Agaricus brasiliensismycelium supplementation in Sarcoma 180tumour-bearing mice reverses the immune response induced by the tumour

Abstract

The biological properties of Agaricus brasiliensis mycelium, including their immuno-stimulating and anti-tumour activities, have previously been investigated. The aim of this study was to evaluate the effects of long-term intake of A. brasiliensis mycelium cultivated on wheat grains by solid-state culture on tumour growth and immune response in Sarcoma 180 tumour-bearing mice. Mice received dietary supplementation with 100% or 50% Agaricus mycelium cultivated on wheat grains for 14 weeks and were inoculated with Sarcoma 180 tumours. We found that A. brasiliensis had anti-tumour activity, and that dietary supplementation with a 50% concentration (A50S) prevented loss of body weight, inhibited tumour growth, induced the increase of CD4 ' T cells and CD25 ' CD4 ' T subsets in peripheral organs and downregulated Tumor necrosis factor alpha production in plasma. Our results confirm that dietary supplementation with Agaricus may offer immunomodulatory activity and protection against tumour growth.

Dietary Polysaccharides and Immune Modulation

“…Some focus on simplifying and reducing the cost of production to provide access to a larger portion of the population or use in farm animals (Wasser 2011). Ingestion of myceliated wheat grains with G. lucidum and A. subrufescens or A. brasiliensis promote antitumor and hypocholesterolemic effects in sarcoma-180-bearing mice (Rubel et al 2008;Dalla-Santa et al 2012). Results of such trials led to the incorporation of many different myceliated grains, and later, using fruit and vegetable residues resulted in patents of processes and products.…”