

Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies

Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies

Role of Pan Chewing in Oral Submucous Fibrosis - Our Experience

Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy

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