HYT-Hypertension in Turkey: A Cross-Sectional Survey on Blood Pressure Control with Calcium Channel Blockers Alone or Combined with Other Antihypertensive Drugs

Seravalle, Gino; Koylan, Nevrez; Nalbantgil, İstemi; Çağlar, Nail; Quartı-Trevano, Fosca; Makel, Wim; Fıcı, Francesco

doi:10.1007/s40292-015-0091-6

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…This study revealed that 50.4% of hypertensive patients on outpatient follow-up controlled their BP over the last 6 months. This finding was higher than those of studies conducted in Turkey (31.7%), 13 Malaysia (48.3%), 14 Tanzania (47.7%), 15 Zimbabwe (32.8%), 17 Kenya (33.4%), 18 Uganda (35.9), 16 and similar study in Addis Ababa, Ethiopia (40.1%). 9 This difference is probably due to a change in the criteria used to classify hypertensive patients as having uncontrolled and controlled BP.…”

Section: Discussioncontrasting

confidence: 58%

“… 5 Many studies in different parts of the world show that uncontrolled BP is a common phenomenon among hypertensive patients on treatment. 8 – 11 Thus, BP was controlled for only less than 50% of the hypertensive patients in Japan, 12 31.7% in Turkey, 13 and 48.3% in Malaysia. 14 Controlling BP is a difficult experience in Africa too; BP control was accomplished for only 47.7% of the hypertensive patients on follow-up in Tanzania, 15 35.9% in Uganda, 16 32.8% in Zimbabwe, 17 33.4% in Kenya, 18 and 40.1% in Addis Ababa, Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, BP is less likely to be controlled among unmarried, 19 male, 20 elderly, 18 less educated, 14 low-income, 17 rural, 9 and unemployed 17 patients. Smoking, 13 , 17 salt addition habit in meal, 9 and alcohol drinking 17 are associated with poor BP control, whereas vegetable consumption habit 21 and moderate physical activity 22 , 23 are important behaviors to control BP. Having other comorbidities, like diabetes mellitus (DM) or renal diseases, 12 – 14 low adherence to anti-hypertensive treatments, 9 , 15 , 20 , 24 obesity/overweight, 13 , 15 , 17 being on multidrug regimen, 14 , 18 , 20 and lack of information on complications of HTN are also other factors associated with poor BP control.…”

Section: Introductionmentioning

confidence: 99%

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Blood pressure control status and associated factors among adult hypertensive patients on outpatient follow-up at University of Gondar Referral Hospital, northwest Ethiopia: a retrospective follow-up study

Animut¹,

Assefa²,

Lemma³

2018

IBPC

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BackgroundLarge segments of the hypertensive population in the world are either untreated or inadequately treated. The incidence of heart failure and mortality from cardiovascular complications of hypertension is high among patients with uncontrolled blood pressure (BP). But BP control status of hypertensive patients has not been investigated in the study area. The study aimed to assess BP control status and determinant factors among adult hypertensive patients on antihypertensive medication attending outpatient follow-up at University of Gondar Referral Hospital, northwest Ethiopia.MethodsAn institution-based retrospective follow-up study was conducted from September 2015 to April 2016. Data were collected using a structured and pretested questionnaire adopted from the World Health Organization STEPwise approach. BP records of 6 months were used, and patients were classified as having controlled BP if their BP readings were <140/90 mmHg for all adults ≥18 years of age and <150/90 mmHg for adults aged ≥60 years. A generalized estimating equation was fitted, and the odds ratio with a 95% confidence level was used to determine the effect of covariates on BP control status.ResultsAmong 395 participants, 50.4% (95% CI: 45–55) of them controlled their BP in the last 6 months of the survey. Physical activity (adjusted odds ratio [AOR]=1.95, 95% CI: 1.41–2.68), duration on antihypertensive drugs of 2–4 years (AOR=1.70, 95% CI: 1.13–2.56) and 5 years or more (AOR=1.96, 95% CI: 1.32–2.92), and high adherence (AOR=2.18, 95% CI: 1.14–4.15) to antihypertensive drugs were positively associated with BP control, while salt intake (AOR=0.67, 95% CI: 0.49–0.93), overweight (AOR=0.50, 95% CI: 0.36–0.68), and obesity (AOR=0.56, 95% CI: 0.36–0.87) were inversely associated with BP control.ConclusionIn this study, only half of the hypertensive patients controlled their BP. Thus, health care providers need to be made aware about the importance of counseling hypertensive patients on drug adherence, moderate physical activity, and salt restriction to improve BP control.

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Section: Discussioncontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Blood pressure control status and associated factors among adult hypertensive patients on outpatient follow-up at University of Gondar Referral Hospital, northwest Ethiopia: a retrospective follow-up study

Animut¹,

Assefa²,

Lemma³

2018

IBPC

View full text Add to dashboard Cite

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“…14 Many studies in different parts of the world show that uncontrolled BP is a common phenomenon among hypertensive patients on treatment. [15][16][17][18] Thus, BP was controlled for only less than 50% of the hypertensive patients in Japan, 18 31.7% in Turkey, 19 and 48.3% in Malaysia. Controlling BP is a difficult experience in Africa too; BP control was accomplished for only 47.7% of the hypertensive patients on follow-up in Tanzania, 20 35.9% in Uganda, 21 32.8% in Zimbabwe, 22 33.4% in Kenya, 23 and 40.1% in Addis Ababa, Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated factors of hypertension complications among hypertensive patients at University of Gondar Comprehensive Specialized Referral Hospital

Kifle

Adugna

Chanie

et al. 2022

Clinical Epidemiology and Global Health

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Background: Cardiovascular diseases (CVDs) were non-communicable diseases that remain the leading cause of disability and death in the world. Therefore, this study aimed to assess the prevalence and associated factors of hypertension complications among hypertensive patients at University of Gondar comprehensive specialized referral hospital. Method: A cross-sectional study was conducted to assess the prevalence and associated factors of hypertension complications, from 1st June 2020 to 30th August 2020. Interview-guided self-administered questionnaire and a chart review were used for data collection. Statistical significance was set at a 95% confidence interval using a Pvalue of ≤0.05 as a cutoff point. Results: Out of 428 hypertensive patients, 261 (61.0%) were males. They were from 19 to 84 years age group and the mean age of participants was 53.55 ± 16.65 years. Participants with a family history of hypertension were 5 times more likely to develop complications than those with no family history of hypertension (AOR = 5.372, 95% CI = 2.378, 12.134, p = 0.001). Participants who had sedentary physical activity were 4 times more likely to develop complications than those who had vigorous physical activity (AOR = 4.049, 95% CI = 1.463, 11.206, p = 0.007). Participants who had high waist circumference were 7 times (AOR = 7.229, 95% CI = 1.436, 36.394, p = 0.016) more likely to develop complications than those who had low waist circumference. Conclusion: In this study, being female, illiterate participants, having a family history of hypertension, doing sedentary exercise and obesity are factors associated with hypertension complications.

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“…Hypertension is one of the major chronic diseases threatening human health, and it can cause myocardial infarction, renal failure, stroke and death if not detected early and treated properly; currently, more than 1 billion people worldwide suffer from hypertension . Clinically, the main drugs used for treating hypertension are the following: calcium channel blockers (CCBs), diuretics, antihypertensive drugs with central action, vasodilators, angiotensin‐converting enzyme inhibitors (ACEIs), β‐blockers, and angiotensin receptor blockers (ARBs) . In single drug therapy, CCBs are the most commonly used among these drugs because of their remarkable efficacy, extensive drug combination potential and protection of cardiac cerebral vessels .…”

Section: Introductionmentioning

confidence: 99%

Searching for calcium antagonists for hypertension disease therapy from Moutan Cortex, using bioactivity integrated UHPLC‐QTOF‐MS

Deng

Liu

et al. 2019

Phytochemical Analysis

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Introduction Calcium channel blockers (CCBs) are currently the most commonly used drugs for the treatment of hypertension. Moutan Cortex (MC), a traditional Chinese herb, has been found to have an anti‐hypertensive effect. However, its potential mechanisms in the regulation of intracellular calcium concentration ([Ca2+]i) remain poorly understood. Objective The main objective of this work was to identify the potential calcium antagonists from MC and study their molecular mechanisms. Methods Ultra‐high performance liquid chromatography‐quadrupole‐time‐of‐fight‐mass spectrometry (UHPLC‐QTOF‐MS) analysis combined with a dual‐luciferase reporter assay was utilised to systematically screen the calcium antagonistic active ingredients in the methanol extract of MC. Additionally, the molecular mechanism of these compounds was further studied using live‐cell imaging analysis with the calcium ion (Ca2+) probe dye fluo‐4/AM to monitor changes in [Ca2+]i. Results Three monoterpenoids (paeoniflorin, benzoylpaeoniflorin and mudanpioside C), one phenolic acid (paeonol) and one gallotannin (1,2,3,4,6‐O‐pentagalloylglucose) were screened out as potential calcium antagonists in MC. Among them, the calcium antagonistic activity of benzoylpaeoniflorin, mudanpioside C and 1,2,3,4,6‐O‐pentagalloylglucose is first reported. Additionally, paeoniflorin, benzoylpaeoniflorin, mudanpioside C and paeonol can effectively block voltage‐operated Ca2+ channels (VOCCs) to exert calcium antagonism, while 1,2,3,4,6‐O‐pentagalloylglucose plays a role in blocking inositol 1,4,5‐trisphosphate receptors (IP3Rs). Conclusion This work indicated that the anti‐hypertensive efficacy of MC acted through multiple components selectively antagonising multiple cell signalling pathways to regulate [Ca2+]i. Furthermore, they could be considered as a reference standard for controlling the quality of Chinese medicinal materials.

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HYT-Hypertension in Turkey: A Cross-Sectional Survey on Blood Pressure Control with Calcium Channel Blockers Alone or Combined with Other Antihypertensive Drugs

Cited by 8 publications

References 25 publications

Blood pressure control status and associated factors among adult hypertensive patients on outpatient follow-up at University of Gondar Referral Hospital, northwest Ethiopia: a retrospective follow-up study

Blood pressure control status and associated factors among adult hypertensive patients on outpatient follow-up at University of Gondar Referral Hospital, northwest Ethiopia: a retrospective follow-up study

Prevalence and associated factors of hypertension complications among hypertensive patients at University of Gondar Comprehensive Specialized Referral Hospital

Searching for calcium antagonists for hypertension disease therapy from Moutan Cortex, using bioactivity integrated UHPLC‐QTOF‐MS

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