Hysterectomy leads to fast improvement of haematological and immunological parameters in bitches with pyometra

Bartošková, A.; Vitášek, R.; Levá, Lenka; Faldyna, Martin

doi:10.1111/j.1748-5827.2007.00345.x

Cited by 32 publications

(25 citation statements)

References 19 publications

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“…This is similar to results reported by others (Kustritz, 2005;Bartoskova et al, 2007). Similarly, the 80% of bitches with high white blood cell count is consistent with other series (Kustritz, 2005;Verstegen et al, 2008).…”

Section: Discussionsupporting

confidence: 82%

Reproductive emergencies in the bitch: a retrospective study

Martins‐Bessa

Cardoso

Costa

et al. 2018

J Hellenic Vet Med Soc

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ABSTRACT. This study aimed at analyzing reproductive emergencies (RE) in bitches brought in to a general veterinary hospital during a 24 month-period; evaluating their clinical-epidemiological features; and assessing the results of applied therapy. RE accounted for 11.8% of all female dog emergency clinical cases. Pyometra and dystocia accounted for 56.0% and 32% of the RE, with three (Newfoundland, Siberian Husky, Chow-Chow) and nine breeds (Boston Terrier, French Bulldog, Bernese Mountain Dog, Yorkshire Terrier, St. Bernard, Maltese, Chihuahua, Doberman and Boxer) found at higher risk of pyometra and dystocia, respectively. Fifty-four (96.4%) cases of pyometra were surgically managed, with a mortality of 13.0%. Primary uterine inertia (19 cases) was the main cause (59.4%) of dystocia. Medical treatment was attempted in 23 cases of dystocia (71.9%) but found to be effective in only two of them, leading to a high percentage of caesarian sections (30/32 cases, 93.8%). Both pyometra and dystocia had a high percentage of success following surgery. The use of standardized diagnostic and treatment protocols for the approach of RE allowed favorable outcomes.

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Section: Discussionsupporting

confidence: 82%

Reproductive emergencies in the bitch: a retrospective study

Martins‐Bessa

Cardoso

Costa

et al. 2018

J Hellenic Vet Med Soc

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“…However, the nature of this acute glomerular dysfunction still needs to be defined 6 . There are no increased levels of circulating immune complexes in dogs with pyometra compared with healthy ones 14 . Other studies reported only tubulointerstitial lesions in dogs with pyometra 6,7 or even found no histological differences between healthy dogs and dogs with pyometra 9…”

mentioning

confidence: 99%

Escherichia coli Pyometra Induces Transient Glomerular and Tubular Dysfunction in Dogs

Maddens

Daminet

Smets

et al. 2010

Journal of Veterinary Internal Medicine

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Background: Pyometra in dogs has been associated with renal injury. Hypothesis: Examine pyometra-related nephropathy by evaluating novel renal biomarkers. Animals: Twenty-five dogs with Escherichia coli pyometra. Fourteen clinically healthy bitches of comparable age. Methods: Prospective study. Urinary biomarkers determined by immunoassays (uIgG, uCRP, uAlb, uRBP, uTXB 2 ) or colorimetric test (uNAG) with results normalized to urine creatinine concentration. Nonparametric Mann-Whitney U-test and Wilcoxon's signed-rank test used to compare healthy dogs and dogs with pyometra, and dogs with pyometra at initial and follow-up examination.Results: Urinary biomarkers (median, range) significantly increased in dogs with pyometra (uIgG/Cr: 169.7 mg/g, 4.8-1052.9; uCRP/Cr: 0.260 mg/g, 0.006-3.030; uAlb/Cr: 89.5 mg/g, 8.8-832.7; uRBP/Cr: 1.66 mg/g, 0.05-21.44; uNAG/Cr: 5.8 U/ g, 1.6-27.7; uTXB 2 /Cr: 15.3 mg/g, 3.2-139.6) compared with healthy bitches (uIgG/Cr: 3.4 mg/g, 0.6-8.9; uCRP/Cr: below detection limit; uAlb/Cr: 17.5 mg/g, 1.3-166.3; uRBP/Cr: 0.13 mg/g, 0.02-0.44; uNAG/Cr: 2.4 U/g, 1.4-7.4; uTXB 2 /Cr: 2.4 mg/g, 1.2-4.7) (P o .001). Six months after ovariohysterectomy, urinary biomarkers in pyometra group (uIgG/Cr: 4.7 mg/g, 1.5-99.8; uCRP/Cr: below detection limit; uAlb/Cr: 13.9 mg/g, 2.1-471.2; uRBP/Cr: 0.05 mg/g, 0.02-0.32; uNAG/Cr: 1.6 U/g, 0.9-3.3; uTXB 2 /Cr: 3.3 mg/g, 1.0-6.9) were significantly lower than before surgery (P o .01), and not significantly different to those of healthy dogs (P 4 .05).Conclusion and Clinical Importance: Pyometra-related renal dysfunction affects the nephron both at glomerular and proximal tubular level and is a transient process in most dogs with E. coli pyometra.

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“…Yet, the underlying changes in sex hormone levels during heat and dioestrus and subsequent physiological responses of the canine uterus are crucial for the onset and progression of pyometra (Johnston et al 2001, Noakes et al 2001Fransson and Ragle, 2003). The impaired immunological status of bitches with pyometra has already been described (Faldyna et al 2001a;Bartoskova et al 2007) but whether and to what extent sex hormones contribute to the immunological aspect (i.e. potentially altered susceptibility) of the development of this disease in bitches has remained open to question.…”

mentioning

confidence: 99%

The effects of in vitro exposure to progesterone and estradiol-17β on the activity of canine neutrophils

Bartošková¹,

Ondráčková²,

Levá³

et al. 2014

Vet. Med. - Czech

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ABSTRACT:To date, only limited information about the influence of ovarian hormones on canine immune system cells has been available. The study investigated the in vitro influence of progesterone and estradiol-17β on the activity of canine neutrophils. Treatment of cells by both hormones led to a significant decrease in phagocytosisinduced oxidative burst as detected using luminometry after stimulation with opsonised zymosan. The increase in oxidative burst, not connected with phagocytosis, was recorded after stimulation with a soluble stimulator. Using flow cytometry, the tendency of both hormones to decrease the production of reactive oxygen species associated with phagocytosis of Escherichia coli was also evident, although not significant. Suppression of canine neutrophil activity is not connected with pathogen recognition capabilities, since the expression of Toll-like receptor 4 was unaffected. This study reveals that both hormones have a suppressive effect on the activity of canine neutrophils and thus might contribute to the aetiology of pyometra.

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Hysterectomy leads to fast improvement of haematological and immunological parameters in bitches with pyometra

Abstract: Application of immunostimulating therapy is not necessary to manage changes in blood cell counts and suppression of lymphocyte activity in bitches with pyometra. Removal of the infected uterus, being the source of infection, leads to improvement.

Cited by 32 publications

References 19 publications

Reproductive emergencies in the bitch: a retrospective study

Reproductive emergencies in the bitch: a retrospective study

Escherichia coli Pyometra Induces Transient Glomerular and Tubular Dysfunction in Dogs

The effects of in vitro exposure to progesterone and estradiol-17β on the activity of canine neutrophils

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