<i>Aggregatibacter actinomycetemcomitans</i> in African Americans with Localized Aggressive Periodontitis

Burgess, Danielle K; Huang, Huei-Jean; Harrison, Peter; Aukhil, Ikramuddin; Shaddox, Luciana M.

doi:10.1177/2380084417695543

Cited by 25 publications

(47 citation statements)

References 31 publications

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“…The non‐JP2 sequence proved to be significantly less pronounced within this group, presenting in only 18.33% of both diseased and healthy sites. Coinfection with JP2 and non‐JP2 sequences was observed in 15% of diseased and healthy sites 22 . Among the 60 participants enrolled at baseline, 40 (66.67%) returned at 3 months for post‐treatment evaluation and 31 (51.67%) returned at both 6 and 12 months (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Sixty patients were included in this study. Baseline analysis of JP2 genotype prevalence within this group has been recently published 22 . An impressive 83% of this study population carried the JP2 genotype in either a diseased site (75%) or a healthy site (56.67%).…”

Section: Resultsmentioning

confidence: 99%

“…Bacterial DNA extraction and JP2 sequence detection proceeded, as previously described 22 . Briefly, bacterial DNA was isolated from subgingival plaque samples using a DNA purification kit, following the manufacturer's instructions # .…”

Section: Methodsmentioning

confidence: 99%

“…Power analysis for this study was determined by baseline differences between patients with LAgP and controls, as described previously 22 . Post hoc power analysis, run for the χ 2 test for the main outcome variable (presence of JP2 after treatment in diseased sites), showed a power of 89.6% for the lowest number of patients (31 at 12 months).…”

Section: Methodsmentioning

confidence: 99%

“…A recent study has reported cross‐sectional findings on prevalence of the JP2 and non‐JP2 sequences of Aa in a cohort of 60 African‐American children diagnosed with LAgP, of whom 83% (50) carried the JP2 genotype and 28.33% (17) carried the non‐JP2 genotype 22 . Understanding host and bacterial response to periodontal treatment and disease progression/resolution during maintenance is crucial for the development of improved treatment protocols.…”

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confidence: 99%

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Non‐Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis

Burgess

Huang

Harrison

et al. 2017

Journal of Periodontology

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Background Previous studies have provided substantial evidence on the association of Aggregatibacter actinomycetemcomitans (Aa), and its highly leukotoxic JP2 genotype, with localized aggressive periodontitis (LAP). The present study aims to evaluate the presence of JP2 in LAP individuals following periodontal treatment. Methods Sixty African American LAP patients between ages 5 and 25 years were examined. At baseline, pocket depth (PD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque index were measured and subgingival plaque was collected from both LAP diseased sites and healthy sites for each participant. Patients received whole-mouth ultrasonic debridement, scaling and root planning and a 7-day prescription of amoxicillin and metronidazole. Participants were re-evaluated, re-sampled and received regular maintenance therapy at 3, 6 and 12-months post-treatment. PCR technique was used detect presence of the JP2 genotype before and after treatment. Results At baseline, the JP2 sequence was identified in 75% of LAP diseased sites and in 56.67% of healthy sites. At 3, 6 and 12-months post-treatment, patient compliance was 40, 31 and 31, respectively, and JP2 detection decreased to 17.5%, 6.45% and 3.23% respectively, in diseased sites (P<0.001) and to 2.5%, 3.23% and 0% respectively, in healthy sites (P<0.001). Clinical parameters of disease were also significantly reduced after therapy (p<0001). Additionally, significant correlations were observed between JP2 presence and mean PD (p < 0.002) and CAL (p < 0.001), post-therapy. Conclusion Periodontal therapy was successful in reducing clinical parameters of LAP and the subgingival presence of JP2 in diseased and healthy sites.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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